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Link Between Oxidative Stress and Acute Brain Ischemia
(Angiology, 2014)
The pathogenesis of acute brain ischemia (ABI) is highly complex and involves multiple mechanisms including free radical generation. Imbalance between the cellular production of free radicals and the ability of cells to ...
Genotyping Fanconi Anemia Patients from Serbia Reveals Three Novel Fancd2 Variants
(Genetika, 2017)
Fanconi anemia is rare inherited disease characterized by wide spectrum of congenital anomalies, progressive pancytopenia, and predisposition to hematological malignancies and solid tumors. Molecular genetic analysis of ...
DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining
(RNA Biology, 2017)
Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical ...
Application of polymerase chain reaction (PCR) in virus diagnosis and bone marrow transplantation
(Jugoslovenska Medicinska Biohemija, 1996)
Polymerase chain reaction (PCR) is a very potent method enabling the amplification of target DNA sequences at least 10(5)-10(6) fold. The efficacy of PCR is measured by its specificity, efficiency (yield quantity) and ...
Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia
(Science Translational Medicine, 2021)
Chemoresistance remains the major challenge for successful treatment of acute myeloid leukemia (AML). Although recent mouse studies suggest that treatment response of genetically and immunophenotypically indistinguishable ...
Homocysteine and Hyperhomocysteinaemia
(Current Medicinal Chemistry, 2019)
Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical ...
PCSK9 and Hypercholesterolemia: Therapeutic Approach
(Current Drug Targets, 2018)
Despite the intensive research and progress in modern pharmacotherapy, hypercholesterolemia and related cardiovascular complications remain one of the leading causes of mortality and disability in the modern world. A ...
Cloning and expression profiling of muscle regulator ANKRD2 in domestic chicken Gallus gallus
(Histochemistry and Cell Biology, 2020)
Striated muscle signaling protein and transcriptional regulator ANKRD2 participates in myogenesis, myogenic differentiation, muscle adaptation and stress response. It is preferentially expressed in slow, oxidative fibers ...
Evaluation of antioxidant potential of Cordyceps sinensis in vitro / Evaluacija antioksidativnog potencijala gljive Cordyceps sinensis in vitro
(Medicinski časopis, 2019)
Objective. Prooxidants and antioxidants affect the oxidative balance at the intracellular level. Oxidative stress is a consequence of the overproduction of prooxidants and is caused by disturbances in the balance of oxidative ...
A simple PCR method for detection of defined point mutations
(Trends in Genetics, 1996)