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Inhibition of Mitochondrial Na-Dependent Ca2+ Efflux from Rat Brain Stem By 17 Beta-Estradiol
dc.creator | Petrović, Snježana | |
dc.creator | Milošević, Maja | |
dc.creator | Stanojević, Ivana | |
dc.creator | Velickovic, Natasa | |
dc.creator | Drakulić, Dunja R. | |
dc.creator | Horvat, Anica | |
dc.date.accessioned | 2018-03-01T20:51:55Z | |
dc.date.available | 2018-03-01T20:51:55Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0354-4664 | |
dc.identifier.issn | 1821-4339 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3749 | |
dc.description.abstract | The role of membrane-bound estradiol in modulation of mitochondrial Ca2+ flux in nerve endings isolated from rat brain stem was examined. Physiological concentrations of 17 beta-estradiol bind specifically to isolated mitochondria (Bmax 33.8 +/- 2.5 fmoles estradiol/mg of protein, Km 0.185 +/- 0.006 nmoles/l free estradiol). At concentrations ranging from 1 x 10-10 to 2 x 10-9 moles/l, estradiol significantly (by 23-28%) decreases mitochondrial Na-dependent calcium efflux. Decreased calcium efflux was associated with increased affinity of the Na+/Ca2+ exchanger for Na+ and decreased capacity of the exchanger to extrude Ca2+. Calcium ion efflux modulation and mitochondrial ion retention may be the way that 17 beta-estradiol exerts its role in nerve cell homeostasis. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143044/RS// | |
dc.rights | openAccess | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Archives of Biological Sciences | en |
dc.subject | mitochondria | en |
dc.subject | estradiol | en |
dc.subject | Ca2+ influx | en |
dc.subject | Ca2+ efflux | en |
dc.title | Inhibition of Mitochondrial Na-Dependent Ca2+ Efflux from Rat Brain Stem By 17 Beta-Estradiol | en |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Милошевић Маја; Дракулић Дуња; Хорват, Aница; Петровиц, Сњезана; Станојевиц, Ивана; Велицковиц, Натаса; | |
dc.citation.volume | 61 | |
dc.citation.issue | 2 | |
dc.citation.spage | 171 | |
dc.citation.epage | 177 | |
dc.identifier.wos | 000268316000003 | |
dc.identifier.doi | 10.2298/ABS0902171P | |
dc.citation.rank | M23 | |
dc.type.version | publishedVersion | |
dc.identifier.fulltext | http://vinar.vin.bg.ac.rs/bitstream/id/30010/0354-46640902171P.pdf |