Simple criterion for selection of flavonoid compounds with anti-HIV activity
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Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criterion to discriminate active from inactive flavonoids that is suitable for rapid in silico screening of flavonoid libraries, and selection and optimization of lead compounds with anti-HIV-1 activity. (c) 2007 Elsevier Ltd. All rights reserved.
Кључне речи:flavonoids / in silico screening / anti-HIV compounds
Извор:Bioorganic and Medicinal Chemistry Letters, 2007, 17, 5, 1226-1232
ISSN: 0960-894X (print)