In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine
Само за регистроване кориснике
2020
Аутори
Matejin, StanislavaBukreyeva, Natalya
Radošević, Draginja
Senćanski, Milan V.
Mantlo, Emily
Veljković, Veljko
Glišić, Sanja
Paessler, Slobodan
Чланак у часопису (Објављена верзија)
,
©2019 International Medical Press
Метаподаци
Приказ свих података о документуАпстракт
Background: Due to the limitations of current antiviral therapies because of drug resistance and the emergence of new circulating viral strains, novel effective antivirals are urgently needed. Results of the previous drug repurposing by virtual screening of DrugBank revealed the anticholinergic drug cycrimine as a possible inhibitor of the influenza virus infection. Methods: In this study we examined the potential antiviral activity of cycrimine in vitro. Results: The experimental results showed the anti-influenza activity of cycrimine against two different influenza A subtypes in cell culture. Conclusions: The findings of this study suggest cycrimine as a potential therapeutic agent for influenza. ©2019 International Medical Press.
Извор:
Antiviral Therapy, 2020, 24, 8, 589-593Финансирање / пројекти:
- Примена EIIP/ISM биоинформатичке платформе у откривању нових терапеутских таргета и потенцијалних терапеутских молекула (RS-MESTD-Basic Research (BR or ON)-173001)
Институција/група
VinčaTY - JOUR AU - Matejin, Stanislava AU - Bukreyeva, Natalya AU - Radošević, Draginja AU - Senćanski, Milan V. AU - Mantlo, Emily AU - Veljković, Veljko AU - Glišić, Sanja AU - Paessler, Slobodan PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9036 AB - Background: Due to the limitations of current antiviral therapies because of drug resistance and the emergence of new circulating viral strains, novel effective antivirals are urgently needed. Results of the previous drug repurposing by virtual screening of DrugBank revealed the anticholinergic drug cycrimine as a possible inhibitor of the influenza virus infection. Methods: In this study we examined the potential antiviral activity of cycrimine in vitro. Results: The experimental results showed the anti-influenza activity of cycrimine against two different influenza A subtypes in cell culture. Conclusions: The findings of this study suggest cycrimine as a potential therapeutic agent for influenza. ©2019 International Medical Press. T2 - Antiviral Therapy T1 - In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine VL - 24 IS - 8 SP - 589 EP - 593 DO - 10.3851/IMP3348 ER -
@article{ author = "Matejin, Stanislava and Bukreyeva, Natalya and Radošević, Draginja and Senćanski, Milan V. and Mantlo, Emily and Veljković, Veljko and Glišić, Sanja and Paessler, Slobodan", year = "2020", abstract = "Background: Due to the limitations of current antiviral therapies because of drug resistance and the emergence of new circulating viral strains, novel effective antivirals are urgently needed. Results of the previous drug repurposing by virtual screening of DrugBank revealed the anticholinergic drug cycrimine as a possible inhibitor of the influenza virus infection. Methods: In this study we examined the potential antiviral activity of cycrimine in vitro. Results: The experimental results showed the anti-influenza activity of cycrimine against two different influenza A subtypes in cell culture. Conclusions: The findings of this study suggest cycrimine as a potential therapeutic agent for influenza. ©2019 International Medical Press.", journal = "Antiviral Therapy", title = "In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine", volume = "24", number = "8", pages = "589-593", doi = "10.3851/IMP3348" }
Matejin, S., Bukreyeva, N., Radošević, D., Senćanski, M. V., Mantlo, E., Veljković, V., Glišić, S.,& Paessler, S.. (2020). In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine. in Antiviral Therapy, 24(8), 589-593. https://doi.org/10.3851/IMP3348
Matejin S, Bukreyeva N, Radošević D, Senćanski MV, Mantlo E, Veljković V, Glišić S, Paessler S. In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine. in Antiviral Therapy. 2020;24(8):589-593. doi:10.3851/IMP3348 .
Matejin, Stanislava, Bukreyeva, Natalya, Radošević, Draginja, Senćanski, Milan V., Mantlo, Emily, Veljković, Veljko, Glišić, Sanja, Paessler, Slobodan, "In vitro anti-influenza activity of in silico repurposed candidate drug Cycrimine" in Antiviral Therapy, 24, no. 8 (2020):589-593, https://doi.org/10.3851/IMP3348 . .