TY  - JOUR
AU  - Prekodravac, Jovana
AU  - Vasiljević, Bojana R.
AU  - Žakula, Jelena
AU  - Popović, Maja
AU  - Pavlović, Vladimir
AU  - Ciasca, Gabriele
AU  - Romanò, Sabrina
AU  - Todorović Marković, Biljana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12446
AB  - Carbon quantum dots (CQDs) have exceptional physical-chemical properties that make them suitable for a wide range of uses, such as the photocatalytic removal of organic contaminants from water. Here, we provide a one-step, ecologically friendly, and economical method for creating iron/nitrogen co-doped (Fe/N-CQD) and nitrogen-doped (N-CQD) quantum dot nanomaterials. The characteristics of the developed nanomaterials were investigated with regard to how surface chemistry impacts their capacity for adsorption and photoactivity in a case study of a specific water pollutant reduction. The influence of the two irradiation sources-operating in the UV and visible ranges-on the photoactivity of materials was highlighted. Finally, their eco-friendliness was examined on four different human tumor cell lines.
T2  - Optical Materials
T1  - Carbon quantum dots surface chemistry: Evaluation of Photo and Cytotoxic activity
VL  - 147
SP  - 114629
DO  - 10.1016/j.optmat.2023.114629
ER  - 

@article{
author = "Prekodravac, Jovana and Vasiljević, Bojana R. and Žakula, Jelena and Popović, Maja and Pavlović, Vladimir and Ciasca, Gabriele and Romanò, Sabrina and Todorović Marković, Biljana",
year = "2024",
abstract = "Carbon quantum dots (CQDs) have exceptional physical-chemical properties that make them suitable for a wide range of uses, such as the photocatalytic removal of organic contaminants from water. Here, we provide a one-step, ecologically friendly, and economical method for creating iron/nitrogen co-doped (Fe/N-CQD) and nitrogen-doped (N-CQD) quantum dot nanomaterials. The characteristics of the developed nanomaterials were investigated with regard to how surface chemistry impacts their capacity for adsorption and photoactivity in a case study of a specific water pollutant reduction. The influence of the two irradiation sources-operating in the UV and visible ranges-on the photoactivity of materials was highlighted. Finally, their eco-friendliness was examined on four different human tumor cell lines.",
journal = "Optical Materials",
title = "Carbon quantum dots surface chemistry: Evaluation of Photo and Cytotoxic activity",
volume = "147",
pages = "114629",
doi = "10.1016/j.optmat.2023.114629"
}

Prekodravac, J., Vasiljević, B. R., Žakula, J., Popović, M., Pavlović, V., Ciasca, G., Romanò, S.,& Todorović Marković, B.. (2024). Carbon quantum dots surface chemistry: Evaluation of Photo and Cytotoxic activity. in Optical Materials, 147, 114629.
https://doi.org/10.1016/j.optmat.2023.114629

Prekodravac J, Vasiljević BR, Žakula J, Popović M, Pavlović V, Ciasca G, Romanò S, Todorović Marković B. Carbon quantum dots surface chemistry: Evaluation of Photo and Cytotoxic activity. in Optical Materials. 2024;147:114629.
doi:10.1016/j.optmat.2023.114629 .

Prekodravac, Jovana, Vasiljević, Bojana R., Žakula, Jelena, Popović, Maja, Pavlović, Vladimir, Ciasca, Gabriele, Romanò, Sabrina, Todorović Marković, Biljana, "Carbon quantum dots surface chemistry: Evaluation of Photo and Cytotoxic activity" in Optical Materials, 147 (2024):114629,
https://doi.org/10.1016/j.optmat.2023.114629 . .

TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Zdravković, Nemanja M.
AU  - Budimir Filimonović, Milica D.
AU  - Pavlović, Vladimir B.
AU  - Butulija, Svetlana
AU  - Milivojević, Dušan
AU  - Marković, Zoran M.
AU  - Todorović Marković, Biljana M.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12990
AB  - In this study, nanochitosan dots (ChiDs) were synthesized using gamma rays and encapsulated in bacterial cellulose (BC) polymer matrix for antibiofilm potential in photodynamic therapy. The composites were analyzed for structural changes using SEM, AFM, FTIR, XRD, EPR, and porosity measurements. Additionally, ChiD release was assessed. The results showed that the chemical composition remained unaltered, but ChiD agglomerates embedded in BC changed shape (1.5–2.5 µm). Bacterial cellulose fibers became deformed and interconnected, with increased surface roughness and porosity and decreased crystallinity. No singlet oxygen formation was observed, and the total amount of released ChiD was up to 16.10%. Antibiofilm activity was higher under green light, with reductions ranging from 48 to 57% under blue light and 78 to 85% under green light. Methicillin-resistant Staphylococcus aureus was the most sensitive strain. The new photoactive composite hydrogels show promising potential for combating biofilm-related infections.
T2  - Journal of Functional Biomaterials
T1  - Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light
VL  - 15
IS  - 3
SP  - 72
DO  - 10.3390/jfb15030072
ER  - 

@article{
author = "Zmejkoski, Danica and Zdravković, Nemanja M. and Budimir Filimonović, Milica D. and Pavlović, Vladimir B. and Butulija, Svetlana and Milivojević, Dušan and Marković, Zoran M. and Todorović Marković, Biljana M.",
year = "2024",
abstract = "In this study, nanochitosan dots (ChiDs) were synthesized using gamma rays and encapsulated in bacterial cellulose (BC) polymer matrix for antibiofilm potential in photodynamic therapy. The composites were analyzed for structural changes using SEM, AFM, FTIR, XRD, EPR, and porosity measurements. Additionally, ChiD release was assessed. The results showed that the chemical composition remained unaltered, but ChiD agglomerates embedded in BC changed shape (1.5–2.5 µm). Bacterial cellulose fibers became deformed and interconnected, with increased surface roughness and porosity and decreased crystallinity. No singlet oxygen formation was observed, and the total amount of released ChiD was up to 16.10%. Antibiofilm activity was higher under green light, with reductions ranging from 48 to 57% under blue light and 78 to 85% under green light. Methicillin-resistant Staphylococcus aureus was the most sensitive strain. The new photoactive composite hydrogels show promising potential for combating biofilm-related infections.",
journal = "Journal of Functional Biomaterials",
title = "Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light",
volume = "15",
number = "3",
pages = "72",
doi = "10.3390/jfb15030072"
}

Zmejkoski, D., Zdravković, N. M., Budimir Filimonović, M. D., Pavlović, V. B., Butulija, S., Milivojević, D., Marković, Z. M.,& Todorović Marković, B. M.. (2024). Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light. in Journal of Functional Biomaterials, 15(3), 72.
https://doi.org/10.3390/jfb15030072

Zmejkoski D, Zdravković NM, Budimir Filimonović MD, Pavlović VB, Butulija S, Milivojević D, Marković ZM, Todorović Marković BM. Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light. in Journal of Functional Biomaterials. 2024;15(3):72.
doi:10.3390/jfb15030072 .

