TY  - CONF
AU  - Tadić, Julijana
AU  - Gazikalović, Ivana
AU  - Mašulović, Aleksandra
AU  - Svetozarević, Milica
AU  - Porobić, Slavica
AU  - Mijin, Dušan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11597
AB  - Heterociklična azo jedinjenja predstavljaju značajnu klasnu organskih sintetskih boja. Pored njihovih izuzetnih svojstava za bojenje, heterociklična azo jedinjenja imaju i biološku aktivnost. Mnoge  studije pokazuju da azo boje sa heterocikličnim fragmentima u strukturi mogu ispoljavati antibakterijska, antifungalna, antivirusna, antiinflamatorna i antikancerogena svojstva. Rezistencija mikroorganizama na postojeće antimikrobne agense predstavlja jedan odnajvećih problema u svet-skom zdravstvu. Zbog toga je razvijanje novih molekula sa antimikrobnim svojstvima kako značajno, tako i neophodno za globalno očuvanje zdravlja. U ovom radu, ispitivanje antimikrobne aktivnosti dve  Biđineli-azo  piridonske  boje  je urađeno  pomoću  metode  difuzije  na  agarnoj  podlozi.  Anti-mikrobna  svojstva  su  ispitana  prema  patogenim  sojevima  Staphylococcus  aureus  (Gram-pozitivna bakterija), Escherichia coli (Gram-negativna bakterija) i Candida albicans (oportunistički kvasac). Preliminarni rezultati istraživanja ukazali su na antimikrobni potencijal ispitivanih azo jedinjenja.
AB  - The heterocyclic azo dyes represent significant synthetic organic colorants. In addition to their exceptional coloration properties, heterocyclic azo compounds exhibit antibacterial, antifungal, an-tiviral, antioxidant, anti-inflammatory and anticancer properties. The antimicrobial resistance is one of the major problems for global public health. Therefore, finding new organic structures with anti-microbial properties represents a challenging research field. In this study, antimicrobial screening of two Biginelli-based azo pyridone dyes has been carried out. The antimicrobial activity of synthe-tized dyes wasstudied against bacteria (Staphylococcus aureus, Escherichia coli) and yeast (Candida albicans), using agar diffusion method. The preliminary research results indicate the antimicrobial potential of the investigated compounds
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) : Društvo za procesnu tehniku
C3  - 35. Međunarodni kongres o procesnoj industriji - PROCESING ′22 : zbornik radova
T1  - Ispitivanje antimikrobnih svojstava nekih biđineli-azo piridonskih boja
T1  - The antimicrobial evaluation of some biginelli-based azo pyridone dyes
SP  - 25
EP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11232
ER  - 

@conference{
author = "Tadić, Julijana and Gazikalović, Ivana and Mašulović, Aleksandra and Svetozarević, Milica and Porobić, Slavica and Mijin, Dušan",
year = "2023",
abstract = "Heterociklična azo jedinjenja predstavljaju značajnu klasnu organskih sintetskih boja. Pored njihovih izuzetnih svojstava za bojenje, heterociklična azo jedinjenja imaju i biološku aktivnost. Mnoge  studije pokazuju da azo boje sa heterocikličnim fragmentima u strukturi mogu ispoljavati antibakterijska, antifungalna, antivirusna, antiinflamatorna i antikancerogena svojstva. Rezistencija mikroorganizama na postojeće antimikrobne agense predstavlja jedan odnajvećih problema u svet-skom zdravstvu. Zbog toga je razvijanje novih molekula sa antimikrobnim svojstvima kako značajno, tako i neophodno za globalno očuvanje zdravlja. U ovom radu, ispitivanje antimikrobne aktivnosti dve  Biđineli-azo  piridonske  boje  je urađeno  pomoću  metode  difuzije  na  agarnoj  podlozi.  Anti-mikrobna  svojstva  su  ispitana  prema  patogenim  sojevima  Staphylococcus  aureus  (Gram-pozitivna bakterija), Escherichia coli (Gram-negativna bakterija) i Candida albicans (oportunistički kvasac). Preliminarni rezultati istraživanja ukazali su na antimikrobni potencijal ispitivanih azo jedinjenja., The heterocyclic azo dyes represent significant synthetic organic colorants. In addition to their exceptional coloration properties, heterocyclic azo compounds exhibit antibacterial, antifungal, an-tiviral, antioxidant, anti-inflammatory and anticancer properties. The antimicrobial resistance is one of the major problems for global public health. Therefore, finding new organic structures with anti-microbial properties represents a challenging research field. In this study, antimicrobial screening of two Biginelli-based azo pyridone dyes has been carried out. The antimicrobial activity of synthe-tized dyes wasstudied against bacteria (Staphylococcus aureus, Escherichia coli) and yeast (Candida albicans), using agar diffusion method. The preliminary research results indicate the antimicrobial potential of the investigated compounds",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) : Društvo za procesnu tehniku",
journal = "35. Međunarodni kongres o procesnoj industriji - PROCESING ′22 : zbornik radova",
title = "Ispitivanje antimikrobnih svojstava nekih biđineli-azo piridonskih boja, The antimicrobial evaluation of some biginelli-based azo pyridone dyes",
pages = "25-28",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11232"
}

Tadić, J., Gazikalović, I., Mašulović, A., Svetozarević, M., Porobić, S.,& Mijin, D.. (2023). Ispitivanje antimikrobnih svojstava nekih biđineli-azo piridonskih boja. in 35. Međunarodni kongres o procesnoj industriji - PROCESING ′22 : zbornik radova
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) : Društvo za procesnu tehniku., 25-28.
https://hdl.handle.net/21.15107/rcub_vinar_11232

Tadić J, Gazikalović I, Mašulović A, Svetozarević M, Porobić S, Mijin D. Ispitivanje antimikrobnih svojstava nekih biđineli-azo piridonskih boja. in 35. Međunarodni kongres o procesnoj industriji - PROCESING ′22 : zbornik radova. 2023;:25-28.
https://hdl.handle.net/21.15107/rcub_vinar_11232 .

Tadić, Julijana, Gazikalović, Ivana, Mašulović, Aleksandra, Svetozarević, Milica, Porobić, Slavica, Mijin, Dušan, "Ispitivanje antimikrobnih svojstava nekih biđineli-azo piridonskih boja" in 35. Međunarodni kongres o procesnoj industriji - PROCESING ′22 : zbornik radova (2023):25-28,
https://hdl.handle.net/21.15107/rcub_vinar_11232 .

TY  - CONF
AU  - Nikolić, Nataša
AU  - Porobić, Slavica
AU  - Tadić, Julijana
AU  - Vujčić, Ivica
AU  - Kojić, Marija
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12230
AB  - Polymeric materials are widely used in the chemical and optical industries, the packaging materials industry, and biomedicine. New technologies and the search for innovative and sustainable solutions have contributed to the development of polymer sensors and smart materials. Poly(vinyl-alcohol) (PVA) is a thermoplastic polymer soluble in water. It belongs to the group of non-toxic and completely biodegradable polymers, with excellent thermal and mechanical properties. Polymer-colored films have great potential as sensor systems, primarily due to their visual color change, which makes them easy to use. Azo dyes, which are used for coloring polymer films, represent the most important class of synthetic dyes, and their exceptional properties are reflected in high extinction coefficients, as well as excellent fastness to light and wet processing. Traditionally, azo dyes are used in the food and cosmetic industries, and are also used as pH indicators. In this work, in addition to the synthesis of azo pyridone dyes, polymeric films were also synthesized. The first series of films were synthesized based on PVA and newly synthesized azo dyes, and the sensory properties of the new films were tested. The second series of films were synthesized in order to test the films as dosimeters for γ-radiation, and for this reason, TTC was added to their synthesis. The dye used in the experiments were characterized by ATR-FTIR, NMR and UV-Vis spectra. The chemical structure of the synthesized films was analyzed by ATR-FTIR spectroscopy. The sensory properties of the film were tested in solutions of different pH values, while the possibility for application in dosimetry was tested at different doses of γ-radiation at the 60Co source. Changes in the color of the films were monitored spectrophotometrically by recording reflection spectra.
PB  - Niš : RAD Centre
C3  - RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
T1  - Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes
SP  - 180
EP  - 180
DO  - 10.21175/rad.abstr.book.2023.32.10
ER  - 

@conference{
author = "Nikolić, Nataša and Porobić, Slavica and Tadić, Julijana and Vujčić, Ivica and Kojić, Marija and Lađarević, Jelena and Mijin, Dušan",
year = "2023",
abstract = "Polymeric materials are widely used in the chemical and optical industries, the packaging materials industry, and biomedicine. New technologies and the search for innovative and sustainable solutions have contributed to the development of polymer sensors and smart materials. Poly(vinyl-alcohol) (PVA) is a thermoplastic polymer soluble in water. It belongs to the group of non-toxic and completely biodegradable polymers, with excellent thermal and mechanical properties. Polymer-colored films have great potential as sensor systems, primarily due to their visual color change, which makes them easy to use. Azo dyes, which are used for coloring polymer films, represent the most important class of synthetic dyes, and their exceptional properties are reflected in high extinction coefficients, as well as excellent fastness to light and wet processing. Traditionally, azo dyes are used in the food and cosmetic industries, and are also used as pH indicators. In this work, in addition to the synthesis of azo pyridone dyes, polymeric films were also synthesized. The first series of films were synthesized based on PVA and newly synthesized azo dyes, and the sensory properties of the new films were tested. The second series of films were synthesized in order to test the films as dosimeters for γ-radiation, and for this reason, TTC was added to their synthesis. The dye used in the experiments were characterized by ATR-FTIR, NMR and UV-Vis spectra. The chemical structure of the synthesized films was analyzed by ATR-FTIR spectroscopy. The sensory properties of the film were tested in solutions of different pH values, while the possibility for application in dosimetry was tested at different doses of γ-radiation at the 60Co source. Changes in the color of the films were monitored spectrophotometrically by recording reflection spectra.",
publisher = "Niš : RAD Centre",
journal = "RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts",
title = "Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes",
pages = "180-180",
doi = "10.21175/rad.abstr.book.2023.32.10"
}

Nikolić, N., Porobić, S., Tadić, J., Vujčić, I., Kojić, M., Lađarević, J.,& Mijin, D.. (2023). Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
Niš : RAD Centre., 180-180.
https://doi.org/10.21175/rad.abstr.book.2023.32.10

Nikolić N, Porobić S, Tadić J, Vujčić I, Kojić M, Lađarević J, Mijin D. Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts. 2023;:180-180.
doi:10.21175/rad.abstr.book.2023.32.10 .

