Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment
Конференцијски прилог (Објављена верзија)
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Considering the rising concern of antibiotic resistance, developing advanced antibacterial solutions is highly needed. The ability of graphene quantum dots (GQDs) to generate reactive oxygen species (ROS) upon light exposure made them promising candidates as agents in photodynamic therapy for combatting infections, including antibiotic-resistant strains. GQDs show versatile chemical, physical, and biological properties such as high fluorescent activity, resistance to photo-bleaching, low toxicity, excellent solubility, and biocompatibility. This research focused on exploring the ability of GQDs to produce singlet oxygen under blue light exposure. We used two singlet oxygen probes, 9,10-anthracenediylbis(methylene) dimalonic acid and 1,3-diphenylisobenzofuran to study photoinduced production radicals from several GQDs. To tune the ability of GQDs to generate ROS, we used gamma irradiation in two different media, the presence of L-cysteine and cyclopentanone. The results showed improveme...nts in singlet oxygen production in both cases. However, the modification conducted with cyclopentanol showed notably higher efficacy in promoting singlet oxygen production. This research demonstrates the increasing significance of GQDs in discovering new methods to combat bacteria. The modification of GQDs with gamma irradiation leads to increased production of singlet oxygen enhancing the effectiveness of photodynamic therapy for treating infections.
Извор:
21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts, 2023, 49-49Издавач:
- Belgrade : Institute of Technical Sciences of SASA
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- PHOTOGUN4MICROBES - Are photoactive nanoparticles salvation for global infectional treath? (RS-ScienceFundRS-Ideje-7741955)
Напомена:
- Twenty-First Young Researchers’ Conference - Materials Science and Engineering: Program and the Book of Abstracts; November 29 – December 1, 2023, Belgrade, Serbia
Колекције
Институција/група
VinčaTY - CONF AU - Milenković, Mila AU - Dorontić, Slađana AU - Todorović Marković, Biljana AU - Jovanović, Svetlana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12322 AB - Considering the rising concern of antibiotic resistance, developing advanced antibacterial solutions is highly needed. The ability of graphene quantum dots (GQDs) to generate reactive oxygen species (ROS) upon light exposure made them promising candidates as agents in photodynamic therapy for combatting infections, including antibiotic-resistant strains. GQDs show versatile chemical, physical, and biological properties such as high fluorescent activity, resistance to photo-bleaching, low toxicity, excellent solubility, and biocompatibility. This research focused on exploring the ability of GQDs to produce singlet oxygen under blue light exposure. We used two singlet oxygen probes, 9,10-anthracenediylbis(methylene) dimalonic acid and 1,3-diphenylisobenzofuran to study photoinduced production radicals from several GQDs. To tune the ability of GQDs to generate ROS, we used gamma irradiation in two different media, the presence of L-cysteine and cyclopentanone. The results showed improvements in singlet oxygen production in both cases. However, the modification conducted with cyclopentanol showed notably higher efficacy in promoting singlet oxygen production. This research demonstrates the increasing significance of GQDs in discovering new methods to combat bacteria. The modification of GQDs with gamma irradiation leads to increased production of singlet oxygen enhancing the effectiveness of photodynamic therapy for treating infections. PB - Belgrade : Institute of Technical Sciences of SASA C3 - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts T1 - Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment SP - 49 EP - 49 UR - https://hdl.handle.net/21.15107/rcub_vinar_12322 ER -
@conference{ author = "Milenković, Mila and Dorontić, Slađana and Todorović Marković, Biljana and Jovanović, Svetlana", year = "2023", abstract = "Considering the rising concern of antibiotic resistance, developing advanced antibacterial solutions is highly needed. The ability of graphene quantum dots (GQDs) to generate reactive oxygen species (ROS) upon light exposure made them promising candidates as agents in photodynamic therapy for combatting infections, including antibiotic-resistant strains. GQDs show versatile chemical, physical, and biological properties such as high fluorescent activity, resistance to photo-bleaching, low toxicity, excellent solubility, and biocompatibility. This research focused on exploring the ability of GQDs to produce singlet oxygen under blue light exposure. We used two singlet oxygen probes, 9,10-anthracenediylbis(methylene) dimalonic acid and 1,3-diphenylisobenzofuran to study photoinduced production radicals from several GQDs. To tune the ability of GQDs to generate ROS, we used gamma irradiation in two different media, the presence of L-cysteine and cyclopentanone. The results showed improvements in singlet oxygen production in both cases. However, the modification conducted with cyclopentanol showed notably higher efficacy in promoting singlet oxygen production. This research demonstrates the increasing significance of GQDs in discovering new methods to combat bacteria. The modification of GQDs with gamma irradiation leads to increased production of singlet oxygen enhancing the effectiveness of photodynamic therapy for treating infections.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts", title = "Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment", pages = "49-49", url = "https://hdl.handle.net/21.15107/rcub_vinar_12322" }
Milenković, M., Dorontić, S., Todorović Marković, B.,& Jovanović, S.. (2023). Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts Belgrade : Institute of Technical Sciences of SASA., 49-49. https://hdl.handle.net/21.15107/rcub_vinar_12322
Milenković M, Dorontić S, Todorović Marković B, Jovanović S. Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:49-49. https://hdl.handle.net/21.15107/rcub_vinar_12322 .
Milenković, Mila, Dorontić, Slađana, Todorović Marković, Biljana, Jovanović, Svetlana, "Innovative modifications of graphene quantum dots for improved photodynamic therapy in antibacterial treatment" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):49-49, https://hdl.handle.net/21.15107/rcub_vinar_12322 .