Zmejkoski, Danica, Zdravković, Nemanja M., Budimir Filimonović, Milica D., Pavlović, Vladimir B., Butulija, Svetlana, Milivojević, Dušan, Marković, Zoran M., Todorović Marković, Biljana M., "Reduction in Pathogenic Biofilms by the Photoactive Composite of Bacterial Cellulose and Nanochitosan Dots under Blue and Green Light" in Journal of Functional Biomaterials, 15, no. 3 (2024):72,
https://doi.org/10.3390/jfb15030072 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Budimir Filimonović, Milica
AU  - Milivojević, Dušan
AU  - Kovač, Janez
AU  - Todorović-Marković, Biljana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12997
AB  - The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, and it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa). Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms.
T2  - Journal of Functional Biomaterials
T1  - Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films
VL  - 15
IS  - 3
SP  - 73
DO  - 10.3390/jfb15030073
ER  - 

@article{
author = "Marković, Zoran M. and Budimir Filimonović, Milica and Milivojević, Dušan and Kovač, Janez and Todorović-Marković, Biljana",
year = "2024",
abstract = "The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, and it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa). Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms.",
journal = "Journal of Functional Biomaterials",
title = "Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films",
volume = "15",
number = "3",
pages = "73",
doi = "10.3390/jfb15030073"
}

Marković, Z. M., Budimir Filimonović, M., Milivojević, D., Kovač, J.,& Todorović-Marković, B.. (2024). Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films. in Journal of Functional Biomaterials, 15(3), 73.
https://doi.org/10.3390/jfb15030073

Marković ZM, Budimir Filimonović M, Milivojević D, Kovač J, Todorović-Marković B. Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films. in Journal of Functional Biomaterials. 2024;15(3):73.
doi:10.3390/jfb15030073 .

Marković, Zoran M., Budimir Filimonović, Milica, Milivojević, Dušan, Kovač, Janez, Todorović-Marković, Biljana, "Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films" in Journal of Functional Biomaterials, 15, no. 3 (2024):73,
https://doi.org/10.3390/jfb15030073 . .

TY  - JOUR
AU  - Milenković, Mila
AU  - Ciasca, Gabriele
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12238
AB  - The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.
T2  - Journal of Photochemistry & Photobiology, B: Biology
T1  - Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects
VL  - 250
SP  - 112818
DO  - 10.1016/j.jphotobiol.2023.112818
ER  - 

@article{
author = "Milenković, Mila and Ciasca, Gabriele and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Todorović Marković, Biljana and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.",
journal = "Journal of Photochemistry & Photobiology, B: Biology",
title = "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects",
volume = "250",
pages = "112818",
doi = "10.1016/j.jphotobiol.2023.112818"
}

Milenković, M., Ciasca, G., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Todorović Marković, B.,& Jovanović, S.. (2024). Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology, 250, 112818.
https://doi.org/10.1016/j.jphotobiol.2023.112818

Milenković M, Ciasca G, Bonasera A, Scopelliti M, Marković O, Verbić T, Todorović Marković B, Jovanović S. Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology. 2024;250:112818.
doi:10.1016/j.jphotobiol.2023.112818 .

Milenković, Mila, Ciasca, Gabriele, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Todorović Marković, Biljana, Jovanović, Svetlana, "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects" in Journal of Photochemistry & Photobiology, B: Biology, 250 (2024):112818,
https://doi.org/10.1016/j.jphotobiol.2023.112818 . .

TY  - JOUR
AU  - Jovanović, Svetlana P.
AU  - Marković, Zoran M.
AU  - Budimir, Milica
AU  - Prekodravac, Jovana
AU  - Zmejkoski, Danica
AU  - Kepić, Dejan
AU  - Bonasera, Aurelio
AU  - Todorović-Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10926
AB  - The large number of deaths induced by carcinoma and infections indicates that the need for new, better, targeted therapy is higher than ever. Apart from classical treatments and medication, photodynamic therapy (PDT) is one of the possible approaches to cure these clinical conditions. This strategy offers several advantages, such as lower toxicity, selective treatment, faster recovery time, avoidance of systemic toxic effects, and others. Unfortunately, there is a small number of agents that are approved for usage in clinical PDT. Novel, efficient, biocompatible PDT agents are, thus, highly desired. One of the most promising candidates is represented by the broad family of carbon-based quantum dots, such as graphene quantum dots (GQDs), carbon quantum dots (CQDs), carbon nanodots (CNDs), and carbonized polymer dots (CPDs). In this review paper, these new smart nanomaterials are discussed as potential PDT agents, detailing their toxicity in the dark, and when they are exposed to light, as well as their effects on carcinoma and bacterial cells. The photoinduced effects of carbon-based quantum dots on bacteria and viruses are particularly interesting, since dots usually generate several highly toxic reactive oxygen species under blue light. These species are acting as bombs on pathogen cells, causing various devastating and toxic effects on those targets.
T2  - Pharmaceutics
T1  - Lights and Dots toward Therapy—Carbon-Based Quantum Dots as New Agents for Photodynamic Therapy
VL  - 15
IS  - 4
SP  - 1170
DO  - 10.3390/pharmaceutics15041170
ER  - 

@article{
author = "Jovanović, Svetlana P. and Marković, Zoran M. and Budimir, Milica and Prekodravac, Jovana and Zmejkoski, Danica and Kepić, Dejan and Bonasera, Aurelio and Todorović-Marković, Biljana",
year = "2023",
abstract = "The large number of deaths induced by carcinoma and infections indicates that the need for new, better, targeted therapy is higher than ever. Apart from classical treatments and medication, photodynamic therapy (PDT) is one of the possible approaches to cure these clinical conditions. This strategy offers several advantages, such as lower toxicity, selective treatment, faster recovery time, avoidance of systemic toxic effects, and others. Unfortunately, there is a small number of agents that are approved for usage in clinical PDT. Novel, efficient, biocompatible PDT agents are, thus, highly desired. One of the most promising candidates is represented by the broad family of carbon-based quantum dots, such as graphene quantum dots (GQDs), carbon quantum dots (CQDs), carbon nanodots (CNDs), and carbonized polymer dots (CPDs). In this review paper, these new smart nanomaterials are discussed as potential PDT agents, detailing their toxicity in the dark, and when they are exposed to light, as well as their effects on carcinoma and bacterial cells. The photoinduced effects of carbon-based quantum dots on bacteria and viruses are particularly interesting, since dots usually generate several highly toxic reactive oxygen species under blue light. These species are acting as bombs on pathogen cells, causing various devastating and toxic effects on those targets.",
journal = "Pharmaceutics",
title = "Lights and Dots toward Therapy—Carbon-Based Quantum Dots as New Agents for Photodynamic Therapy",
volume = "15",
number = "4",
pages = "1170",
doi = "10.3390/pharmaceutics15041170"
}

Jovanović, S. P., Marković, Z. M., Budimir, M., Prekodravac, J., Zmejkoski, D., Kepić, D., Bonasera, A.,& Todorović-Marković, B.. (2023). Lights and Dots toward Therapy—Carbon-Based Quantum Dots as New Agents for Photodynamic Therapy. in Pharmaceutics, 15(4), 1170.
https://doi.org/10.3390/pharmaceutics15041170

Jovanović SP, Marković ZM, Budimir M, Prekodravac J, Zmejkoski D, Kepić D, Bonasera A, Todorović-Marković B. Lights and Dots toward Therapy—Carbon-Based Quantum Dots as New Agents for Photodynamic Therapy. in Pharmaceutics. 2023;15(4):1170.
doi:10.3390/pharmaceutics15041170 .