Nikolić, Nataša, Porobić, Slavica, Tadić, Julijana, Vujčić, Ivica, Kojić, Marija, Lađarević, Jelena, Mijin, Dušan, "Sensory properties of new films based on poly(vinyl-alcohol) and pyridone azo dyes" in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts (2023):180-180,
https://doi.org/10.21175/rad.abstr.book.2023.32.10 . .

TY  - CONF
AU  - Nikolić, Nikolina
AU  - Spasojević, Jelena
AU  - Stamenović, Una
AU  - Vukoje, Ivana
AU  - Tadić, Julijana
AU  - Vodnik, Vesna
AU  - Kačarević-Popović, Zorica
AU  - Radosavljević, Aleksandra
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12226
PB  - Niš : RAD Centre
C3  - RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
T1  - Gamma irradiation-induced synthesis and characterization of bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposites
SP  - 85
EP  - 85
DO  - 10.21175/rad.abstr.book.2023.19.6
ER  - 

@conference{
author = "Nikolić, Nikolina and Spasojević, Jelena and Stamenović, Una and Vukoje, Ivana and Tadić, Julijana and Vodnik, Vesna and Kačarević-Popović, Zorica and Radosavljević, Aleksandra",
year = "2023",
publisher = "Niš : RAD Centre",
journal = "RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts",
title = "Gamma irradiation-induced synthesis and characterization of bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposites",
pages = "85-85",
doi = "10.21175/rad.abstr.book.2023.19.6"
}

Nikolić, N., Spasojević, J., Stamenović, U., Vukoje, I., Tadić, J., Vodnik, V., Kačarević-Popović, Z.,& Radosavljević, A.. (2023). Gamma irradiation-induced synthesis and characterization of bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposites. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts
Niš : RAD Centre., 85-85.
https://doi.org/10.21175/rad.abstr.book.2023.19.6

Nikolić N, Spasojević J, Stamenović U, Vukoje I, Tadić J, Vodnik V, Kačarević-Popović Z, Radosavljević A. Gamma irradiation-induced synthesis and characterization of bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposites. in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts. 2023;:85-85.
doi:10.21175/rad.abstr.book.2023.19.6 .

Nikolić, Nikolina, Spasojević, Jelena, Stamenović, Una, Vukoje, Ivana, Tadić, Julijana, Vodnik, Vesna, Kačarević-Popović, Zorica, Radosavljević, Aleksandra, "Gamma irradiation-induced synthesis and characterization of bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposites" in RAD 2023 : 11th International Conference on Radiation Natural Sciences, Medicine, Engineering, Technology and Ecology : Book of Abstracts (2023):85-85,
https://doi.org/10.21175/rad.abstr.book.2023.19.6 . .

TY  - CONF
AU  - Spasojević, Jelena
AU  - Vukoje, Ivana
AU  - Nikolić, Nikolina
AU  - Tadić, Julijana
AU  - Milošević, Milica
AU  - Vodnik, Vesna
AU  - Radosavljević, Aleksandra
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11595
AB  - Hydrogels  have  unique  properties  and  many  potential  applications,  particularly  in  medicine and biotechnology. Gel porosity and swelling properties, stability, and biocompatibility are charac-teristics that are widely variable and easily adjusted. Stimuli-responsive or intelligent hydrogels are a  class  of  thesematerials  that  shows  a  significant  response  to  small  changes  in  the  surrounding environment.  Poly(N-isopropylacrylamide)  (PNiPAAm)  is  the  best-known  thermosensitive  polymer with a well-defined volume phase transition temperature (VPTT) around 32C. On theother hand, silver  nanoparticles  (AgNPs)  have  been  the  subject  of  intense  interest  due  to  their  size-dependent optical,  catalytic,  and  electronic  properties  as  well  as  remarkable  antimicrobial  potential.  Within the last decade, scientists have demonstrated that anisotropic AgNPs can be synthesized in a controlled  manner  and  that  these  materials  exhibit distinctively  different  physicochemical  properties from  their  spherical  counterparts.  A  significant  challenge  that  scientists  face  is  establishing  how thesenanoparticles  can  be  used  in  a  wider  spectrum  of  practical  applications.  Therefore,  we  pre-sent  a  simple,  straightforward  two-step  synthesis  of  AgNPs/PNiPAAm  hydrogel  nanocomposites that  includes  the  chemical  formation  of  both  spherical  and  triangular  AgNPs,  followed  by  gamma irradiation-induced  PNiPAAm  crosslinking  in  the  presence  of  nanoparticles.  The  gamma  irradia-tion technique merges sterilization and synthesis in a single technological step, optimizing the pro-cess  and  opening  up  a  wide  range  of  innovative  biomedical  applications.  The  formation  of  stable and uniformly distributed AgNPs in the polymer was confirmed by UV-VIS spectroscopy, while the network porous sponge-like structure was observed by SEM analysis. Physicochemical characteri-zation  was  performed  by  examining  the  swelling  and  deswelling  processes  in  water  at  25C  and 48C,  respectively.  In  addition,  AgNPs  were  shown  to  have  an  effect  on  VPTT  values.  Our  main goal is to investigate how different morphologies of AgNPs affect the physicochemicalproperties of nanocomposite samples, considering the potential applications and the ongoing need for the wide-spread use of biocompatible materials
AB  - Hidrogelovi su materijali koji poseduju specifičnu poroznost, stabilnost, biokompatibilnost i sposobnost apsorpcije okolne tečnosti, kao i svojstva koja su promenljiva i lako podesiva širokom spektru primena, naročito u oblasti medicine i biotehnologije. Posebno je interesantna oblast “inteligentnih“ hidrogelova, odnosno materijala koji reaguju na spoljašnje stimulanse i pokazuju značajanu fizičku ili hemijsku promenu pri malim promenama u okruženju. Poli(N-izopropilakrilamid) (PNiPAAm) je najpoznatiji termosenzitivni polimer sa jasno definisanom temperaturom faznog prelaza (VPTT) od oko 32°C. S druge strane, nanočestice srebra (AgNPs) poseduju optička, katalitička i električna svojstva koja se mogu modifikovati promenom njihove veličine i oblika a imaju i izražen antibakterijski potencijal, pa su stoga, poslednjih decenija intenzivno proučavane. Pokazano je da se anizotropne nanočestice srebra mogu kontrolisano sintetisati sa fizičkohemijskim svojstvima različitim od sfernih analoga, pri čemu su značajna istraživanja usmerena na njihovu praktičnu primenu. Zbog svega navedenog, u okviru ovog istraživanja biće izvedena jednostavna dvostepena sinteza AgNPs/PNiPAAm hidrogel nanokompozita koja uključuje hemijsko formiranje sfernih i trouglastih AgNPs u prvom koraku, a zatim gama-indukovano umrežavanje NiPAAm-a u prisustvu ovih AgNPs. Tehnika gama zračenja objedinjuje sterilizaciju i sintezu u jednom tehnološkom koraku čime se proces optimizuje i otvara širok spektar inovativnih biomedicinskih primena. Formiranje stabilnih i uniformno distribuiranih AgNPs unutar matrice hidrogela potvrđeno je UV-Vis spektroskopijom, a porozna sunđerasta struktura polimerne mreže SEM analizom. Fizičkohemijska karakterizacija izvršena je i ispitivanjem procesa bubrenja i kontrahovanja u vodi na 25°C i 48°C, redom. Pored toga, pokazano je da prisustvo AgNPs utiče na vrednosti temperature faznog prelaza polimera. Osnovni cilj ovog istraživanja je ispitivanje uticaja različite morfologije AgNPs na fizičkohemijska svojstva sintetisanih nanokompozita, imajući u vidu njihovu potencijalnu primenu i stalnu potrebu za širokom upotrebom biokompatibilnih materijala.
PB  - Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) : Društvo za procesnu tehniku
C3  - 36. Međunarodni kongres o procesnoj industriji - PROCESING ′23 : zbornik radova
T1  - The effect of silver nanoparticle shape on the physicochemical properties of a poly(n-isopropylacrylamide) hydrogel nanocomposites
T1  - Uticaj oblika nanočestica srebra na fizičkohemijska svojstva poli(n-izopropilakrilamid) hidrogel nanokompozita
SP  - 197
EP  - 206
DO  - 10.24094/ptk.023.197
ER  - 

