TY  - JOUR
AU  - Kuljanin, Jadranka Ž.
AU  - Janković, Ivana A.
AU  - Nedeljković, Jovan
AU  - Prstojevic, D
AU  - Marinkovic, V
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2527
AB  - The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log K(ave) = 4.50 (SD = 0.15), indicating that the Fe(III)-alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1-162.5 mug ml(-1), the detection limit being 2 mug ml(-1). The method was validated for the direct determination of alendronate in tablet dosage formulations. (C) 2002 Elsevier Science B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions
VL  - 28
IS  - 6
SP  - 1215
EP  - 1220
DO  - 10.1016/S0731-7085(02)00021-3
ER  - 

@article{
author = "Kuljanin, Jadranka Ž. and Janković, Ivana A. and Nedeljković, Jovan and Prstojevic, D and Marinkovic, V",
year = "2002",
abstract = "The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log K(ave) = 4.50 (SD = 0.15), indicating that the Fe(III)-alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1-162.5 mug ml(-1), the detection limit being 2 mug ml(-1). The method was validated for the direct determination of alendronate in tablet dosage formulations. (C) 2002 Elsevier Science B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions",
volume = "28",
number = "6",
pages = "1215-1220",
doi = "10.1016/S0731-7085(02)00021-3"
}

Kuljanin, J. Ž., Janković, I. A., Nedeljković, J., Prstojevic, D.,& Marinkovic, V.. (2002). Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions. in Journal of Pharmaceutical and Biomedical Analysis, 28(6), 1215-1220.
https://doi.org/10.1016/S0731-7085(02)00021-3

Kuljanin JŽ, Janković IA, Nedeljković J, Prstojevic D, Marinkovic V. Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions. in Journal of Pharmaceutical and Biomedical Analysis. 2002;28(6):1215-1220.
doi:10.1016/S0731-7085(02)00021-3 .

Kuljanin, Jadranka Ž., Janković, Ivana A., Nedeljković, Jovan, Prstojevic, D, Marinkovic, V, "Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions" in Journal of Pharmaceutical and Biomedical Analysis, 28, no. 6 (2002):1215-1220,
https://doi.org/10.1016/S0731-7085(02)00021-3 . .

TY  - JOUR
AU  - Marinkovic, V
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Čomor, Jožef J.
AU  - Zivanov-Stakic, D
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2337
AB  - The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved.
T2  - Il Farmaco
T1  - UV derivative spectrophotometric study of the photochemical degradation of nisoldipine
VL  - 55
IS  - 2
SP  - 128
EP  - 133
DO  - 10.1016/S0014-827X(00)00004-5
ER  - 

@article{
author = "Marinkovic, V and Agbaba, Danica and Karljiković-Rajić, Katarina and Čomor, Jožef J. and Zivanov-Stakic, D",
year = "2000",
abstract = "The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively). (C) 2000 Elsevier Science S.A. All rights reserved.",
journal = "Il Farmaco",
title = "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine",
volume = "55",
number = "2",
pages = "128-133",
doi = "10.1016/S0014-827X(00)00004-5"
}

Marinkovic, V., Agbaba, D., Karljiković-Rajić, K., Čomor, J. J.,& Zivanov-Stakic, D.. (2000). UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Il Farmaco, 55(2), 128-133.
https://doi.org/10.1016/S0014-827X(00)00004-5

Marinkovic V, Agbaba D, Karljiković-Rajić K, Čomor JJ, Zivanov-Stakic D. UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Il Farmaco. 2000;55(2):128-133.
doi:10.1016/S0014-827X(00)00004-5 .

Marinkovic, V, Agbaba, Danica, Karljiković-Rajić, Katarina, Čomor, Jožef J., Zivanov-Stakic, D, "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine" in Il Farmaco, 55, no. 2 (2000):128-133,
https://doi.org/10.1016/S0014-827X(00)00004-5 . .