Jovanović, Svetlana P., Marković, Zoran M., Budimir, Milica, Prekodravac, Jovana, Zmejkoski, Danica, Kepić, Dejan, Bonasera, Aurelio, Todorović-Marković, Biljana, "Lights and Dots toward Therapy—Carbon-Based Quantum Dots as New Agents for Photodynamic Therapy" in Pharmaceutics, 15, no. 4 (2023):1170,
https://doi.org/10.3390/pharmaceutics15041170 . .

TY  - JOUR
AU  - Kepić, Dejan P.
AU  - Stefanović, Anđela M.
AU  - Budimir, Milica
AU  - Pavlović, Vladimir B.
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Todorović-Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10426
AB  - Gamma irradiation provides an alternative pathway to conventional gold nanoparticle synthesis because it is simple, fast, and economical. Here, we employed gamma irradiation at low doses (1–20 kGy) to obtain gold nanoparticles (Au NPs) anchored onto graphene oxide (GO) sheets. GO was selected as a suitable platform for the nucleation and growth of Au NPs because of its large surface area and good dispersibility in water due to the presence of polar oxygen-containing functional groups in its structure. Gamma irradiation at all the applied doses led to the reduction of chloroauric acid and the formation of evenly distributed Au NPs at the GO surface, simultaneously causing the reduction of GO and partial restoration of the graphene structure. As-prepared Au NPs have predominately spheric shapes and the smallest nanoparticles were reported for the dose of 1 kGy. The increase in the irradiation dose caused either the growth of larger particles (5 and 10 kGy) or the broad distribution of particles’ sizes (20 kGy). All samples showed a temperature increase upon exposure to 800 nm laser and photothermal efficiency was the highest for the sample prepared at 20 kGy. © 2022 Elsevier Ltd
T2  - Radiation Physics and Chemistry
T1  - Gamma rays induced synthesis of graphene oxide/gold nanoparticle composites: structural and photothermal study
VL  - 202
DO  - 10.1016/j.radphyschem.2022.110545
ER  - 

@article{
author = "Kepić, Dejan P. and Stefanović, Anđela M. and Budimir, Milica and Pavlović, Vladimir B. and Bonasera, Aurelio and Scopelliti, Michelangelo and Todorović-Marković, Biljana",
year = "2023",
abstract = "Gamma irradiation provides an alternative pathway to conventional gold nanoparticle synthesis because it is simple, fast, and economical. Here, we employed gamma irradiation at low doses (1–20 kGy) to obtain gold nanoparticles (Au NPs) anchored onto graphene oxide (GO) sheets. GO was selected as a suitable platform for the nucleation and growth of Au NPs because of its large surface area and good dispersibility in water due to the presence of polar oxygen-containing functional groups in its structure. Gamma irradiation at all the applied doses led to the reduction of chloroauric acid and the formation of evenly distributed Au NPs at the GO surface, simultaneously causing the reduction of GO and partial restoration of the graphene structure. As-prepared Au NPs have predominately spheric shapes and the smallest nanoparticles were reported for the dose of 1 kGy. The increase in the irradiation dose caused either the growth of larger particles (5 and 10 kGy) or the broad distribution of particles’ sizes (20 kGy). All samples showed a temperature increase upon exposure to 800 nm laser and photothermal efficiency was the highest for the sample prepared at 20 kGy. © 2022 Elsevier Ltd",
journal = "Radiation Physics and Chemistry",
title = "Gamma rays induced synthesis of graphene oxide/gold nanoparticle composites: structural and photothermal study",
volume = "202",
doi = "10.1016/j.radphyschem.2022.110545"
}

Kepić, D. P., Stefanović, A. M., Budimir, M., Pavlović, V. B., Bonasera, A., Scopelliti, M.,& Todorović-Marković, B.. (2023). Gamma rays induced synthesis of graphene oxide/gold nanoparticle composites: structural and photothermal study. in Radiation Physics and Chemistry, 202.
https://doi.org/10.1016/j.radphyschem.2022.110545

Kepić DP, Stefanović AM, Budimir M, Pavlović VB, Bonasera A, Scopelliti M, Todorović-Marković B. Gamma rays induced synthesis of graphene oxide/gold nanoparticle composites: structural and photothermal study. in Radiation Physics and Chemistry. 2023;202.
doi:10.1016/j.radphyschem.2022.110545 .

Kepić, Dejan P., Stefanović, Anđela M., Budimir, Milica, Pavlović, Vladimir B., Bonasera, Aurelio, Scopelliti, Michelangelo, Todorović-Marković, Biljana, "Gamma rays induced synthesis of graphene oxide/gold nanoparticle composites: structural and photothermal study" in Radiation Physics and Chemistry, 202 (2023),
https://doi.org/10.1016/j.radphyschem.2022.110545 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Budimir, Milica
AU  - Danko, Martin
AU  - Milivojević, Dušan
AU  - Kubat, Pavel
AU  - Zmejkoski, Danica
AU  - Pavlović, Vladimir B.
AU  - Mojsin, Marija
AU  - Stevanović, Milena J.
AU  - Todorović-Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10632
AB  - Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as probes for bioimaging.
T2  - Beilstein Journal of Nanotechnology
T1  - Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine
VL  - 14
IS  - 1
SP  - 165
EP  - 174
DO  - 10.3762/bjnano.14.17
ER  - 

@article{
author = "Marković, Zoran M. and Budimir, Milica and Danko, Martin and Milivojević, Dušan and Kubat, Pavel and Zmejkoski, Danica and Pavlović, Vladimir B. and Mojsin, Marija and Stevanović, Milena J. and Todorović-Marković, Biljana",
year = "2023",
abstract = "Carbon quantum dots as a novel type of carbon nanomaterials have attracted the attention of many researchers because of their unique optical, antibacterial, and anticancer properties as well as their biocompatibility. In this study, for the first time, carbon quantum dots were prepared from o-phenylenediamine dissolved in toluene by a solvothermal route. Subsequently, the prepared carbon quantum dots were encapsulated into polyurethane films by a swelling–encapsulation–shrink method. Analyses of the results obtained by different characterization methods (AFM, TEM, EDS, FTIR, photoluminescence, and EPR) indicate the significant influence of the precursor on structural, chemical, and optical properties. Antibacterial and cytotoxicity tests showed that these dots did not have any antibacterial potential, because of the low extent of reactive oxygen species production, and showed low dark cytotoxicity. By investigating the cellular uptake, it was established that these dots penetrated the HeLa cells and could be used as probes for bioimaging.",
journal = "Beilstein Journal of Nanotechnology",
title = "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine",
volume = "14",
number = "1",
pages = "165-174",
doi = "10.3762/bjnano.14.17"
}

Marković, Z. M., Budimir, M., Danko, M., Milivojević, D., Kubat, P., Zmejkoski, D., Pavlović, V. B., Mojsin, M., Stevanović, M. J.,& Todorović-Marković, B.. (2023). Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology, 14(1), 165-174.
https://doi.org/10.3762/bjnano.14.17

Marković ZM, Budimir M, Danko M, Milivojević D, Kubat P, Zmejkoski D, Pavlović VB, Mojsin M, Stevanović MJ, Todorović-Marković B. Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine. in Beilstein Journal of Nanotechnology. 2023;14(1):165-174.
doi:10.3762/bjnano.14.17 .

