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Tally-2.0: upgraded validator of tandem repeat detection in protein sequences
(Bioinformatics, 2020)
Motivation: Proteins containing tandem repeats (TRs) are abundant, frequently fold in elongated non-globular structures and perform vital functions. A number of computational tools have been developed to detect TRs in ...
Direct-acting antiviral drugs for treatment of hepatitis C virus infection-clinical trials data and chemistry of NS3/4A protease inhibitors
(Frontiers in Clinical Drug Research - Anti Infectives, 2020)
The hepatitis C virus (HCV) infection is a major and rising global health problem, affecting more than 71 million people worldwide. HCV is connected with several hepatic and extrahepatic disorders, containing several ...
In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine
(Antiviral Therapy, 2020)
Background: Due to the limitations of current antiviral therapies because of drug resistance and the emergence of new circulating viral strains, novel effective antivirals are urgently needed. Results of the previous drug ...
Simple criterion for selection of flavonoid compounds with anti-HIV activity
(Bioorganic and Medicinal Chemistry Letters, 2007)
Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criterion to discriminate ...
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin
(Bioorganic and Medicinal Chemistry, 2016)
The clonidine-like central antihypertensive agent rilmenidine, which has high affinity for I-1-type imidazoline receptors (I-1-IR) was recently found to have cytotoxic effects on cultured cancer cell lines. However, due ...
Recent Advances in Electrochemical Determination of Pesticides
(Journal of Nanoscience and Nanotechnology, 2021)
Widespread usage of pesticides in agricultural practice caused their residues to appear in water and food products intended for human consumption. The potential toxicity of these resources has raised awareness about pesticide ...
Development of modified pyrophyllite carbon paste electrode for carbendazim detection
(Materials and Manufacturing Processes, 2023)
This study aims to design the pyrophyllite-adapted carbon paste electrode (pCPE) and test it for potential use in wastewater purification systems. Structural characterization of pure pyrophyllite ore and mechanically ...
Multiwalled carbon nanotubes modified with MoO2 nanoparticles for voltammetric determination of the pesticide oxyfluorfen
(Microchimica Acta, 2020)
A glassy carbon electrode was functionalized by MoO2 nanoparticle–decorated multiwalled carbon nanotubes (MWCNTs) and examined as a working electrode in oxyfluorfen (OXY) detection by differential pulse stripping voltammetry ...