Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria
Аутори
Marković, Zoran M.![](/themes/MirageVinar/images/orcid.png)
Mišović, Aleksandra
![](/themes/MirageVinar/images/orcid.png)
Zmejkoski, Danica
![](/themes/MirageVinar/images/orcid.png)
Zdravković, Nemanja M.
![](/themes/MirageVinar/images/orcid.png)
Kovač, Janez
![](/themes/MirageVinar/images/orcid.png)
Bajuk-Bogdanović, Danica
![](/themes/MirageVinar/images/orcid.png)
Milivojević, Dušan
![](/themes/MirageVinar/images/orcid.png)
Mojsin, Marija
![](/themes/MirageVinar/images/orcid.png)
Stevanović, Milena
![](/themes/MirageVinar/images/orcid.png)
Pavlović, Vladimir B.
![](/themes/MirageVinar/images/orcid.png)
Todorović-Marković, Biljana
![](/themes/MirageVinar/images/orcid.png)
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Nowadays, it is a great challenge to develop new medicines for treating various infectious diseases. The treatment of these diseases is of utmost interest to further prevent the development of multi-drug resistance in different pathogens. Carbon quantum dots, as a new member of the carbon nanomaterials family, can potentially be used as a highly promising visible-light-triggered antibacterial agent. In this work, the results of antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots are presented. Carbon quantum dots (CQDs) were synthesized from citric acid by a pyrolysis procedure and irradiated by gamma rays at different doses (25, 50, 100 and 200 kGy). Structure, chemical composition and optical properties were investigated by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Vis spectrometry and photoluminescence. Structural analysis showed that CQDs... have a spherical-like shape and dose-dependent average diameters and heights. Antibacterial tests showed that all irradiated dots had antibacterial activity but CQDs irradiated with dose of 100 kGy had antibacterial activity against all seven pathogen-reference bacterial strains. Gamma-ray-modified CQDs did not show any cytotoxicity toward human fetal-originated MRC-5 cells. Moreover, fluorescence microscopy showed excellent cellular uptake of CQDs irradiated with doses of 25 and 200 kGy into MRC-5 cells.
Кључне речи:
antibacterial activity / carbon quantum dots / cellular uptake / gamma raysИзвор:
Antibiotics, 2023, 12, 5, 919-Финансирање / пројекти:
- PHOTOGUN4MICROBES - Are photoactive nanoparticles salvation for global infectional treath? (RS-ScienceFundRS-Ideje-7741955)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-MESTD-inst-2020-200042)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200146 (Универзитет у Београду, Факултет за физичку хемију) (RS-MESTD-inst-2020-200146)
- Slovenian Research Agency [research core funding No. P2-0082] and Slovenian-Serbian bilateral project [Grant number BI-RS/20-21-006].
Колекције
Институција/група
VinčaTY - JOUR AU - Marković, Zoran M. AU - Mišović, Aleksandra AU - Zmejkoski, Danica AU - Zdravković, Nemanja M. AU - Kovač, Janez AU - Bajuk-Bogdanović, Danica AU - Milivojević, Dušan AU - Mojsin, Marija AU - Stevanović, Milena AU - Pavlović, Vladimir B. AU - Todorović-Marković, Biljana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11075 AB - Nowadays, it is a great challenge to develop new medicines for treating various infectious diseases. The treatment of these diseases is of utmost interest to further prevent the development of multi-drug resistance in different pathogens. Carbon quantum dots, as a new member of the carbon nanomaterials family, can potentially be used as a highly promising visible-light-triggered antibacterial agent. In this work, the results of antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots are presented. Carbon quantum dots (CQDs) were synthesized from citric acid by a pyrolysis procedure and irradiated by gamma rays at different doses (25, 50, 100 and 200 kGy). Structure, chemical composition and optical properties were investigated by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Vis spectrometry and photoluminescence. Structural analysis showed that CQDs have a spherical-like shape and dose-dependent average diameters and heights. Antibacterial tests showed that all irradiated dots had antibacterial activity but CQDs irradiated with dose of 100 kGy had antibacterial activity against all seven pathogen-reference bacterial strains. Gamma-ray-modified CQDs did not show any cytotoxicity toward human fetal-originated MRC-5 cells. Moreover, fluorescence microscopy showed excellent cellular uptake of CQDs irradiated with doses of 25 and 200 kGy into MRC-5 cells. T2 - Antibiotics T1 - Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria VL - 12 IS - 5 SP - 919 DO - 10.3390/antibiotics12050919 ER -
@article{ author = "Marković, Zoran M. and Mišović, Aleksandra and Zmejkoski, Danica and Zdravković, Nemanja M. and Kovač, Janez and Bajuk-Bogdanović, Danica and Milivojević, Dušan and Mojsin, Marija and Stevanović, Milena and Pavlović, Vladimir B. and Todorović-Marković, Biljana", year = "2023", abstract = "Nowadays, it is a great challenge to develop new medicines for treating various infectious diseases. The treatment of these diseases is of utmost interest to further prevent the development of multi-drug resistance in different pathogens. Carbon quantum dots, as a new member of the carbon nanomaterials family, can potentially be used as a highly promising visible-light-triggered antibacterial agent. In this work, the results of antibacterial and cytotoxic activities of gamma-ray-irradiated carbon quantum dots are presented. Carbon quantum dots (CQDs) were synthesized from citric acid by a pyrolysis procedure and irradiated by gamma rays at different doses (25, 50, 100 and 200 kGy). Structure, chemical composition and optical properties were investigated by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Vis spectrometry and photoluminescence. Structural analysis showed that CQDs have a spherical-like shape and dose-dependent average diameters and heights. Antibacterial tests showed that all irradiated dots had antibacterial activity but CQDs irradiated with dose of 100 kGy had antibacterial activity against all seven pathogen-reference bacterial strains. Gamma-ray-modified CQDs did not show any cytotoxicity toward human fetal-originated MRC-5 cells. Moreover, fluorescence microscopy showed excellent cellular uptake of CQDs irradiated with doses of 25 and 200 kGy into MRC-5 cells.", journal = "Antibiotics", title = "Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria", volume = "12", number = "5", pages = "919", doi = "10.3390/antibiotics12050919" }
Marković, Z. M., Mišović, A., Zmejkoski, D., Zdravković, N. M., Kovač, J., Bajuk-Bogdanović, D., Milivojević, D., Mojsin, M., Stevanović, M., Pavlović, V. B.,& Todorović-Marković, B.. (2023). Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics, 12(5), 919. https://doi.org/10.3390/antibiotics12050919
Marković ZM, Mišović A, Zmejkoski D, Zdravković NM, Kovač J, Bajuk-Bogdanović D, Milivojević D, Mojsin M, Stevanović M, Pavlović VB, Todorović-Marković B. Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria. in Antibiotics. 2023;12(5):919. doi:10.3390/antibiotics12050919 .
Marković, Zoran M., Mišović, Aleksandra, Zmejkoski, Danica, Zdravković, Nemanja M., Kovač, Janez, Bajuk-Bogdanović, Danica, Milivojević, Dušan, Mojsin, Marija, Stevanović, Milena, Pavlović, Vladimir B., Todorović-Marković, Biljana, "Employing Gamma-Ray-Modified Carbon Quantum Dots to Combat a Wide Range of Bacteria" in Antibiotics, 12, no. 5 (2023):919, https://doi.org/10.3390/antibiotics12050919 . .