Marković, Zoran M., Budimir, Milica, Danko, Martin, Milivojević, Dušan, Kubat, Pavel, Zmejkoski, Danica, Pavlović, Vladimir B., Mojsin, Marija, Stevanović, Milena J., Todorović-Marković, Biljana, "Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine" in Beilstein Journal of Nanotechnology, 14, no. 1 (2023):165-174,
https://doi.org/10.3762/bjnano.14.17 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Mišović, Aleksandra
AU  - Zmejkoski, Danica
AU  - Zdravković, Nemanja M.
AU  - Kovač, Janez
AU  - Bajuk-Bogdanović, Danica
AU  - Milivojević, Dušan
AU  - Mojsin, Marija
AU  - Stevanović, Milena
AU  - Pavlović, Vladimir B.
AU  - Todorović-Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11075
AB  - Nowadays, it is a great challenge to develop new medicines for treating various infectious diseases. The treatment of these diseases is of utmost interest to further prevent the development of multi-drug resistance in different pathogens. Carbon quantum dots, as a new member of the carbon nanomaterials family, can potentially be used as a highly promising visible-light-triggered antibacterial agent. In this work, the results of antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots are presented. Carbon quantum dots (CQDs) were synthesized from citric acid by a pyrolysis procedure and irradiated by gamma rays at different doses (25, 50, 100 and 200 kGy). Structure, chemical composition and optical properties were investigated by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Vis spectrometry and photoluminescence. Structural analysis showed that CQDs have a spherical-like shape and dose-dependent average diameters and heights. Antibacterial tests showed that all irradiated dots had antibacterial activity but CQDs irradiated with dose of 100 kGy had antibacterial activity against all seven pathogen-reference bacterial strains. Gamma-ray-modified CQDs did not show any cytotoxicity toward human fetal-originated MRC-5 cells. Moreover, fluorescence microscopy showed excellent cellular uptake of CQDs irradiated with doses of 25 and 200 kGy into MRC-5 cells.
T2  - Antibiotics
T1  - Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria
VL  - 12
IS  - 5
SP  - 919
DO  - 10.3390/antibiotics12050919
ER  - 

@article{
author = "Marković, Zoran M. and Mišović, Aleksandra and Zmejkoski, Danica and Zdravković, Nemanja M. and Kovač, Janez and Bajuk-Bogdanović, Danica and Milivojević, Dušan and Mojsin, Marija and Stevanović, Milena and Pavlović, Vladimir B. and Todorović-Marković, Biljana",
year = "2023",
abstract = "Nowadays, it is a great challenge to develop new medicines for treating various infectious diseases. The treatment of these diseases is of utmost interest to further prevent the development of multi-drug resistance in different pathogens. Carbon quantum dots, as a new member of the carbon nanomaterials family, can potentially be used as a highly promising visible-light-triggered antibacterial agent. In this work, the results of antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots are presented. Carbon quantum dots (CQDs) were synthesized from citric acid by a pyrolysis procedure and irradiated by gamma rays at different doses (25, 50, 100 and 200 kGy). Structure, chemical composition and optical properties were investigated by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Vis spectrometry and photoluminescence. Structural analysis showed that CQDs have a spherical-like shape and dose-dependent average diameters and heights. Antibacterial tests showed that all irradiated dots had antibacterial activity but CQDs irradiated with dose of 100 kGy had antibacterial activity against all seven pathogen-reference bacterial strains. Gamma-ray-modified CQDs did not show any cytotoxicity toward human fetal-originated MRC-5 cells. Moreover, fluorescence microscopy showed excellent cellular uptake of CQDs irradiated with doses of 25 and 200 kGy into MRC-5 cells.",
journal = "Antibiotics",
title = "Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria",
volume = "12",
number = "5",
pages = "919",
doi = "10.3390/antibiotics12050919"
}

Marković, Z. M., Mišović, A., Zmejkoski, D., Zdravković, N. M., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V. B.,& Todorović-Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919.
https://doi.org/10.3390/antibiotics12050919

Marković ZM, Mišović A, Zmejkoski D, Zdravković NM, Kovač J, Bajuk-Bogdanović D, Milivojević D, Mojsin M, Stevanović M, Pavlović VB, Todorović-Marković B. Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics. 2023;12(5):919.
doi:10.3390/antibiotics12050919 .

Marković, Zoran M., Mišović, Aleksandra, Zmejkoski, Danica, Zdravković, Nemanja M., Kovač, Janez, Bajuk-Bogdanović, Danica, Milivojević, Dušan, Mojsin, Marija, Stevanović, Milena, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria" in Antibiotics, 12, no. 5 (2023):919,
https://doi.org/10.3390/antibiotics12050919 . .

TY  - CONF
AU  - Stefanović, Anđela
AU  - Kepić, Dejan
AU  - Jovanović Vučetić, Svetlana
AU  - Haddadi, Kamel
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12320
AB  - Silver nitrate has been exposed to low-dose (1–20 kGy) gamma irradiation in the presence of graphene-based material (graphene oxide or electrochemically exfoliated graphene) to form silver nanoparticles (Ag NPs). The successful nucleation and growth of Ag NPs, which produce the evenly covered graphene surface, are made possible by the vast surface area of those graphene-based materials as well as the presence of oxygen-containing functional groups on the surface. With a significant size distribution of 10–50 nm for graphene oxide and 10–100 nm for electrochemically exfoliated graphene, the produced Ag NPs were spherical. We also performed ElectroMagnetic Interference (EMI) shielding performance measurements of these materials. EMI shielding performance measurement revealed relatively good performance of the EEG material whereas GO material does not show EM shielding.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
T1  - Measurement of EMI shielding perfomance of graphene oxide – silver nanoparticles composites
SP  - 47
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12320
ER  - 