@conference{
author = "Spasojević, Jelena and Vukoje, Ivana and Nikolić, Nikolina and Tadić, Julijana and Milošević, Milica and Vodnik, Vesna and Radosavljević, Aleksandra",
year = "2023",
abstract = "Hydrogels  have  unique  properties  and  many  potential  applications,  particularly  in  medicine and biotechnology. Gel porosity and swelling properties, stability, and biocompatibility are charac-teristics that are widely variable and easily adjusted. Stimuli-responsive or intelligent hydrogels are a  class  of  thesematerials  that  shows  a  significant  response  to  small  changes  in  the  surrounding environment.  Poly(N-isopropylacrylamide)  (PNiPAAm)  is  the  best-known  thermosensitive  polymer with a well-defined volume phase transition temperature (VPTT) around 32C. On theother hand, silver  nanoparticles  (AgNPs)  have  been  the  subject  of  intense  interest  due  to  their  size-dependent optical,  catalytic,  and  electronic  properties  as  well  as  remarkable  antimicrobial  potential.  Within the last decade, scientists have demonstrated that anisotropic AgNPs can be synthesized in a controlled  manner  and  that  these  materials  exhibit distinctively  different  physicochemical  properties from  their  spherical  counterparts.  A  significant  challenge  that  scientists  face  is  establishing  how thesenanoparticles  can  be  used  in  a  wider  spectrum  of  practical  applications.  Therefore,  we  pre-sent  a  simple,  straightforward  two-step  synthesis  of  AgNPs/PNiPAAm  hydrogel  nanocomposites that  includes  the  chemical  formation  of  both  spherical  and  triangular  AgNPs,  followed  by  gamma irradiation-induced  PNiPAAm  crosslinking  in  the  presence  of  nanoparticles.  The  gamma  irradia-tion technique merges sterilization and synthesis in a single technological step, optimizing the pro-cess  and  opening  up  a  wide  range  of  innovative  biomedical  applications.  The  formation  of  stable and uniformly distributed AgNPs in the polymer was confirmed by UV-VIS spectroscopy, while the network porous sponge-like structure was observed by SEM analysis. Physicochemical characteri-zation  was  performed  by  examining  the  swelling  and  deswelling  processes  in  water  at  25C  and 48C,  respectively.  In  addition,  AgNPs  were  shown  to  have  an  effect  on  VPTT  values.  Our  main goal is to investigate how different morphologies of AgNPs affect the physicochemicalproperties of nanocomposite samples, considering the potential applications and the ongoing need for the wide-spread use of biocompatible materials, Hidrogelovi su materijali koji poseduju specifičnu poroznost, stabilnost, biokompatibilnost i sposobnost apsorpcije okolne tečnosti, kao i svojstva koja su promenljiva i lako podesiva širokom spektru primena, naročito u oblasti medicine i biotehnologije. Posebno je interesantna oblast “inteligentnih“ hidrogelova, odnosno materijala koji reaguju na spoljašnje stimulanse i pokazuju značajanu fizičku ili hemijsku promenu pri malim promenama u okruženju. Poli(N-izopropilakrilamid) (PNiPAAm) je najpoznatiji termosenzitivni polimer sa jasno definisanom temperaturom faznog prelaza (VPTT) od oko 32°C. S druge strane, nanočestice srebra (AgNPs) poseduju optička, katalitička i električna svojstva koja se mogu modifikovati promenom njihove veličine i oblika a imaju i izražen antibakterijski potencijal, pa su stoga, poslednjih decenija intenzivno proučavane. Pokazano je da se anizotropne nanočestice srebra mogu kontrolisano sintetisati sa fizičkohemijskim svojstvima različitim od sfernih analoga, pri čemu su značajna istraživanja usmerena na njihovu praktičnu primenu. Zbog svega navedenog, u okviru ovog istraživanja biće izvedena jednostavna dvostepena sinteza AgNPs/PNiPAAm hidrogel nanokompozita koja uključuje hemijsko formiranje sfernih i trouglastih AgNPs u prvom koraku, a zatim gama-indukovano umrežavanje NiPAAm-a u prisustvu ovih AgNPs. Tehnika gama zračenja objedinjuje sterilizaciju i sintezu u jednom tehnološkom koraku čime se proces optimizuje i otvara širok spektar inovativnih biomedicinskih primena. Formiranje stabilnih i uniformno distribuiranih AgNPs unutar matrice hidrogela potvrđeno je UV-Vis spektroskopijom, a porozna sunđerasta struktura polimerne mreže SEM analizom. Fizičkohemijska karakterizacija izvršena je i ispitivanjem procesa bubrenja i kontrahovanja u vodi na 25°C i 48°C, redom. Pored toga, pokazano je da prisustvo AgNPs utiče na vrednosti temperature faznog prelaza polimera. Osnovni cilj ovog istraživanja je ispitivanje uticaja različite morfologije AgNPs na fizičkohemijska svojstva sintetisanih nanokompozita, imajući u vidu njihovu potencijalnu primenu i stalnu potrebu za širokom upotrebom biokompatibilnih materijala.",
publisher = "Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) : Društvo za procesnu tehniku",
journal = "36. Međunarodni kongres o procesnoj industriji - PROCESING ′23 : zbornik radova",
title = "The effect of silver nanoparticle shape on the physicochemical properties of a poly(n-isopropylacrylamide) hydrogel nanocomposites, Uticaj oblika nanočestica srebra na fizičkohemijska svojstva poli(n-izopropilakrilamid) hidrogel nanokompozita",
pages = "197-206",
doi = "10.24094/ptk.023.197"
}

Spasojević, J., Vukoje, I., Nikolić, N., Tadić, J., Milošević, M., Vodnik, V.,& Radosavljević, A.. (2023). The effect of silver nanoparticle shape on the physicochemical properties of a poly(n-isopropylacrylamide) hydrogel nanocomposites. in 36. Međunarodni kongres o procesnoj industriji - PROCESING ′23 : zbornik radova
Beograd : Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS) : Društvo za procesnu tehniku., 197-206.
https://doi.org/10.24094/ptk.023.197

Spasojević J, Vukoje I, Nikolić N, Tadić J, Milošević M, Vodnik V, Radosavljević A. The effect of silver nanoparticle shape on the physicochemical properties of a poly(n-isopropylacrylamide) hydrogel nanocomposites. in 36. Međunarodni kongres o procesnoj industriji - PROCESING ′23 : zbornik radova. 2023;:197-206.
doi:10.24094/ptk.023.197 .

Spasojević, Jelena, Vukoje, Ivana, Nikolić, Nikolina, Tadić, Julijana, Milošević, Milica, Vodnik, Vesna, Radosavljević, Aleksandra, "The effect of silver nanoparticle shape on the physicochemical properties of a poly(n-isopropylacrylamide) hydrogel nanocomposites" in 36. Međunarodni kongres o procesnoj industriji - PROCESING ′23 : zbornik radova (2023):197-206,
https://doi.org/10.24094/ptk.023.197 . .

TY  - JOUR
AU  - Janković, Nenad
AU  - Tadić, Julijana D.
AU  - Milović, Emilija
AU  - Marković, Zoran
AU  - Jeremić, Svetlana
AU  - Petronijević, Jelena
AU  - Joksimović, Nenad
AU  - Borović, Teona Teodora
AU  - Bukhari, Syed Nasir Abbas
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11100
AB  - Antioxidants have a significant contribution in the cell protection against free radicals which may induce oxidative stress, and permanently damage the cells causing different disorders such as tumors, degenerative diseases, and accelerated aging. Nowadays, a multi-functionalized heterocyclic framework plays an important role in drug development, and it is of great importance in organic synthesis and medicinal chemistry. Encouraged by the bioactivity of the pyrido-dipyrimidine scaffold and vanillin core, herein, we made an effort to thoroughly investigate the antioxidant potential of the vanillin-based pyrido-dipyrimidines A–E to reveal novel promising free radical inhibitors. The structural analysis and the antioxidant action of the investigated molecules were performed in silico by DFT calculations. Studied compounds were screened for their antioxidant capacity using in vitro ABTS and DPPH assays. All the investigated compounds showed remarkable antioxidant activity, especially derivative A exhibiting inhibition of free radicals at the IC50 value (ABTS and DPPH assay 0.1 mg ml−1 and 0.081 mg ml−1, respectively). Compound A has higher TEAC values implying its stronger antioxidant activity compared to a trolox standard. The applied calculation method and in vitro tests confirmed that compound A has a strong potential against free radicals and may be a novel candidate for application in antioxidant therapy.
T2  - RSC Advances
T1  - Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach
VL  - 13
IS  - 22
SP  - 15236
EP  - 15242
DO  - 10.1039/D3RA02469E
ER  - 

@article{
author = "Janković, Nenad and Tadić, Julijana D. and Milović, Emilija and Marković, Zoran and Jeremić, Svetlana and Petronijević, Jelena and Joksimović, Nenad and Borović, Teona Teodora and Bukhari, Syed Nasir Abbas",
year = "2023",
abstract = "Antioxidants have a significant contribution in the cell protection against free radicals which may induce oxidative stress, and permanently damage the cells causing different disorders such as tumors, degenerative diseases, and accelerated aging. Nowadays, a multi-functionalized heterocyclic framework plays an important role in drug development, and it is of great importance in organic synthesis and medicinal chemistry. Encouraged by the bioactivity of the pyrido-dipyrimidine scaffold and vanillin core, herein, we made an effort to thoroughly investigate the antioxidant potential of the vanillin-based pyrido-dipyrimidines A–E to reveal novel promising free radical inhibitors. The structural analysis and the antioxidant action of the investigated molecules were performed in silico by DFT calculations. Studied compounds were screened for their antioxidant capacity using in vitro ABTS and DPPH assays. All the investigated compounds showed remarkable antioxidant activity, especially derivative A exhibiting inhibition of free radicals at the IC50 value (ABTS and DPPH assay 0.1 mg ml−1 and 0.081 mg ml−1, respectively). Compound A has higher TEAC values implying its stronger antioxidant activity compared to a trolox standard. The applied calculation method and in vitro tests confirmed that compound A has a strong potential against free radicals and may be a novel candidate for application in antioxidant therapy.",
journal = "RSC Advances",
title = "Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach",
volume = "13",
number = "22",
pages = "15236-15242",
doi = "10.1039/D3RA02469E"
}

Janković, N., Tadić, J. D., Milović, E., Marković, Z., Jeremić, S., Petronijević, J., Joksimović, N., Borović, T. T.,& Bukhari, S. N. A.. (2023). Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach. in RSC Advances, 13(22), 15236-15242.
https://doi.org/10.1039/D3RA02469E

Janković N, Tadić JD, Milović E, Marković Z, Jeremić S, Petronijević J, Joksimović N, Borović TT, Bukhari SNA. Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach. in RSC Advances. 2023;13(22):15236-15242.
doi:10.1039/D3RA02469E .

