The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population
Само за регистроване кориснике
2000
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
To date, no data have been available on relationship between apolipoprotein E polymorphism and lipid levels in Serbian populations. Blood samples were obtained from 591 healthy normal individuals (193 women and 398 men). A 244 bp sequence of the apolipoprotein E gene including the two polymorphic sites was amplified by polymerase chain reaction. After digestion with Hhal, DNA fragments were visualized by microplate array diagonal gel electrophoresis. In men, levels of both total and low-density lipoprotein cholesterol among the three apolipoprotein E genotype groups differed significantly (p LT 0.05). The epsilon 2 allele was associated with lower concentrations of both total and low-density lipoprotein cholesterol, where the epsilon 4 allele had the opposite effects. No significant effects of apolipoprotein E polymorphism on serum lipid levels were observed in women. The presented data could be taken into consideration in any future disease risk evaluation in this population.
Кључне речи:
apolipoprotein E (ApoE) gene / DNA polymorphism / polymerase chain reaction (PCR) / gender-specific effects / lipids / healthy populationИзвор:
Clinical Chemistry and Laboratory Medicine, 2000, 38, 6, 539-544Напомена:
- RETRACTION: The Effect of a Gender Difference in the Apolipoprotein E Gene DNA Polymorphism on Serum Lipid Levels in a Serbian Healthy Population (Retraction of Vol 38, Pg 539, 2000) https://doi.org/10.1515/cclm-2019-8899
DOI: 10.1515/CCLM.2000.079
ISSN: 1434-6621
PubMed: 10987203
WoS: 000089443900010
Scopus: 2-s2.0-0033887933
Колекције
Институција/група
VinčaTY - JOUR AU - Stanković, Sanja AU - Glišić, Sanja AU - Alavantić, Dragan PY - 2000 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2378 AB - To date, no data have been available on relationship between apolipoprotein E polymorphism and lipid levels in Serbian populations. Blood samples were obtained from 591 healthy normal individuals (193 women and 398 men). A 244 bp sequence of the apolipoprotein E gene including the two polymorphic sites was amplified by polymerase chain reaction. After digestion with Hhal, DNA fragments were visualized by microplate array diagonal gel electrophoresis. In men, levels of both total and low-density lipoprotein cholesterol among the three apolipoprotein E genotype groups differed significantly (p LT 0.05). The epsilon 2 allele was associated with lower concentrations of both total and low-density lipoprotein cholesterol, where the epsilon 4 allele had the opposite effects. No significant effects of apolipoprotein E polymorphism on serum lipid levels were observed in women. The presented data could be taken into consideration in any future disease risk evaluation in this population. T2 - Clinical Chemistry and Laboratory Medicine T1 - The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population VL - 38 IS - 6 SP - 539 EP - 544 DO - 10.1515/CCLM.2000.079 ER -
@article{ author = "Stanković, Sanja and Glišić, Sanja and Alavantić, Dragan", year = "2000", abstract = "To date, no data have been available on relationship between apolipoprotein E polymorphism and lipid levels in Serbian populations. Blood samples were obtained from 591 healthy normal individuals (193 women and 398 men). A 244 bp sequence of the apolipoprotein E gene including the two polymorphic sites was amplified by polymerase chain reaction. After digestion with Hhal, DNA fragments were visualized by microplate array diagonal gel electrophoresis. In men, levels of both total and low-density lipoprotein cholesterol among the three apolipoprotein E genotype groups differed significantly (p LT 0.05). The epsilon 2 allele was associated with lower concentrations of both total and low-density lipoprotein cholesterol, where the epsilon 4 allele had the opposite effects. No significant effects of apolipoprotein E polymorphism on serum lipid levels were observed in women. The presented data could be taken into consideration in any future disease risk evaluation in this population.", journal = "Clinical Chemistry and Laboratory Medicine", title = "The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population", volume = "38", number = "6", pages = "539-544", doi = "10.1515/CCLM.2000.079" }
Stanković, S., Glišić, S.,& Alavantić, D.. (2000). The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population. in Clinical Chemistry and Laboratory Medicine, 38(6), 539-544. https://doi.org/10.1515/CCLM.2000.079
Stanković S, Glišić S, Alavantić D. The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population. in Clinical Chemistry and Laboratory Medicine. 2000;38(6):539-544. doi:10.1515/CCLM.2000.079 .
Stanković, Sanja, Glišić, Sanja, Alavantić, Dragan, "The effect of a gender difference in the apolipoprotein E gene DNA polymorphism on serum lipid levels in a Serbian healthy population" in Clinical Chemistry and Laboratory Medicine, 38, no. 6 (2000):539-544, https://doi.org/10.1515/CCLM.2000.079 . .