@conference{
author = "Stefanović, Anđela and Kepić, Dejan and Jovanović Vučetić, Svetlana and Haddadi, Kamel and Todorović Marković, Biljana",
year = "2023",
abstract = "Silver nitrate has been exposed to low-dose (1–20 kGy) gamma irradiation in the presence of graphene-based material (graphene oxide or electrochemically exfoliated graphene) to form silver nanoparticles (Ag NPs). The successful nucleation and growth of Ag NPs, which produce the evenly covered graphene surface, are made possible by the vast surface area of those graphene-based materials as well as the presence of oxygen-containing functional groups on the surface. With a significant size distribution of 10–50 nm for graphene oxide and 10–100 nm for electrochemically exfoliated graphene, the produced Ag NPs were spherical. We also performed ElectroMagnetic Interference (EMI) shielding performance measurements of these materials. EMI shielding performance measurement revealed relatively good performance of the EEG material whereas GO material does not show EM shielding.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts",
title = "Measurement of EMI shielding perfomance of graphene oxide – silver nanoparticles composites",
pages = "47-47",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12320"
}

Stefanović, A., Kepić, D., Jovanović Vučetić, S., Haddadi, K.,& Todorović Marković, B.. (2023). Measurement of EMI shielding perfomance of graphene oxide – silver nanoparticles composites. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
Belgrade : Institute of Technical Sciences of SASA., 47-47.
https://hdl.handle.net/21.15107/rcub_vinar_12320

Stefanović A, Kepić D, Jovanović Vučetić S, Haddadi K, Todorović Marković B. Measurement of EMI shielding perfomance of graphene oxide – silver nanoparticles composites. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:47-47.
https://hdl.handle.net/21.15107/rcub_vinar_12320 .

Stefanović, Anđela, Kepić, Dejan, Jovanović Vučetić, Svetlana, Haddadi, Kamel, Todorović Marković, Biljana, "Measurement of EMI shielding perfomance of graphene oxide – silver nanoparticles composites" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):47-47,
https://hdl.handle.net/21.15107/rcub_vinar_12320 .

TY  - CONF
AU  - Dorontić, Slađana
AU  - Jovanović, Svetlana
AU  - Jovanović Vučetić, Svetlana
AU  - Todorović Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12321
AB  - Due to the exponential growth of bacterial infection as well as resistance toward most antibiotics, the development of new materials for treatment is urgently needed. In recent years, graphene quantum dots (GQDs) have been identified as promising carbon nanomaterial for eco-friendly antibacterial applications due to their optical and chemical stability, non-toxicity, and biocompatibility. One of the reported GQD’s antimicrobial mechanisms is the photo-induced production of singlet oxygen (1O2). Under light exposure, GQDs transfer the energy to molecular oxygen from the surrounding medium. Oxygen molecules transform to their excited form 1O2, which causes oxidative stress in bacterial cells and reduces their viability. In this study, pristine GQDs were produced in an easy, one-step electrochemical top-down approach using graphite electrodes as a starting material. Carboxyl groups of GQDs are modified using a carbodiimide coupling reaction catalyzed by 1-ethyl-3- (3-dimethylaminopropyl)carbodiimide (EDC), with ethylenediamine (EDA) as an amine. In the next step, these NH2 terminated dots were decorated with gold nanoparticles (AuNPs) by the same EDC coupling procedure. Abillity of GQDs-AuNP nanocomposite to generate singlet oxygen upon blue light (470 nm) was investigated by UV-Vis spectroscopy and 9,10- anthracenediylbis-(methylene)dimalonic acid (ABDA) as selective 1O2 traping agent. After 2 hours of blue light illumination, the band at 420 nm charachterisic for ABDA was completly disaperided only in the presence of the GQD-AuNPs indicating good prooxidative potential of composite. Photoinduced antibacterial effects of GQD-AuNPs were studied using minimum inhibitory concentration (MIC) test which showed great antibacterial activity against several bacterial strains.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
T1  - Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots
SP  - 48
EP  - 48
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12321
ER  - 

@conference{
author = "Dorontić, Slađana and Jovanović, Svetlana and Jovanović Vučetić, Svetlana and Todorović Marković, Biljana",
year = "2023",
abstract = "Due to the exponential growth of bacterial infection as well as resistance toward most antibiotics, the development of new materials for treatment is urgently needed. In recent years, graphene quantum dots (GQDs) have been identified as promising carbon nanomaterial for eco-friendly antibacterial applications due to their optical and chemical stability, non-toxicity, and biocompatibility. One of the reported GQD’s antimicrobial mechanisms is the photo-induced production of singlet oxygen (1O2). Under light exposure, GQDs transfer the energy to molecular oxygen from the surrounding medium. Oxygen molecules transform to their excited form 1O2, which causes oxidative stress in bacterial cells and reduces their viability. In this study, pristine GQDs were produced in an easy, one-step electrochemical top-down approach using graphite electrodes as a starting material. Carboxyl groups of GQDs are modified using a carbodiimide coupling reaction catalyzed by 1-ethyl-3- (3-dimethylaminopropyl)carbodiimide (EDC), with ethylenediamine (EDA) as an amine. In the next step, these NH2 terminated dots were decorated with gold nanoparticles (AuNPs) by the same EDC coupling procedure. Abillity of GQDs-AuNP nanocomposite to generate singlet oxygen upon blue light (470 nm) was investigated by UV-Vis spectroscopy and 9,10- anthracenediylbis-(methylene)dimalonic acid (ABDA) as selective 1O2 traping agent. After 2 hours of blue light illumination, the band at 420 nm charachterisic for ABDA was completly disaperided only in the presence of the GQD-AuNPs indicating good prooxidative potential of composite. Photoinduced antibacterial effects of GQD-AuNPs were studied using minimum inhibitory concentration (MIC) test which showed great antibacterial activity against several bacterial strains.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts",
title = "Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots",
pages = "48-48",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12321"
}

Dorontić, S., Jovanović, S., Jovanović Vučetić, S.,& Todorović Marković, B.. (2023). Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
Belgrade : Institute of Technical Sciences of SASA., 48-48.
https://hdl.handle.net/21.15107/rcub_vinar_12321

Dorontić S, Jovanović S, Jovanović Vučetić S, Todorović Marković B. Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:48-48.
https://hdl.handle.net/21.15107/rcub_vinar_12321 .

Dorontić, Slađana, Jovanović, Svetlana, Jovanović Vučetić, Svetlana, Todorović Marković, Biljana, "Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):48-48,
https://hdl.handle.net/21.15107/rcub_vinar_12321 .