Janković, Nenad, Tadić, Julijana D., Milović, Emilija, Marković, Zoran, Jeremić, Svetlana, Petronijević, Jelena, Joksimović, Nenad, Borović, Teona Teodora, Bukhari, Syed Nasir Abbas, "Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach" in RSC Advances, 13, no. 22 (2023):15236-15242,
https://doi.org/10.1039/D3RA02469E . .

TY  - CONF
AU  - Jakovljević, Teodora
AU  - Stanisavljević, Jelena
AU  - Matić, Tamara
AU  - Tadić, Julijana
AU  - Veljović, Đorđe
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12301
AB  - In recent years, scientists have been working on developing biocompatible materials that closely mimic the structure and properties of natural biological tissues for their application in hard tissue regeneration and controlled drug release. Human bones and teeth primarily consist of calcium-phosphate crystals with small amounts of various ions incorporated into their crystal structure. The aim of this study was to examine the possibility of processing macroporous bioceramic scaffolds based on calcium-hydroxyapatite (HAp) doped with magnesium (Mg), strontium (Sr) and fluorine (F) ions, subsequently coated with polymer chitosan. In this study, the doped HAp powder was synthesized by a hydrothermal process, and scaffolds were made using the sponge replica method, sintered and then coated with the chitosan. The influence of dopant ions and chitosan on the scaffold's microstructure, mechanical properties, bioactivity, cytotoxicity and drug release properties was examined. Energy dispersive spectroscopy confirmed that Mg and Sr are incorporated in all powder samples, while the presence of F was confirmed in samples synthesized with 1 and 2 mol.% F in the precursor solution. The phase composition of powders and scaffolds determined by X-ray analysis showed the presence of HAp and β-tricalcium phosphate phase (β-TCP) in scaffolds. In the compressive strength (CS) test, coated scaffolds showed significantly higher CS compared to uncoated scaffolds. Scanning electron microscopy was used to examine the morphology of nanostructured powders, microstructure, and the bioactivity of the scaffolds. The uncoated scaffolds showed satisfactory bioactivity after being immersed in simulated body fluid for 28 days, while lower bioactivity was observed in the coated scaffolds due to the slow degradation of chitosan. The synthesized scaffolds also demonstrated to have a positive impact on cell viability, even slightly stimulating the cell proliferation. Additionally, scaffolds were shown to successfully release drug. In concusion, the addition of ions and chitosan polymer significantly improved the properties of the obtained scaffolds, which indicates their potential application in tissue engineering and controlled drug release.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
T1  - Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan
SP  - 2
EP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12301
ER  - 

@conference{
author = "Jakovljević, Teodora and Stanisavljević, Jelena and Matić, Tamara and Tadić, Julijana and Veljović, Đorđe",
year = "2023",
abstract = "In recent years, scientists have been working on developing biocompatible materials that closely mimic the structure and properties of natural biological tissues for their application in hard tissue regeneration and controlled drug release. Human bones and teeth primarily consist of calcium-phosphate crystals with small amounts of various ions incorporated into their crystal structure. The aim of this study was to examine the possibility of processing macroporous bioceramic scaffolds based on calcium-hydroxyapatite (HAp) doped with magnesium (Mg), strontium (Sr) and fluorine (F) ions, subsequently coated with polymer chitosan. In this study, the doped HAp powder was synthesized by a hydrothermal process, and scaffolds were made using the sponge replica method, sintered and then coated with the chitosan. The influence of dopant ions and chitosan on the scaffold's microstructure, mechanical properties, bioactivity, cytotoxicity and drug release properties was examined. Energy dispersive spectroscopy confirmed that Mg and Sr are incorporated in all powder samples, while the presence of F was confirmed in samples synthesized with 1 and 2 mol.% F in the precursor solution. The phase composition of powders and scaffolds determined by X-ray analysis showed the presence of HAp and β-tricalcium phosphate phase (β-TCP) in scaffolds. In the compressive strength (CS) test, coated scaffolds showed significantly higher CS compared to uncoated scaffolds. Scanning electron microscopy was used to examine the morphology of nanostructured powders, microstructure, and the bioactivity of the scaffolds. The uncoated scaffolds showed satisfactory bioactivity after being immersed in simulated body fluid for 28 days, while lower bioactivity was observed in the coated scaffolds due to the slow degradation of chitosan. The synthesized scaffolds also demonstrated to have a positive impact on cell viability, even slightly stimulating the cell proliferation. Additionally, scaffolds were shown to successfully release drug. In concusion, the addition of ions and chitosan polymer significantly improved the properties of the obtained scaffolds, which indicates their potential application in tissue engineering and controlled drug release.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts",
title = "Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan",
pages = "2-2",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12301"
}

Jakovljević, T., Stanisavljević, J., Matić, T., Tadić, J.,& Veljović, Đ.. (2023). Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts
Belgrade : Institute of Technical Sciences of SASA., 2-2.
https://hdl.handle.net/21.15107/rcub_vinar_12301

Jakovljević T, Stanisavljević J, Matić T, Tadić J, Veljović Đ. Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:2-2.
https://hdl.handle.net/21.15107/rcub_vinar_12301 .

Jakovljević, Teodora, Stanisavljević, Jelena, Matić, Tamara, Tadić, Julijana, Veljović, Đorđe, "Development of macroporous bioceramic materials based on multi-ion doped calcium-hydroxyapatite coated with chitosan" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):2-2,
https://hdl.handle.net/21.15107/rcub_vinar_12301 .

TY  - JOUR
AU  - Dramićanin, Miroslav
AU  - Marciniak, Lukasz
AU  - Kuzman, Sanja
AU  - Piotrowski, Wojciech
AU  - Ristić, Zoran
AU  - Periša, Jovana
AU  - Evans, Ivana
AU  - Mitrić, Jelena
AU  - Đorđević, Vesna
AU  - Tadić, Julijana D.
AU  - Brik, Mikhail G.
AU  - Ma, Chong-Geng
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10439
AB  - The near-infrared luminescence of Ca6Ba(PO4)4O:Mn5+ is demonstrated and explained. When excited into the broad and strong absorption band that spans the 500–1000 nm spectral range, this phosphor provides an ultranarrow (FWHM = 5 nm) emission centered at 1140 nm that originates from a spin-forbidden 1E → 3A2 transition with a 37.5% internal quantum efficiency and an excited-state lifetime of about 350 μs. We derived the crystal field and Racah parameters and calculated the appropriate Tanabe–Sugano diagram for this phosphor. We found that 1E emission quenches due to the thermally-assisted cross-over with the 3T2 state and that the relatively high Debye temperature of 783 K of Ca6Ba(PO4)4O facilitates efficient emission. Since Ca6Ba(PO4)4O also provides efficient yellow emission of the Eu2+ dopant, we calculated and explained its electronic band structure, the partial and total density of states, effective Mulliken charges of all ions, elastic constants, Debye temperature, and vibrational spectra. Finally, we demonstrated the application of phosphor in a luminescence intensity ratio thermometry and obtained a relative sensitivity of 1.92%K−1 and a temperature resolution of 0.2 K in the range of physiological temperatures.
T2  - Light: Science & Applications
T1  - Mn5+-activated Ca6Ba(PO4)4O near-infrared phosphor and its application in luminescence thermometry
VL  - 11
IS  - 1
SP  - 279
DO  - 10.1038/s41377-022-00958-7
ER  - 

@article{
author = "Dramićanin, Miroslav and Marciniak, Lukasz and Kuzman, Sanja and Piotrowski, Wojciech and Ristić, Zoran and Periša, Jovana and Evans, Ivana and Mitrić, Jelena and Đorđević, Vesna and Tadić, Julijana D. and Brik, Mikhail G. and Ma, Chong-Geng",
year = "2022",
abstract = "The near-infrared luminescence of Ca6Ba(PO4)4O:Mn5+ is demonstrated and explained. When excited into the broad and strong absorption band that spans the 500–1000 nm spectral range, this phosphor provides an ultranarrow (FWHM = 5 nm) emission centered at 1140 nm that originates from a spin-forbidden 1E → 3A2 transition with a 37.5% internal quantum efficiency and an excited-state lifetime of about 350 μs. We derived the crystal field and Racah parameters and calculated the appropriate Tanabe–Sugano diagram for this phosphor. We found that 1E emission quenches due to the thermally-assisted cross-over with the 3T2 state and that the relatively high Debye temperature of 783 K of Ca6Ba(PO4)4O facilitates efficient emission. Since Ca6Ba(PO4)4O also provides efficient yellow emission of the Eu2+ dopant, we calculated and explained its electronic band structure, the partial and total density of states, effective Mulliken charges of all ions, elastic constants, Debye temperature, and vibrational spectra. Finally, we demonstrated the application of phosphor in a luminescence intensity ratio thermometry and obtained a relative sensitivity of 1.92%K−1 and a temperature resolution of 0.2 K in the range of physiological temperatures.",
journal = "Light: Science & Applications",
title = "Mn5+-activated Ca6Ba(PO4)4O near-infrared phosphor and its application in luminescence thermometry",
volume = "11",
number = "1",
pages = "279",
doi = "10.1038/s41377-022-00958-7"
}

Dramićanin, M., Marciniak, L., Kuzman, S., Piotrowski, W., Ristić, Z., Periša, J., Evans, I., Mitrić, J., Đorđević, V., Tadić, J. D., Brik, M. G.,& Ma, C.. (2022). Mn5+-activated Ca6Ba(PO4)4O near-infrared phosphor and its application in luminescence thermometry. in Light: Science & Applications, 11(1), 279.
https://doi.org/10.1038/s41377-022-00958-7

Dramićanin M, Marciniak L, Kuzman S, Piotrowski W, Ristić Z, Periša J, Evans I, Mitrić J, Đorđević V, Tadić JD, Brik MG, Ma C. Mn5+-activated Ca6Ba(PO4)4O near-infrared phosphor and its application in luminescence thermometry. in Light: Science & Applications. 2022;11(1):279.
doi:10.1038/s41377-022-00958-7 .

