Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions
Апстракт
The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log K(ave) = 4.50 (SD = 0.15), indicating that the Fe(III)-alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1-162.5 mug ml(-1), the detection limit being 2 mug ml(-1). The method was validated for the direct determination of alendronate in tablet dosage formulations. (C) 2002 Elsevier Science B.V. All rights reserved.
Кључне речи:
complex formation / alendronate / iron(III) chloride / spectrophotometryИзвор:
Journal of Pharmaceutical and Biomedical Analysis, 2002, 28, 6, 1215-1220
DOI: 10.1016/S0731-7085(02)00021-3
ISSN: 0731-7085
PubMed: 12049986
WoS: 000176238300019
Scopus: 2-s2.0-0037097705
Колекције
Институција/група
VinčaTY - JOUR AU - Kuljanin, Jadranka Ž. AU - Janković, Ivana A. AU - Nedeljković, Jovan AU - Prstojevic, D AU - Marinkovic, V PY - 2002 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2527 AB - The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log K(ave) = 4.50 (SD = 0.15), indicating that the Fe(III)-alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1-162.5 mug ml(-1), the detection limit being 2 mug ml(-1). The method was validated for the direct determination of alendronate in tablet dosage formulations. (C) 2002 Elsevier Science B.V. All rights reserved. T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions VL - 28 IS - 6 SP - 1215 EP - 1220 DO - 10.1016/S0731-7085(02)00021-3 ER -
@article{ author = "Kuljanin, Jadranka Ž. and Janković, Ivana A. and Nedeljković, Jovan and Prstojevic, D and Marinkovic, V", year = "2002", abstract = "The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log K(ave) = 4.50 (SD = 0.15), indicating that the Fe(III)-alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1-162.5 mug ml(-1), the detection limit being 2 mug ml(-1). The method was validated for the direct determination of alendronate in tablet dosage formulations. (C) 2002 Elsevier Science B.V. All rights reserved.", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions", volume = "28", number = "6", pages = "1215-1220", doi = "10.1016/S0731-7085(02)00021-3" }
Kuljanin, J. Ž., Janković, I. A., Nedeljković, J., Prstojevic, D.,& Marinkovic, V.. (2002). Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions. in Journal of Pharmaceutical and Biomedical Analysis, 28(6), 1215-1220. https://doi.org/10.1016/S0731-7085(02)00021-3
Kuljanin JŽ, Janković IA, Nedeljković J, Prstojevic D, Marinkovic V. Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions. in Journal of Pharmaceutical and Biomedical Analysis. 2002;28(6):1215-1220. doi:10.1016/S0731-7085(02)00021-3 .
Kuljanin, Jadranka Ž., Janković, Ivana A., Nedeljković, Jovan, Prstojevic, D, Marinkovic, V, "Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions" in Journal of Pharmaceutical and Biomedical Analysis, 28, no. 6 (2002):1215-1220, https://doi.org/10.1016/S0731-7085(02)00021-3 . .