@article{
author = "Ilić Božović, Anja and Đoković, Petar and Milanović, Zorana and Janjić, Filip and Spariosu, Kristina and Radonjić, Vladimir and Radaković, Milena and Magaš, Vladimir and Filipović, Dimitrije and Stanković, Sanja and Kovačević Filipović, Milica and Beletić, Anđelo",
year = "2023",
abstract = "Homocysteine (Hcy) was investigated as the biomarker of cardiac, renal, and gastrointestinal disordersin dogs. Data about low Hcy concentrations in the systemic inflammatory response syndrome raised a hypothesis thatHcy in dogs could be a negative acute-phase reactant. This survey compared Hcy concentrations, serum amyloid A(SAA), and the routine laboratory parameters between healthy (HD, N=6) and dogs with inflammation of differentextent: mild (dirofilariosis (DIR), N=31), moderate (babesiosis (BAB), N=12), and severe (pyometra (PYO), N=8).The BAB and PYO groups had lower Hcy er than HD. Also, the levels in the PYO group were below those in theDIRO group. SAA had the inverse pattern. Across the groups, Hcy and SAA levels correlated negatively (ρ = -0.502,P<0.001). Hcy and SAA correlated with the erythrocyte count, hematocrit, hemoglobin and mean cellular hemoglobinconcentrations, and neutrophil count, with correlations being positive for Hcy and negative for SAA. Among all dogs,hemoglobin was the only independent predictor of Hcy concentration. Hcy levels in canine infections, decreased asacute-phase reaction (APR) intensified. Also, they were related with the hematology changes accompanying the APR.Further studies will establish the clinical potential of these alterations.",
journal = "Journal of the Hellenic Veterinary Medical Society",
title = "Could homocysteine represent a negative acute phase reactant in canine infections-a pilot study?",
volume = "74",
number = "1",
pages = "5463-5470",
doi = "10.12681/jhvms.29529"
}