TY  - CONF
AU  - Milenković, Mila
AU  - Dorontić, Slađana
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12322
AB  - Considering the rising concern of antibiotic resistance, developing advanced antibacterial solutions is highly needed. The ability of graphene quantum dots (GQDs) to generate reactive oxygen species (ROS) upon light exposure made them promising candidates as agents in photodynamic therapy for combatting infections, including antibiotic-resistant strains. GQDs show versatile chemical, physical, and biological properties such as high fluorescent activity, resistance to photo-bleaching, low toxicity, excellent solubility, and biocompatibility. This research focused on exploring the ability of GQDs to produce singlet oxygen under blue light exposure. We used two singlet oxygen probes, 9,10-anthracenediylbis(methylene) dimalonic acid and 1,3-diphenylisobenzofuran to study photoinduced production radicals from several GQDs. To tune the ability of GQDs to generate ROS, we used gamma irradiation in two different media, the presence of L-cysteine and cyclopentanone. The results showed improvements in singlet oxygen production in both cases. However, the modification conducted with cyclopentanol showed notably higher efficacy in promoting singlet oxygen production. This research demonstrates the increasing significance of GQDs in discovering new methods to combat bacteria. The modification of GQDs with gamma irradiation leads to increased production of singlet oxygen enhancing the effectiveness of photodynamic therapy for treating infections.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
T1  - Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment
SP  - 49
EP  - 49
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12322
ER  - 

@conference{
author = "Milenković, Mila and Dorontić, Slađana and Todorović Marković, Biljana and Jovanović, Svetlana",
year = "2023",
abstract = "Considering the rising concern of antibiotic resistance, developing advanced antibacterial solutions is highly needed. The ability of graphene quantum dots (GQDs) to generate reactive oxygen species (ROS) upon light exposure made them promising candidates as agents in photodynamic therapy for combatting infections, including antibiotic-resistant strains. GQDs show versatile chemical, physical, and biological properties such as high fluorescent activity, resistance to photo-bleaching, low toxicity, excellent solubility, and biocompatibility. This research focused on exploring the ability of GQDs to produce singlet oxygen under blue light exposure. We used two singlet oxygen probes, 9,10-anthracenediylbis(methylene) dimalonic acid and 1,3-diphenylisobenzofuran to study photoinduced production radicals from several GQDs. To tune the ability of GQDs to generate ROS, we used gamma irradiation in two different media, the presence of L-cysteine and cyclopentanone. The results showed improvements in singlet oxygen production in both cases. However, the modification conducted with cyclopentanol showed notably higher efficacy in promoting singlet oxygen production. This research demonstrates the increasing significance of GQDs in discovering new methods to combat bacteria. The modification of GQDs with gamma irradiation leads to increased production of singlet oxygen enhancing the effectiveness of photodynamic therapy for treating infections.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts",
title = "Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment",
pages = "49-49",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12322"
}

Milenković, M., Dorontić, S., Todorović Marković, B.,& Jovanović, S.. (2023). Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
Belgrade : Institute of Technical Sciences of SASA., 49-49.
https://hdl.handle.net/21.15107/rcub_vinar_12322

Milenković M, Dorontić S, Todorović Marković B, Jovanović S. Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:49-49.
https://hdl.handle.net/21.15107/rcub_vinar_12322 .

Milenković, Mila, Dorontić, Slađana, Todorović Marković, Biljana, Jovanović, Svetlana, "Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):49-49,
https://hdl.handle.net/21.15107/rcub_vinar_12322 .

TY  - CONF
AU  - Dorontić, Slađana
AU  - Milivojević, Dušan
AU  - Jovanović, Svetlana P.
AU  - Todorović-Marković, Biljana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12504
PB  - Belgrade : Serbian Chemical Society
C3  - 9th Symposium Chemistry and Environmental Protection : Book of Abstracts
T1  - Photo-induced prooxidative and antioxidative properties of gamma-irradiated graphene quantum dots
SP  - 145
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12504
ER  - 

@conference{
author = "Dorontić, Slađana and Milivojević, Dušan and Jovanović, Svetlana P. and Todorović-Marković, Biljana",
year = "2023",
publisher = "Belgrade : Serbian Chemical Society",
journal = "9th Symposium Chemistry and Environmental Protection : Book of Abstracts",
title = "Photo-induced prooxidative and antioxidative properties of gamma-irradiated graphene quantum dots",
pages = "145-146",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12504"
}

Dorontić, S., Milivojević, D., Jovanović, S. P.,& Todorović-Marković, B.. (2023). Photo-induced prooxidative and antioxidative properties of gamma-irradiated graphene quantum dots. in 9th Symposium Chemistry and Environmental Protection : Book of Abstracts
Belgrade : Serbian Chemical Society., 145-146.
https://hdl.handle.net/21.15107/rcub_vinar_12504

Dorontić S, Milivojević D, Jovanović SP, Todorović-Marković B. Photo-induced prooxidative and antioxidative properties of gamma-irradiated graphene quantum dots. in 9th Symposium Chemistry and Environmental Protection : Book of Abstracts. 2023;:145-146.
https://hdl.handle.net/21.15107/rcub_vinar_12504 .

Dorontić, Slađana, Milivojević, Dušan, Jovanović, Svetlana P., Todorović-Marković, Biljana, "Photo-induced prooxidative and antioxidative properties of gamma-irradiated graphene quantum dots" in 9th Symposium Chemistry and Environmental Protection : Book of Abstracts (2023):145-146,
https://hdl.handle.net/21.15107/rcub_vinar_12504 .

TY  - JOUR
AU  - Prekodravac, Jovana
AU  - Budimir, Milica
AU  - Kleut, Duška
AU  - Vasiljević, Bojana R.
AU  - Rajić, Vladimir
AU  - Ciasca, Gabriele
AU  - Todorović-Marković, Biljana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10441
AB  - The carbon quantum dots (CQDs) as zero-dimensional carbon nanomaterials with extraordinary physicochemical properties have a broad range of applications. Some of the most intriguing is the CQD thin films for electronic devices and membrane nanofiltration. Here we present the simple and affordable microwave-assisted synthesis method for the production of the nitrogen-doped CQDs (N-CQD) and iron/nitrogen co-doped CQDs (FeN-CQD). The comprehensive study of the morphology and electrical properties of N-CQD and FeN-CQD was discussed after manufacturing obtained nanomaterials in the form of a thin film on different substrates using different deposition procedures. The morphological features of generated thin films altered dramatically when the substrate and nanomaterial properties, as well as the number of deposited layers of CQDs and the chosen deposition process, were taken into consideration.
T2  - Diamond and Related Materials
T1  - Surface functionality as a key parameter for the conductivity of microwave synthesized CQDs thin films
VL  - 129
SP  - 109366
DO  - 10.1016/j.diamond.2022.109366
ER  - 

@article{
author = "Prekodravac, Jovana and Budimir, Milica and Kleut, Duška and Vasiljević, Bojana R. and Rajić, Vladimir and Ciasca, Gabriele and Todorović-Marković, Biljana",
year = "2022",
abstract = "The carbon quantum dots (CQDs) as zero-dimensional carbon nanomaterials with extraordinary physicochemical properties have a broad range of applications. Some of the most intriguing is the CQD thin films for electronic devices and membrane nanofiltration. Here we present the simple and affordable microwave-assisted synthesis method for the production of the nitrogen-doped CQDs (N-CQD) and iron/nitrogen co-doped CQDs (FeN-CQD). The comprehensive study of the morphology and electrical properties of N-CQD and FeN-CQD was discussed after manufacturing obtained nanomaterials in the form of a thin film on different substrates using different deposition procedures. The morphological features of generated thin films altered dramatically when the substrate and nanomaterial properties, as well as the number of deposited layers of CQDs and the chosen deposition process, were taken into consideration.",
journal = "Diamond and Related Materials",
title = "Surface functionality as a key parameter for the conductivity of microwave synthesized CQDs thin films",
volume = "129",
pages = "109366",
doi = "10.1016/j.diamond.2022.109366"
}

Prekodravac, J., Budimir, M., Kleut, D., Vasiljević, B. R., Rajić, V., Ciasca, G.,& Todorović-Marković, B.. (2022). Surface functionality as a key parameter for the conductivity of microwave synthesized CQDs thin films. in Diamond and Related Materials, 129, 109366.
https://doi.org/10.1016/j.diamond.2022.109366

Prekodravac J, Budimir M, Kleut D, Vasiljević BR, Rajić V, Ciasca G, Todorović-Marković B. Surface functionality as a key parameter for the conductivity of microwave synthesized CQDs thin films. in Diamond and Related Materials. 2022;129:109366.
doi:10.1016/j.diamond.2022.109366 .

