Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix
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Đorđević, Neda O.Stanisavljević, Nemanja
Todorović Vukotić, Nevena
Novović, Katarina
Žakula, Jelena
Stanković, Dalibor M.
Pajović, Snežana B.
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The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.
Keywords:
antioxidant activity / cyclic voltammetry / cytotoxic activity / in vitro digestion / Red wineSource:
Natural Product Research, 2022, 1-6Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-MESTD-inst-2020-200017)
DOI: 10.1080/14786419.2022.2095380
ISSN: 1478-6427
WoS: 00082525120000
Scopus: 2-s2.0-85133519942
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VinčaTY - JOUR AU - Đorđević, Neda O. AU - Stanisavljević, Nemanja AU - Todorović Vukotić, Nevena AU - Novović, Katarina AU - Žakula, Jelena AU - Stanković, Dalibor M. AU - Pajović, Snežana B. PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10353 AB - The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion. T2 - Natural Product Research T1 - Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix SP - 1 EP - 6 DO - 10.1080/14786419.2022.2095380 ER -
@article{ author = "Đorđević, Neda O. and Stanisavljević, Nemanja and Todorović Vukotić, Nevena and Novović, Katarina and Žakula, Jelena and Stanković, Dalibor M. and Pajović, Snežana B.", year = "2022", abstract = "The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.", journal = "Natural Product Research", title = "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix", pages = "1-6", doi = "10.1080/14786419.2022.2095380" }
Đorđević, N. O., Stanisavljević, N., Todorović Vukotić, N., Novović, K., Žakula, J., Stanković, D. M.,& Pajović, S. B.. (2022). Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research, 1-6. https://doi.org/10.1080/14786419.2022.2095380
Đorđević NO, Stanisavljević N, Todorović Vukotić N, Novović K, Žakula J, Stanković DM, Pajović SB. Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research. 2022;:1-6. doi:10.1080/14786419.2022.2095380 .
Đorđević, Neda O., Stanisavljević, Nemanja, Todorović Vukotić, Nevena, Novović, Katarina, Žakula, Jelena, Stanković, Dalibor M., Pajović, Snežana B., "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix" in Natural Product Research (2022):1-6, https://doi.org/10.1080/14786419.2022.2095380 . .