Dramićanin, Miroslav, Marciniak, Lukasz, Kuzman, Sanja, Piotrowski, Wojciech, Ristić, Zoran, Periša, Jovana, Evans, Ivana, Mitrić, Jelena, Đorđević, Vesna, Tadić, Julijana D., Brik, Mikhail G., Ma, Chong-Geng, "Mn5+-activated Ca6Ba(PO4)4O near-infrared phosphor and its application in luminescence thermometry" in Light: Science & Applications, 11, no. 1 (2022):279,
https://doi.org/10.1038/s41377-022-00958-7 . .

TY  - JOUR
AU  - Marković, Maja D.
AU  - Tadić, Julijana D.
AU  - Savić, Sanja I.
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana P.
AU  - Mijin, Dušan Ž.
AU  - Panić, Vesna V.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10262
AB  - Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.
T2  - Journal of Biomedical Materials Research - Part A
T1  - Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment
DO  - 10.1002/jbm.a.37396
ER  - 

@article{
author = "Marković, Maja D. and Tadić, Julijana D. and Savić, Sanja I. and Matić, Ivana Z. and Stanojković, Tatjana P. and Mijin, Dušan Ž. and Panić, Vesna V.",
year = "2022",
abstract = "Researchers are faced with everyday demands for safer and more efficient therapy for many diseases, especially serious one such as various types of cancer. Numerous anticancer drugs are poorly-water soluble and therefore their encapsulation and controlled release remain quite challenge. In present study, we deepened our research of hydrophilic carrier based on poly(methacrylic acid) and casein (PMAC) by investigating its potential for encapsulation and controlled release of novel poorly water-soluble dihydropyrimidion-azo-pyridon compound (DHPMP). DHPMP is a dye that has been proven to show cytotoxic activity against chronic myeloid leukemia K562 cells. By encapsulating DHPMP into the carrier and delivering it into the intestines, DHPMP absorption could be the fastest and the number of therapeutic doses and side effects can be reduced. Carriers based on PMAC and DHPMP (PMAC-DHPMP) were synthetized and characterized by FTIR, SEM and single compression tests. The swelling behavior of PMAC-DHPMP carriers and cumulative DHPMP release were investigated depending on the amount of crosslinker and encapsulated DHPMP in two media which were simulating pH environments in human stomach and intestines. The prolonged and controlled release of DHPMP was achieved. In vitro cytotoxic activity of PMAC-DHPMP carriers against K562 cells and the cell cycle analysis showed great potential of the carriers for application in leukemia treatment.",
journal = "Journal of Biomedical Materials Research - Part A",
title = "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment",
doi = "10.1002/jbm.a.37396"
}

Marković, M. D., Tadić, J. D., Savić, S. I., Matić, I. Z., Stanojković, T. P., Mijin, D. Ž.,& Panić, V. V.. (2022). Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A.
https://doi.org/10.1002/jbm.a.37396

Marković MD, Tadić JD, Savić SI, Matić IZ, Stanojković TP, Mijin DŽ, Panić VV. Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment. in Journal of Biomedical Materials Research - Part A. 2022;.
doi:10.1002/jbm.a.37396 .

Marković, Maja D., Tadić, Julijana D., Savić, Sanja I., Matić, Ivana Z., Stanojković, Tatjana P., Mijin, Dušan Ž., Panić, Vesna V., "Soft 3D hybrid network for delivery and controlled release of poorly soluble dihydropyrimidinone compound: An insight into the novel system for potential application in leukemia treatment" in Journal of Biomedical Materials Research - Part A (2022),
https://doi.org/10.1002/jbm.a.37396 . .

TY  - CONF
AU  - Nikolić, Nikolina
AU  - Radosavljević, Aleksandra
AU  - Spasojević, Jelena
AU  - Stamenović, Una
AU  - Vodnik, Vesna
AU  - Tadić, Julijana
AU  - Kačarević-Popović, Zorica
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12494
AB  - In this study, bi-layered hydrogel nanocomposites, based on gold nanoparticles (AuNPs) embedded in poly(N-isopropylacrylamide) (PNiPAAm) and poly(vinyl alcohol) (PVA) hydrogel were developed. PNiPAAm with AuNPs represents an active, while PVA represents a passive layer. Crosslinking of polymer matrix with stable 3D structure was obtained by the combination of freezethaw and radiolytic methods, while nanoparticles were synthesized using the seed-mediated approach. The UV-Vis absorption spectra and TEM measurements confirm the presence of spherical AuNPs, with a diameter of 30 nm. The influence of AuNPs on the swelling/deswelling behavior and on volume phase transition temperature (VPTT) in distilled water was investigated. The obtained results showed that values of network and diffusion parameters increase with the incorporation of AuNPs and that the swelling transport mechanism is a non-Fickian transport.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Proceedings
T1  - Physico-chemical characterization of Bi-layered Au-PNiPAAm/PVA hydrogel nanocomposites
VL  - 2
SP  - 371
EP  - 374
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12494
ER  - 

@conference{
author = "Nikolić, Nikolina and Radosavljević, Aleksandra and Spasojević, Jelena and Stamenović, Una and Vodnik, Vesna and Tadić, Julijana and Kačarević-Popović, Zorica",
year = "2022",
abstract = "In this study, bi-layered hydrogel nanocomposites, based on gold nanoparticles (AuNPs) embedded in poly(N-isopropylacrylamide) (PNiPAAm) and poly(vinyl alcohol) (PVA) hydrogel were developed. PNiPAAm with AuNPs represents an active, while PVA represents a passive layer. Crosslinking of polymer matrix with stable 3D structure was obtained by the combination of freezethaw and radiolytic methods, while nanoparticles were synthesized using the seed-mediated approach. The UV-Vis absorption spectra and TEM measurements confirm the presence of spherical AuNPs, with a diameter of 30 nm. The influence of AuNPs on the swelling/deswelling behavior and on volume phase transition temperature (VPTT) in distilled water was investigated. The obtained results showed that values of network and diffusion parameters increase with the incorporation of AuNPs and that the swelling transport mechanism is a non-Fickian transport.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Proceedings",
title = "Physico-chemical characterization of Bi-layered Au-PNiPAAm/PVA hydrogel nanocomposites",
volume = "2",
pages = "371-374",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12494"
}

Nikolić, N., Radosavljević, A., Spasojević, J., Stamenović, U., Vodnik, V., Tadić, J.,& Kačarević-Popović, Z.. (2022). Physico-chemical characterization of Bi-layered Au-PNiPAAm/PVA hydrogel nanocomposites. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 2, 371-374.
https://hdl.handle.net/21.15107/rcub_vinar_12494

Nikolić N, Radosavljević A, Spasojević J, Stamenović U, Vodnik V, Tadić J, Kačarević-Popović Z. Physico-chemical characterization of Bi-layered Au-PNiPAAm/PVA hydrogel nanocomposites. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Proceedings. 2022;2:371-374.
https://hdl.handle.net/21.15107/rcub_vinar_12494 .

Nikolić, Nikolina, Radosavljević, Aleksandra, Spasojević, Jelena, Stamenović, Una, Vodnik, Vesna, Tadić, Julijana, Kačarević-Popović, Zorica, "Physico-chemical characterization of Bi-layered Au-PNiPAAm/PVA hydrogel nanocomposites" in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Proceedings, 2 (2022):371-374,
https://hdl.handle.net/21.15107/rcub_vinar_12494 .

TY  - CONF
AU  - Nikolić, Nikolina
AU  - Radosavljević, Aleksandra
AU  - Spasojević, Jelena
AU  - Stamenović, Una
AU  - Tadić, Julijana
AU  - Vodnik, Vesna
AU  - Kačarević-Popović, Zorica
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12495
AB  - Recently, one of the fastest growing areas in materials sciences is the development of polymer-based smart materials, which can autonomously change their physical and/or chemical properties under external stimuli. Among them, photoactuators as smart materials that can produce a reversible mechanical deformation under light stimuli have attracted tremendous interest due to their potential applications in soft robotics, artificial muscles, and smart devices. Currently, the fabrication of photoactuators is mainly based on photothermal actuation mechanisms which include expansion/contraction, molecule sorption/desorption, and phase transition. Thermosensitive hydrogels with gold nanoparticles are probably the most commonly used active layers. The functional gold nanoparticles exhibit unique photo-thermal properties as a result of a surface plasmon resonance (SPR) electron-phonon process and intrinsic inter-band transitions. Upon immobilization in thermoresponsive hydrogel, they induce local photo-thermal shrinking under visible light irradiation and thus enable external wireless remote control of hydrogel device and programmable photo-thermomechanical motions such as bending, curling, and spiralling. In this work, bi-layered photoactuators based on thermosensitive poly(N-isopropylacrylamide) (PNiPAAm) hydrogel with incorporated gold nanoparticles as an active layer, and poly(vinyl alcohol) hydrogel as a passive layer were produced. Crosslinking of polymer matrix was done by combination of freeze-thaw and radiolytic methods, while nanoparticles were synthesized using the seed-mediated approach. Two different shapes of nanoparticles were incorporated into PNiPAAm hydrogel, gold nanospheres (AuNPs) with radius around 10 nm and gold nanorods (AuNRs) with aspect ratio of 5 (radius of 10 nm, length of 50 nm). The formation of nanoparticles within the active layer was confirmed by appearance of characteristic SPR bands with maxima around 540 nm for AuNPs, and transversal oscillation at 530 nm and longitudinal oscillation around 760 nm for AuNRs. The XRD data for both AuNPs and AuNRs are consistent with the face-centered cubic (fcc) crystal structure of bulk metallic gold, while the FTIR spectra indicated the existence of physical interaction between nanoparticles and polymer matrix. The influence of different shapes of nanoparticles on physicochemical properties of bi-layered photoactuators was investigated in order to determine swelling and deswelling properties, as well as volume phase transition temperature (VPTT). Incorporation of AuNRs into active layer of photoactuators leads to an increase of both swelling capacity and VPTT. The results obtained from compression measurements shows that mechanical properties of investigated systems depend on shape and concentration of incorporated gold nanorods. Moreover, the photo-thermo-mechanical effect induced by the visible light irradiation was visualized by bending deformation as a consequence of the energy conversion in the active layer
C3  - ICARST-2022 : Second International Conference on Applications of Radiation Science and Technology" : Book of abstracts
T1  - Bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposite photoactuators for direct optical to mechanical energy conversion
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12495
ER  - 

