The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.
Keywords:
antioxidant activity / cyclic voltammetry / cytotoxic activity / in vitro digestion / Red wine
TY - JOUR
AU - Đorđević, Neda O.
AU - Stanisavljević, Nemanja
AU - Todorović Vukotić, Nevena
AU - Novović, Katarina
AU - Žakula, Jelena
AU - Stanković, Dalibor M.
AU - Pajović, Snežana B.
PY - 2022
UR - https://vinar.vin.bg.ac.rs/handle/123456789/10353
AB - The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.
T2 - Natural Product Research
T1 - Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix
SP - 1
EP - 6
DO - 10.1080/14786419.2022.2095380
ER -
@article{
author = "Đorđević, Neda O. and Stanisavljević, Nemanja and Todorović Vukotić, Nevena and Novović, Katarina and Žakula, Jelena and Stanković, Dalibor M. and Pajović, Snežana B.",
year = "2022",
abstract = "The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.",
journal = "Natural Product Research",
title = "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix",
pages = "1-6",
doi = "10.1080/14786419.2022.2095380"
}
Đorđević, N. O., Stanisavljević, N., Todorović Vukotić, N., Novović, K., Žakula, J., Stanković, D. M.,& Pajović, S. B.. (2022). Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research, 1-6.
https://doi.org/10.1080/14786419.2022.2095380
Đorđević NO, Stanisavljević N, Todorović Vukotić N, Novović K, Žakula J, Stanković DM, Pajović SB. Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research. 2022;:1-6.
doi:10.1080/14786419.2022.2095380 .
Đorđević, Neda O., Stanisavljević, Nemanja, Todorović Vukotić, Nevena, Novović, Katarina, Žakula, Jelena, Stanković, Dalibor M., Pajović, Snežana B., "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix" in Natural Product Research (2022):1-6,
https://doi.org/10.1080/14786419.2022.2095380 . .