Prekodravac, Jovana, Budimir, Milica, Kleut, Duška, Vasiljević, Bojana R., Rajić, Vladimir, Ciasca, Gabriele, Todorović-Marković, Biljana, "Surface functionality as a key parameter for the conductivity of microwave synthesized CQDs thin films" in Diamond and Related Materials, 129 (2022):109366,
https://doi.org/10.1016/j.diamond.2022.109366 . .

TY  - JOUR
AU  - Dorontić, Slađana
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Bajuk Bogdanović, Danica
AU  - Ciasca, Gabriele
AU  - Romanò, Sabrina
AU  - Dimkić, Ivica
AU  - Budimir, Milica
AU  - Marinković, Dragana
AU  - Jovanović, Svetlana P.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10406
AB  - Structural modification of different carbon-based nanomaterials is often necessary toimprove their morphology and optical properties, particularly the incorporation of N-atoms ingraphene quantum dots (GQDs). Here, a clean, simple, one-step, and eco-friendly method forN-doping of GQDs using gamma irradiation is reported. GQDs were irradiated in the presenceof the different ethylenediamine (EDA) amounts (1 g, 5 g, and 10 g) and the highest % of N wasdetected in the presence of 10 g. N-doped GQDs emitted strong, blue photoluminescence (PL).Photoluminescence quantum yield was increased from 1.45, as obtained for non-irradiated dots,to 7.24% for those irradiated in the presence of 1 g of EDA. Modified GQDs were investigated asa PL probe for the detection of insecticide Carbofuran (2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate) and herbicide Amitrole (3-amino-1,2,4-triazole). The limit of detection was5.4 µmol L−1for Carbofuran. For the first time, Amitrole was detected by GQDs in a turn-off/turn-onmechanism using Pd(II) ions as a quenching agent. First, Pd(II) ions were quenched (turn-off) PLof GQDs, while after Amitrole addition, PL was recovered linearly with Amitrole concentration(turn-on). LOD was 2.03 µmol L−1. These results suggest that modified GQDs can be used as anefficient new material for Carbofuran and Amitrole detection. Furthermore, the phototoxicity of dotswas investigated on both Gram-positive and Gram-negative bacterial strains. When bacterial cellswere exposed to different GQD concentrations and illuminated with light of 470 nm wavelength, thetoxic effects were not observed.
T2  - Nanomaterials
T1  - Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains
VL  - 12
SP  - 2714
DO  - 10.3390/nano12152714
ER  - 

@article{
author = "Dorontić, Slađana and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Bajuk Bogdanović, Danica and Ciasca, Gabriele and Romanò, Sabrina and Dimkić, Ivica and Budimir, Milica and Marinković, Dragana and Jovanović, Svetlana P.",
year = "2022",
abstract = "Structural modification of different carbon-based nanomaterials is often necessary toimprove their morphology and optical properties, particularly the incorporation of N-atoms ingraphene quantum dots (GQDs). Here, a clean, simple, one-step, and eco-friendly method forN-doping of GQDs using gamma irradiation is reported. GQDs were irradiated in the presenceof the different ethylenediamine (EDA) amounts (1 g, 5 g, and 10 g) and the highest % of N wasdetected in the presence of 10 g. N-doped GQDs emitted strong, blue photoluminescence (PL).Photoluminescence quantum yield was increased from 1.45, as obtained for non-irradiated dots,to 7.24% for those irradiated in the presence of 1 g of EDA. Modified GQDs were investigated asa PL probe for the detection of insecticide Carbofuran (2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate) and herbicide Amitrole (3-amino-1,2,4-triazole). The limit of detection was5.4 µmol L−1for Carbofuran. For the first time, Amitrole was detected by GQDs in a turn-off/turn-onmechanism using Pd(II) ions as a quenching agent. First, Pd(II) ions were quenched (turn-off) PLof GQDs, while after Amitrole addition, PL was recovered linearly with Amitrole concentration(turn-on). LOD was 2.03 µmol L−1. These results suggest that modified GQDs can be used as anefficient new material for Carbofuran and Amitrole detection. Furthermore, the phototoxicity of dotswas investigated on both Gram-positive and Gram-negative bacterial strains. When bacterial cellswere exposed to different GQD concentrations and illuminated with light of 470 nm wavelength, thetoxic effects were not observed.",
journal = "Nanomaterials",
title = "Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains",
volume = "12",
pages = "2714",
doi = "10.3390/nano12152714"
}

Dorontić, S., Bonasera, A., Scopelliti, M., Marković, O., Bajuk Bogdanović, D., Ciasca, G., Romanò, S., Dimkić, I., Budimir, M., Marinković, D.,& Jovanović, S. P.. (2022). Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains. in Nanomaterials, 12, 2714.
https://doi.org/10.3390/nano12152714

Dorontić S, Bonasera A, Scopelliti M, Marković O, Bajuk Bogdanović D, Ciasca G, Romanò S, Dimkić I, Budimir M, Marinković D, Jovanović SP. Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains. in Nanomaterials. 2022;12:2714.
doi:10.3390/nano12152714 .

Dorontić, Slađana, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Bajuk Bogdanović, Danica, Ciasca, Gabriele, Romanò, Sabrina, Dimkić, Ivica, Budimir, Milica, Marinković, Dragana, Jovanović, Svetlana P., "Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains" in Nanomaterials, 12 (2022):2714,
https://doi.org/10.3390/nano12152714 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kováčová, Mária
AU  - Jeremić, Sanja
AU  - Nagy, Štefan
AU  - Milivojević, Dušan
AU  - Kubat, Pavel
AU  - Kleinová, Angela
AU  - Budimir, Milica
AU  - Mojsin, Marija
AU  - Stevanović, Milena J.
AU  - Annušová, Adriana
AU  - Špitalský, Zdeno
AU  - Todorović-Marković, Biljana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10517
AB  - Development of new types of antimicrobial coatings is of utmost importance due to increasing problems with pathogen transmission from various infectious surfaces to human beings. In this study, new types of highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots are presented. Detailed structural, optical, antimicrobial, and cytotoxic investigations of these composites were conducted. Low-power blue light triggered the composites to eradicate Escherichia coli in 30 min, whereas the same effect toward Staphylococcus aureus was reached after 60 min. These composites also show low toxicity against MRC-5 cells. In this way, RF-CPD composites can be used for sterilization of highly touched objects in the healthcare industry.
T2  - Nanomaterials
T1  - Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots
VL  - 12
IS  - 22
SP  - 4070
DO  - 10.3390/nano12224070
ER  - 