@conference{
author = "Nikolić, Nikolina and Radosavljević, Aleksandra and Spasojević, Jelena and Stamenović, Una and Tadić, Julijana and Vodnik, Vesna and Kačarević-Popović, Zorica",
year = "2022",
abstract = "Recently, one of the fastest growing areas in materials sciences is the development of polymer-based smart materials, which can autonomously change their physical and/or chemical properties under external stimuli. Among them, photoactuators as smart materials that can produce a reversible mechanical deformation under light stimuli have attracted tremendous interest due to their potential applications in soft robotics, artificial muscles, and smart devices. Currently, the fabrication of photoactuators is mainly based on photothermal actuation mechanisms which include expansion/contraction, molecule sorption/desorption, and phase transition. Thermosensitive hydrogels with gold nanoparticles are probably the most commonly used active layers. The functional gold nanoparticles exhibit unique photo-thermal properties as a result of a surface plasmon resonance (SPR) electron-phonon process and intrinsic inter-band transitions. Upon immobilization in thermoresponsive hydrogel, they induce local photo-thermal shrinking under visible light irradiation and thus enable external wireless remote control of hydrogel device and programmable photo-thermomechanical motions such as bending, curling, and spiralling. In this work, bi-layered photoactuators based on thermosensitive poly(N-isopropylacrylamide) (PNiPAAm) hydrogel with incorporated gold nanoparticles as an active layer, and poly(vinyl alcohol) hydrogel as a passive layer were produced. Crosslinking of polymer matrix was done by combination of freeze-thaw and radiolytic methods, while nanoparticles were synthesized using the seed-mediated approach. Two different shapes of nanoparticles were incorporated into PNiPAAm hydrogel, gold nanospheres (AuNPs) with radius around 10 nm and gold nanorods (AuNRs) with aspect ratio of 5 (radius of 10 nm, length of 50 nm). The formation of nanoparticles within the active layer was confirmed by appearance of characteristic SPR bands with maxima around 540 nm for AuNPs, and transversal oscillation at 530 nm and longitudinal oscillation around 760 nm for AuNRs. The XRD data for both AuNPs and AuNRs are consistent with the face-centered cubic (fcc) crystal structure of bulk metallic gold, while the FTIR spectra indicated the existence of physical interaction between nanoparticles and polymer matrix. The influence of different shapes of nanoparticles on physicochemical properties of bi-layered photoactuators was investigated in order to determine swelling and deswelling properties, as well as volume phase transition temperature (VPTT). Incorporation of AuNRs into active layer of photoactuators leads to an increase of both swelling capacity and VPTT. The results obtained from compression measurements shows that mechanical properties of investigated systems depend on shape and concentration of incorporated gold nanorods. Moreover, the photo-thermo-mechanical effect induced by the visible light irradiation was visualized by bending deformation as a consequence of the energy conversion in the active layer",
journal = "ICARST-2022 : Second International Conference on Applications of Radiation Science and Technology" : Book of abstracts",
title = "Bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposite photoactuators for direct optical to mechanical energy conversion",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12495"
}

Nikolić, N., Radosavljević, A., Spasojević, J., Stamenović, U., Tadić, J., Vodnik, V.,& Kačarević-Popović, Z.. (2022). Bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposite photoactuators for direct optical to mechanical energy conversion. in ICARST-2022 : Second International Conference on Applications of Radiation Science and Technology" : Book of abstracts.
https://hdl.handle.net/21.15107/rcub_vinar_12495

Nikolić N, Radosavljević A, Spasojević J, Stamenović U, Tadić J, Vodnik V, Kačarević-Popović Z. Bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposite photoactuators for direct optical to mechanical energy conversion. in ICARST-2022 : Second International Conference on Applications of Radiation Science and Technology" : Book of abstracts. 2022;.
https://hdl.handle.net/21.15107/rcub_vinar_12495 .

Nikolić, Nikolina, Radosavljević, Aleksandra, Spasojević, Jelena, Stamenović, Una, Tadić, Julijana, Vodnik, Vesna, Kačarević-Popović, Zorica, "Bi-layered Au-(PNiPAAm/PVA) hydrogel nanocomposite photoactuators for direct optical to mechanical energy conversion" in ICARST-2022 : Second International Conference on Applications of Radiation Science and Technology" : Book of abstracts (2022),
https://hdl.handle.net/21.15107/rcub_vinar_12495 .

TY  - CONF
AU  - Tadić, Julijana
AU  - Lađarević, Jelena
AU  - Marković, Maja
AU  - Ivanovska, Aleksandra
AU  - Kostić, Mirjana
AU  - Mijin, Dušan Ž.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10885
AB  - Schiff bases, or azomethine compounds, are commonly employed in the fields of organicsynthesis, metal complexes, materials, and engineering. Especially, they have gainedimportance in medicinal researches, considering their antimicrobial, anticancer, antiinflammatory, and antioxidant properties. On the other side, azo dyes are the most significantgroup of synthetic dyes, utilized in textile fiber dyeing. Conjugation of Schiff bases with azocompounds leads to the class of azo-azomethine dyes, which have numerous applicationsrelated to their coloration and biological properties. Viscose is a textile material widely used inthe medicine. Moreover, viscose fiber can be engineered in many ways which are significant inthe development of medical materials. The antioxidant effect is an important feature of medicaltextiles, such as wound dressings. In this work, the microwave-assisted synthesis andcharacterization of novel azo-azomethine dye are reported. The azo-azomethine dye is obtainedby the condensation between arylazo pyridone dye and 4-aminophenol. The structure ofsynthesized dye was determined by ATR-FTIR, NMR, and UV-Vis spectroscopy. Azoazomethine dye was used for dyeing viscose, and the washing fastness of dyed material wasevaluated according to the standard method. The viscose fabrics, before and after washing, wereanalyzed in terms of their color coordinates in the CIELab color space. The antioxidantproperties of azo-azomethine dye and dyed viscose fabrics were examined by the ABTSmethod.
PB  - Kragujevac : University of Kragujevac, Institute for Information Technologies
C3  - ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
T1  - A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties
SP  - 379
EP  - 382
DO  - 10.46793/ICCBI21.379T
ER  - 

@conference{
author = "Tadić, Julijana and Lađarević, Jelena and Marković, Maja and Ivanovska, Aleksandra and Kostić, Mirjana and Mijin, Dušan Ž.",
year = "2021",
abstract = "Schiff bases, or azomethine compounds, are commonly employed in the fields of organicsynthesis, metal complexes, materials, and engineering. Especially, they have gainedimportance in medicinal researches, considering their antimicrobial, anticancer, antiinflammatory, and antioxidant properties. On the other side, azo dyes are the most significantgroup of synthetic dyes, utilized in textile fiber dyeing. Conjugation of Schiff bases with azocompounds leads to the class of azo-azomethine dyes, which have numerous applicationsrelated to their coloration and biological properties. Viscose is a textile material widely used inthe medicine. Moreover, viscose fiber can be engineered in many ways which are significant inthe development of medical materials. The antioxidant effect is an important feature of medicaltextiles, such as wound dressings. In this work, the microwave-assisted synthesis andcharacterization of novel azo-azomethine dye are reported. The azo-azomethine dye is obtainedby the condensation between arylazo pyridone dye and 4-aminophenol. The structure ofsynthesized dye was determined by ATR-FTIR, NMR, and UV-Vis spectroscopy. Azoazomethine dye was used for dyeing viscose, and the washing fastness of dyed material wasevaluated according to the standard method. The viscose fabrics, before and after washing, wereanalyzed in terms of their color coordinates in the CIELab color space. The antioxidantproperties of azo-azomethine dye and dyed viscose fabrics were examined by the ABTSmethod.",
publisher = "Kragujevac : University of Kragujevac, Institute for Information Technologies",
journal = "ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings",
title = "A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties",
pages = "379-382",
doi = "10.46793/ICCBI21.379T"
}

Tadić, J., Lađarević, J., Marković, M., Ivanovska, A., Kostić, M.,& Mijin, D. Ž.. (2021). A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
Kragujevac : University of Kragujevac, Institute for Information Technologies., 379-382.
https://doi.org/10.46793/ICCBI21.379T

Tadić J, Lađarević J, Marković M, Ivanovska A, Kostić M, Mijin DŽ. A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings. 2021;:379-382.
doi:10.46793/ICCBI21.379T .

Tadić, Julijana, Lađarević, Jelena, Marković, Maja, Ivanovska, Aleksandra, Kostić, Mirjana, Mijin, Dušan Ž., "A Novel Azo-azomethine Dye: Synthesis, Dyeing and Antioxidant Properties" in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings (2021):379-382,
https://doi.org/10.46793/ICCBI21.379T . .

