Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system
Аутори
Todorović, AnaPejić, Snežana
Bobić, Katarina
Milovanović, Tijana
Stanković, Sanja
Drakulić, Dunja
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.
Извор:
PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts, 2022, 73-73Издавач:
- Belgrade : Society of Physical Chemists of Serbia
Напомена:
- XVI International Conference on Fundamental and Applied Aspects of Physical Chemistry : book of abstracts, September 26-30, Belgrade
Колекције
Институција/група
VinčaTY - CONF AU - Todorović, Ana AU - Pejić, Snežana AU - Bobić, Katarina AU - Milovanović, Tijana AU - Stanković, Sanja AU - Drakulić, Dunja PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12742 AB - Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions. PB - Belgrade : Society of Physical Chemists of Serbia C3 - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts T1 - Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system SP - 73 EP - 73 UR - https://hdl.handle.net/21.15107/rcub_vinar_12742 ER -
@conference{ author = "Todorović, Ana and Pejić, Snežana and Bobić, Katarina and Milovanović, Tijana and Stanković, Sanja and Drakulić, Dunja", year = "2022", abstract = "Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.", publisher = "Belgrade : Society of Physical Chemists of Serbia", journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts", title = "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system", pages = "73-73", url = "https://hdl.handle.net/21.15107/rcub_vinar_12742" }
Todorović, A., Pejić, S., Bobić, K., Milovanović, T., Stanković, S.,& Drakulić, D.. (2022). Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts Belgrade : Society of Physical Chemists of Serbia., 73-73. https://hdl.handle.net/21.15107/rcub_vinar_12742
Todorović A, Pejić S, Bobić K, Milovanović T, Stanković S, Drakulić D. Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts. 2022;:73-73. https://hdl.handle.net/21.15107/rcub_vinar_12742 .
Todorović, Ana, Pejić, Snežana, Bobić, Katarina, Milovanović, Tijana, Stanković, Sanja, Drakulić, Dunja, "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts (2022):73-73, https://hdl.handle.net/21.15107/rcub_vinar_12742 .