@article{
author = "Marković, Zoran M. and Kováčová, Mária and Jeremić, Sanja and Nagy, Štefan and Milivojević, Dušan and Kubat, Pavel and Kleinová, Angela and Budimir, Milica and Mojsin, Marija and Stevanović, Milena J. and Annušová, Adriana and Špitalský, Zdeno and Todorović-Marković, Biljana",
year = "2022",
abstract = "Development of new types of antimicrobial coatings is of utmost importance due to increasing problems with pathogen transmission from various infectious surfaces to human beings. In this study, new types of highly potent antimicrobial polyurethane composite films encapsulated by hydrophobic riboflavin-based carbon polymer dots are presented. Detailed structural, optical, antimicrobial, and cytotoxic investigations of these composites were conducted. Low-power blue light triggered the composites to eradicate Escherichia coli in 30 min, whereas the same effect toward Staphylococcus aureus was reached after 60 min. These composites also show low toxicity against MRC-5 cells. In this way, RF-CPD composites can be used for sterilization of highly touched objects in the healthcare industry.",
journal = "Nanomaterials",
title = "Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots",
volume = "12",
number = "22",
pages = "4070",
doi = "10.3390/nano12224070"
}

Marković, Z. M., Kováčová, M., Jeremić, S., Nagy, Š., Milivojević, D., Kubat, P., Kleinová, A., Budimir, M., Mojsin, M., Stevanović, M. J., Annušová, A., Špitalský, Z.,& Todorović-Marković, B.. (2022). Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots. in Nanomaterials, 12(22), 4070.
https://doi.org/10.3390/nano12224070

Marković ZM, Kováčová M, Jeremić S, Nagy Š, Milivojević D, Kubat P, Kleinová A, Budimir M, Mojsin M, Stevanović MJ, Annušová A, Špitalský Z, Todorović-Marković B. Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots. in Nanomaterials. 2022;12(22):4070.
doi:10.3390/nano12224070 .

Marković, Zoran M., Kováčová, Mária, Jeremić, Sanja, Nagy, Štefan, Milivojević, Dušan, Kubat, Pavel, Kleinová, Angela, Budimir, Milica, Mojsin, Marija, Stevanović, Milena J., Annušová, Adriana, Špitalský, Zdeno, Todorović-Marković, Biljana, "Highly Efficient Antibacterial Polymer Composites Based on Hydrophobic Riboflavin Carbon Polymerized Dots" in Nanomaterials, 12, no. 22 (2022):4070,
https://doi.org/10.3390/nano12224070 . .

TY  - JOUR
AU  - Dorontić, Slađana
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Mojsin, Marija
AU  - Stevanović, Milena J.
AU  - Marković, Olivera
AU  - Jovanović, Svetlana P.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10440
AB  - Large amounts of hazardous and toxic substances in the environment require non-toxic, cheap, easy, rapid, and sensitive methods for their detection. Blue luminescent graphene quantum dots (GQDs) were produced by electrochemical cleavage of graphite electrodes followed by gamma irradiation in the presence of ethylenediamine (EDA). Modified dots were able to detect metal ions (Co2+, Pd2+, Fe3+) due to photoluminescence quenching. The highest sensitivity was detected for the sample irradiated at a dose of 25 kGy. The limits of detection (LODs) were 1.79, 2.55, and 0.66 μmol L−1 for Co2+, Fe3+, and Pd2+, respectively. It was observed that GQDs irradiated at 200 kGy act as an ultra-sensitive turn-on probe for Malathion detection with LOD of 94 nmol L−1. Atomic force microscopy images proved the aggregation of GQDs in the presence of the investigated metal ions. Results obtained by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and LIVE/DEAD cytotoxicity test indicated that GQDs irradiated with EDA are not toxic towards MRC-5 cells, which makes them a promising, eco-friendly and safe material for sensing application.
T2  - Journal of Luminescence
T1  - Blue luminescent amino-functionalized graphene quantum dots as a responsive material for potential detection of metal ions and malathion
VL  - 252
SP  - 119311
DO  - 10.1016/j.jlumin.2022.119311
ER  - 

@article{
author = "Dorontić, Slađana and Bonasera, Aurelio and Scopelliti, Michelangelo and Mojsin, Marija and Stevanović, Milena J. and Marković, Olivera and Jovanović, Svetlana P.",
year = "2022",
abstract = "Large amounts of hazardous and toxic substances in the environment require non-toxic, cheap, easy, rapid, and sensitive methods for their detection. Blue luminescent graphene quantum dots (GQDs) were produced by electrochemical cleavage of graphite electrodes followed by gamma irradiation in the presence of ethylenediamine (EDA). Modified dots were able to detect metal ions (Co2+, Pd2+, Fe3+) due to photoluminescence quenching. The highest sensitivity was detected for the sample irradiated at a dose of 25 kGy. The limits of detection (LODs) were 1.79, 2.55, and 0.66 μmol L−1 for Co2+, Fe3+, and Pd2+, respectively. It was observed that GQDs irradiated at 200 kGy act as an ultra-sensitive turn-on probe for Malathion detection with LOD of 94 nmol L−1. Atomic force microscopy images proved the aggregation of GQDs in the presence of the investigated metal ions. Results obtained by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and LIVE/DEAD cytotoxicity test indicated that GQDs irradiated with EDA are not toxic towards MRC-5 cells, which makes them a promising, eco-friendly and safe material for sensing application.",
journal = "Journal of Luminescence",
title = "Blue luminescent amino-functionalized graphene quantum dots as a responsive material for potential detection of metal ions and malathion",
volume = "252",
pages = "119311",
doi = "10.1016/j.jlumin.2022.119311"
}

Dorontić, S., Bonasera, A., Scopelliti, M., Mojsin, M., Stevanović, M. J., Marković, O.,& Jovanović, S. P.. (2022). Blue luminescent amino-functionalized graphene quantum dots as a responsive material for potential detection of metal ions and malathion. in Journal of Luminescence, 252, 119311.
https://doi.org/10.1016/j.jlumin.2022.119311

Dorontić S, Bonasera A, Scopelliti M, Mojsin M, Stevanović MJ, Marković O, Jovanović SP. Blue luminescent amino-functionalized graphene quantum dots as a responsive material for potential detection of metal ions and malathion. in Journal of Luminescence. 2022;252:119311.
doi:10.1016/j.jlumin.2022.119311 .

Dorontić, Slađana, Bonasera, Aurelio, Scopelliti, Michelangelo, Mojsin, Marija, Stevanović, Milena J., Marković, Olivera, Jovanović, Svetlana P., "Blue luminescent amino-functionalized graphene quantum dots as a responsive material for potential detection of metal ions and malathion" in Journal of Luminescence, 252 (2022):119311,
https://doi.org/10.1016/j.jlumin.2022.119311 . .