TY  - JOUR
AU  - Tadić, Julijana D.
AU  - Lađarević, Jelena M.
AU  - Vitnik, Željko J.
AU  - Vitnik, Vesna D.
AU  - Stanojković, Tatjana P.
AU  - Matić, Ivana Z.
AU  - Mijin, Dušan Ž.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10890
AB  - Seven novel azo dyes with 2-pyridone and dihydropyrimidinone moieties have been synthesized and thoroughly characterized. The azo-hydrazone tautomerism has been investigated by experimental and theoretical approaches. The optimizations of geometries have been performed with density functional theory (DFT). The vibrational and NMR spectra were calculated and correlated with experimental ones. Furthermore, quantum chemical descriptors were calculated and MEP maps were plotted to determine biological reactivity of dyes. The antioxidant assay evinced that 5, 6 and 7 are promising antioxidant candidates. In vitro cytotoxic activity was studied against three malignant cell lines: prostate adenocarcinoma (PC-3), lung carcinoma (A549) and chronic myelogenous leukemia (K562), as well as against human normal lung fibroblasts (MRC-5), using MTT assay. Examination of cytotoxic effects on human cancer cell lines showed the concentration dependent cytotoxicity of all investigated compounds. The K562 cells were the most sensitive to the cytotoxicity of the compounds 3, 5 and 6, wherein compound 5 was particularly prominent and selective in cytotoxic action between K562 (24.97 μM) and PC-3 (48.98 μM) cancer cells, and normal MRC-5 (91.11 μM) cells. Moreover, the cell cycle analysis of compound 5 was examined in K562 cells, by flow cytometry, to study its mechanism of anticancer action. Finally, in silico evaluation of physicochemical parameters, druglikeness and ADME properties showed that investigated compounds are orally bioavailable with no permeation to the blood brain barrier.
T2  - Dyes and Pigments
T1  - Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity
VL  - 187
SP  - 109123
DO  - 10.1016/j.dyepig.2020.109123
ER  - 

@article{
author = "Tadić, Julijana D. and Lađarević, Jelena M. and Vitnik, Željko J. and Vitnik, Vesna D. and Stanojković, Tatjana P. and Matić, Ivana Z. and Mijin, Dušan Ž.",
year = "2021",
abstract = "Seven novel azo dyes with 2-pyridone and dihydropyrimidinone moieties have been synthesized and thoroughly characterized. The azo-hydrazone tautomerism has been investigated by experimental and theoretical approaches. The optimizations of geometries have been performed with density functional theory (DFT). The vibrational and NMR spectra were calculated and correlated with experimental ones. Furthermore, quantum chemical descriptors were calculated and MEP maps were plotted to determine biological reactivity of dyes. The antioxidant assay evinced that 5, 6 and 7 are promising antioxidant candidates. In vitro cytotoxic activity was studied against three malignant cell lines: prostate adenocarcinoma (PC-3), lung carcinoma (A549) and chronic myelogenous leukemia (K562), as well as against human normal lung fibroblasts (MRC-5), using MTT assay. Examination of cytotoxic effects on human cancer cell lines showed the concentration dependent cytotoxicity of all investigated compounds. The K562 cells were the most sensitive to the cytotoxicity of the compounds 3, 5 and 6, wherein compound 5 was particularly prominent and selective in cytotoxic action between K562 (24.97 μM) and PC-3 (48.98 μM) cancer cells, and normal MRC-5 (91.11 μM) cells. Moreover, the cell cycle analysis of compound 5 was examined in K562 cells, by flow cytometry, to study its mechanism of anticancer action. Finally, in silico evaluation of physicochemical parameters, druglikeness and ADME properties showed that investigated compounds are orally bioavailable with no permeation to the blood brain barrier.",
journal = "Dyes and Pigments",
title = "Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity",
volume = "187",
pages = "109123",
doi = "10.1016/j.dyepig.2020.109123"
}

Tadić, J. D., Lađarević, J. M., Vitnik, Ž. J., Vitnik, V. D., Stanojković, T. P., Matić, I. Z.,& Mijin, D. Ž.. (2021). Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity. in Dyes and Pigments, 187, 109123.
https://doi.org/10.1016/j.dyepig.2020.109123

Tadić JD, Lađarević JM, Vitnik ŽJ, Vitnik VD, Stanojković TP, Matić IZ, Mijin DŽ. Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity. in Dyes and Pigments. 2021;187:109123.
doi:10.1016/j.dyepig.2020.109123 .

Tadić, Julijana D., Lađarević, Jelena M., Vitnik, Željko J., Vitnik, Vesna D., Stanojković, Tatjana P., Matić, Ivana Z., Mijin, Dušan Ž., "Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity" in Dyes and Pigments, 187 (2021):109123,
https://doi.org/10.1016/j.dyepig.2020.109123 . .

TY  - CONF
AU  - Porobić, Slavica
AU  - Lađarević, Jelena
AU  - Kojić, Marija
AU  - Katnić, Đurica
AU  - Marinović-Cincović, Milena
AU  - Tadić, Julijana
AU  - Mijin, Dušan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11426
AB  - A new heterocyclic azo dye 5-(2,6-dimethylphenyl)-6-hydroxy-4-methyl-2-oxo-1,2- dihydropyridine-3-carboxamide was synthesized and structurally characterized by elemental analysis, FTIR, 1H and 13C NMR spectroscopy techniques. These analysis have confirmed that synthesized dye exists in the tinctorial strongest tautomeric form, hydrazone form. The dye is characterized by reflection spectrum, while absorption and emisson spectra are recorded in nine different solvents. The antioxidant activity of the synthesized dye has been chemically tested and has been shown to have great potential as an antioxidant molecule.
PB  - Szeged : University of Szeged
C3  - 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
T1  - Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
SP  - 281
EP  - 285
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11426
ER  - 

@conference{
author = "Porobić, Slavica and Lađarević, Jelena and Kojić, Marija and Katnić, Đurica and Marinović-Cincović, Milena and Tadić, Julijana and Mijin, Dušan",
year = "2021",
abstract = "A new heterocyclic azo dye 5-(2,6-dimethylphenyl)-6-hydroxy-4-methyl-2-oxo-1,2- dihydropyridine-3-carboxamide was synthesized and structurally characterized by elemental analysis, FTIR, 1H and 13C NMR spectroscopy techniques. These analysis have confirmed that synthesized dye exists in the tinctorial strongest tautomeric form, hydrazone form. The dye is characterized by reflection spectrum, while absorption and emisson spectra are recorded in nine different solvents. The antioxidant activity of the synthesized dye has been chemically tested and has been shown to have great potential as an antioxidant molecule.",
publisher = "Szeged : University of Szeged",
journal = "27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary",
title = "Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide",
pages = "281-285",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11426"
}

Porobić, S., Lađarević, J., Kojić, M., Katnić, Đ., Marinović-Cincović, M., Tadić, J.,& Mijin, D.. (2021). Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
Szeged : University of Szeged., 281-285.
https://hdl.handle.net/21.15107/rcub_vinar_11426

Porobić S, Lađarević J, Kojić M, Katnić Đ, Marinović-Cincović M, Tadić J, Mijin D. Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary. 2021;:281-285.
https://hdl.handle.net/21.15107/rcub_vinar_11426 .

Porobić, Slavica, Lađarević, Jelena, Kojić, Marija, Katnić, Đurica, Marinović-Cincović, Milena, Tadić, Julijana, Mijin, Dušan, "Optical and Antioxidative Properties of 5-(2,6-dimethylphenyl)- 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide" in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary (2021):281-285,
https://hdl.handle.net/21.15107/rcub_vinar_11426 .

TY  - CONF
AU  - Tadić, Julijana
AU  - Janković, Nenad
AU  - Lađarević, Jelena
AU  - Porobić, Slavica
AU  - Kojić, Marija
AU  - Marinović-Cincović, Milena
AU  - Mijin, Dušan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11428
AB  - Molecular imaging is a relatively new research field, which has demonstrated great potential, especially in clinical oncology – from drug development to cancer early detection. The key of fluorescence imaging is the construction of fluorescent probe which is composed of two parts, the recognition groups to recognize cancer cells, and fluorophores to signal the recognition events. In this research, the structure of new fluorescent azo dye based on 2-oxo-1,2,3,4-tetrahydropyrimidin and 2-pyridone moieties has been reported. The absorption and emission properties of the investigated azo dye have been studied using UV-Vis and fluorescence spectroscopy. The obtained results suggest that studied dye meets the requirements for new green-emitting fluorescent probe, suitable for further application in biomedical researches.
PB  - Szeged : University of Szeged
C3  - 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
T1  - 2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe
SP  - 324
EP  - 326
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11428
ER  - 

@conference{
author = "Tadić, Julijana and Janković, Nenad and Lađarević, Jelena and Porobić, Slavica and Kojić, Marija and Marinović-Cincović, Milena and Mijin, Dušan",
year = "2021",
abstract = "Molecular imaging is a relatively new research field, which has demonstrated great potential, especially in clinical oncology – from drug development to cancer early detection. The key of fluorescence imaging is the construction of fluorescent probe which is composed of two parts, the recognition groups to recognize cancer cells, and fluorophores to signal the recognition events. In this research, the structure of new fluorescent azo dye based on 2-oxo-1,2,3,4-tetrahydropyrimidin and 2-pyridone moieties has been reported. The absorption and emission properties of the investigated azo dye have been studied using UV-Vis and fluorescence spectroscopy. The obtained results suggest that studied dye meets the requirements for new green-emitting fluorescent probe, suitable for further application in biomedical researches.",
publisher = "Szeged : University of Szeged",
journal = "27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary",
title = "2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe",
pages = "324-326",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11428"
}

Tadić, J., Janković, N., Lađarević, J., Porobić, S., Kojić, M., Marinović-Cincović, M.,& Mijin, D.. (2021). 2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
Szeged : University of Szeged., 324-326.
https://hdl.handle.net/21.15107/rcub_vinar_11428

Tadić J, Janković N, Lađarević J, Porobić S, Kojić M, Marinović-Cincović M, Mijin D. 2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary. 2021;:324-326.
https://hdl.handle.net/21.15107/rcub_vinar_11428 .

