@conference{
author = "Čolović, Mirjana and Savić, N. and Parac-Vogt, Tatjana and Krstić, Danijela",
year = "2023",
abstract = "Polyoxometalates are negatively charged polyanions containing early transition metal ions in their high oxidation state surrounded by bridged oxygen. Firstly, these metal-based clusters were used as promising agents in electron-dense imaging, separations, catalysis, and analysis. In recent years, numerous studies in vitro and in vivo found that these nanocomplexes possess a variety of biological effects including antidiabetic, anticancer, and antibiotic actions. Despite these observed properties, the mechanism of their biological activities has not been completely elucidated so far. On the other hand, the results of enzymatic studies revealed their inhibiting influence on physiologically important extracellular enzymes such as phosphatases, esterases, and ecto-nucleotidases, which are considered target enzymes for the approved biological actions. Accordingly, the overview of the in vitro influence of selected polyoxo-vanadates, -tungstates, and – palladates on cholinesterase, ATPase, and phosphatase activities will be given in this presentation. Cholinesterases, enzymes located on the postsynaptic plasma membrane, have a key role in nerve impulse transmission and were confirmed as the targets of drugs for neurological diseases, which are regularly used in clinical practice. Moreover, ATPases and phosphatases were found to be included in the proliferation and migration of tumor cells, thus the inhibition of these enzymes was found as the mechanism of some anticancer drug action",
journal = "Medical Research : Medicinska istraživanja",
title = "Enzymes as a platform for drug development",
volume = "56",
number = "4",
pages = "130-130",
doi = "10.5937/medi56-47579"
}