Tadić, Julijana, Janković, Nenad, Lađarević, Jelena, Porobić, Slavica, Kojić, Marija, Marinović-Cincović, Milena, Mijin, Dušan, "2-oxo-1,2,3,4-tetrahydropyrimidine-azo-pyridone Dye: A Potential Application as New Green-Emitting Fluorescent Probe" in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary (2021):324-326,
https://hdl.handle.net/21.15107/rcub_vinar_11428 .

TY  - CONF
AU  - Katnić, Đurica
AU  - Kojić, Marija
AU  - Tadić, Julijana
AU  - Vasiljević, Bojana
AU  - Marinović-Cincović, Milena
AU  - Krstić, Aleksandar
AU  - Porobić, Slavica
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11420
AB  - Removal of heavy metals is important because of their toxic effects on living organisms and unwanted anthropogenic effects. Biochar is suitable as an adsorbent of heavy metals due to its advantages such as various sources of biomass, a large number of microporous channels and surface functional groups, as well as due to its economic viability. There is no data about the plum pomace biochar usage as adsorbent for lead removal. In this study, the plum pomace biochar modified with gamma irradiation (IrPP) is used for the removal of Pb2+ ions from the aqueous solution. The SEM micrographs revealed that surface morphology of plum pomace is suitable for metal adsorption. The results of adsorption kinetics demonstrated that the removal process of Pb2+ ions onto IrPP follows a pseudo-second kinetic model, which is confirmed by a better agreement between qe,cal=227 mg g–1 and qe,exp=224 mg g–1. Therefore, based on preliminary research, it can be concluded that IrPP originating from biowaste is a promising, eco-friendly sorbent of heavy metal from wastewater.
PB  - Szeged : University of Szeged
C3  - 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
T1  - Adsorption of Pb2+ Ions on Gamma Irradiated Plum Pomace Biochar
SP  - 155
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11420
ER  - 

@conference{
author = "Katnić, Đurica and Kojić, Marija and Tadić, Julijana and Vasiljević, Bojana and Marinović-Cincović, Milena and Krstić, Aleksandar and Porobić, Slavica",
year = "2021",
abstract = "Removal of heavy metals is important because of their toxic effects on living organisms and unwanted anthropogenic effects. Biochar is suitable as an adsorbent of heavy metals due to its advantages such as various sources of biomass, a large number of microporous channels and surface functional groups, as well as due to its economic viability. There is no data about the plum pomace biochar usage as adsorbent for lead removal. In this study, the plum pomace biochar modified with gamma irradiation (IrPP) is used for the removal of Pb2+ ions from the aqueous solution. The SEM micrographs revealed that surface morphology of plum pomace is suitable for metal adsorption. The results of adsorption kinetics demonstrated that the removal process of Pb2+ ions onto IrPP follows a pseudo-second kinetic model, which is confirmed by a better agreement between qe,cal=227 mg g–1 and qe,exp=224 mg g–1. Therefore, based on preliminary research, it can be concluded that IrPP originating from biowaste is a promising, eco-friendly sorbent of heavy metal from wastewater.",
publisher = "Szeged : University of Szeged",
journal = "27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary",
title = "Adsorption of Pb2+ Ions on Gamma Irradiated Plum Pomace Biochar",
pages = "155-158",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11420"
}

Katnić, Đ., Kojić, M., Tadić, J., Vasiljević, B., Marinović-Cincović, M., Krstić, A.,& Porobić, S.. (2021). Adsorption of Pb2+ Ions on Gamma Irradiated Plum Pomace Biochar. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
Szeged : University of Szeged., 155-158.
https://hdl.handle.net/21.15107/rcub_vinar_11420

Katnić Đ, Kojić M, Tadić J, Vasiljević B, Marinović-Cincović M, Krstić A, Porobić S. Adsorption of Pb2+ Ions on Gamma Irradiated Plum Pomace Biochar. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary. 2021;:155-158.
https://hdl.handle.net/21.15107/rcub_vinar_11420 .

Katnić, Đurica, Kojić, Marija, Tadić, Julijana, Vasiljević, Bojana, Marinović-Cincović, Milena, Krstić, Aleksandar, Porobić, Slavica, "Adsorption of Pb2+ Ions on Gamma Irradiated Plum Pomace Biochar" in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary (2021):155-158,
https://hdl.handle.net/21.15107/rcub_vinar_11420 .

TY  - CONF
AU  - Kojić, Marija
AU  - Porobić, Slavica
AU  - Katnić, Đurica
AU  - Tadić, Julijana
AU  - Vasiljević, Bojana
AU  - Ožegović, Milica
AU  - Marinović-Cincović, Milena
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11422
AB  - A carbon-rich product, hydrochar, was synthesized by hydrothermal carbonization (HTC) of spent mushroom substrate (SMS), at temperature of 260 °C. The thermal kinetic analysis has shown that hydrothermally treatment improve the combustion behavior of hydrochar. The kinetic parameters were determined by Kissinger and Ozawa methods. The SMS-260 had a significantly lower activation energy compared to the SMS, which means that this hydrochar needs a smaller amount of energy to start combustion. Generally, the preliminary results show that HTC is an effective way to transform SMS into alternative solid biofuel.
PB  - Szeged : University of Szeged
C3  - 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
T1  - Thermal Kinetic Analysis of the Spent Mushroom Substrate and Hydrochar
SP  - 168
EP  - 170
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11422
ER  - 

@conference{
author = "Kojić, Marija and Porobić, Slavica and Katnić, Đurica and Tadić, Julijana and Vasiljević, Bojana and Ožegović, Milica and Marinović-Cincović, Milena",
year = "2021",
abstract = "A carbon-rich product, hydrochar, was synthesized by hydrothermal carbonization (HTC) of spent mushroom substrate (SMS), at temperature of 260 °C. The thermal kinetic analysis has shown that hydrothermally treatment improve the combustion behavior of hydrochar. The kinetic parameters were determined by Kissinger and Ozawa methods. The SMS-260 had a significantly lower activation energy compared to the SMS, which means that this hydrochar needs a smaller amount of energy to start combustion. Generally, the preliminary results show that HTC is an effective way to transform SMS into alternative solid biofuel.",
publisher = "Szeged : University of Szeged",
journal = "27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary",
title = "Thermal Kinetic Analysis of the Spent Mushroom Substrate and Hydrochar",
pages = "168-170",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11422"
}

Kojić, M., Porobić, S., Katnić, Đ., Tadić, J., Vasiljević, B., Ožegović, M.,& Marinović-Cincović, M.. (2021). Thermal Kinetic Analysis of the Spent Mushroom Substrate and Hydrochar. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary
Szeged : University of Szeged., 168-170.
https://hdl.handle.net/21.15107/rcub_vinar_11422

Kojić M, Porobić S, Katnić Đ, Tadić J, Vasiljević B, Ožegović M, Marinović-Cincović M. Thermal Kinetic Analysis of the Spent Mushroom Substrate and Hydrochar. in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary. 2021;:168-170.
https://hdl.handle.net/21.15107/rcub_vinar_11422 .

Kojić, Marija, Porobić, Slavica, Katnić, Đurica, Tadić, Julijana, Vasiljević, Bojana, Ožegović, Milica, Marinović-Cincović, Milena, "Thermal Kinetic Analysis of the Spent Mushroom Substrate and Hydrochar" in 27th International Symposium on Analytical and Environmental Problems : Proceedings; November 22-23, 2021; Szeged, Hungary (2021):168-170,
https://hdl.handle.net/21.15107/rcub_vinar_11422 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Panić, Vesna V.
AU  - Tadić, Julijana D.
AU  - Pjanović, Rada V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10884
AB  - Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.
PB  - Kragujevac : University of Kragujevac, Institute for Information Technologies
C3  - ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
T1  - Effect of crosslinker amount on hybrid hydrogels swelling and drug release
SP  - 125
EP  - 128
DO  - 10.46793/ICCBI21.125M
ER  - 

@conference{
author = "Marković, Maja D. and Panić, Vesna V. and Tadić, Julijana D. and Pjanović, Rada V.",
year = "2021",
abstract = "Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.",
publisher = "Kragujevac : University of Kragujevac, Institute for Information Technologies",
journal = "ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings",
title = "Effect of crosslinker amount on hybrid hydrogels swelling and drug release",
pages = "125-128",
doi = "10.46793/ICCBI21.125M"
}

Marković, M. D., Panić, V. V., Tadić, J. D.,& Pjanović, R. V.. (2021). Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings
Kragujevac : University of Kragujevac, Institute for Information Technologies., 125-128.
https://doi.org/10.46793/ICCBI21.125M

Marković MD, Panić VV, Tadić JD, Pjanović RV. Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings. 2021;:125-128.
doi:10.46793/ICCBI21.125M .

Marković, Maja D., Panić, Vesna V., Tadić, Julijana D., Pjanović, Rada V., "Effect of crosslinker amount on hybrid hydrogels swelling and drug release" in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings (2021):125-128,
https://doi.org/10.46793/ICCBI21.125M . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Tadić, Julijana
AU  - Pjanović, Rada V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11423
AB  - Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.
PB  - University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary
C3  - The 27 th International Symposium on Analytical and Environmental Problems
T1  - Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount
SP  - 203
EP  - 207
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11423
ER  - 

@conference{
author = "Marković, Maja D. and Tadić, Julijana and Pjanović, Rada V.",
year = "2021",
abstract = "Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.",
publisher = "University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary",
journal = "The 27 th International Symposium on Analytical and Environmental Problems",
title = "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount",
pages = "203-207",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11423"
}

Marković, M. D., Tadić, J.,& Pjanović, R. V.. (2021). Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems
University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary., 203-207.
https://hdl.handle.net/21.15107/rcub_vinar_11423

Marković MD, Tadić J, Pjanović RV. Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems. 2021;:203-207.
https://hdl.handle.net/21.15107/rcub_vinar_11423 .

Marković, Maja D., Tadić, Julijana, Pjanović, Rada V., "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount" in The 27 th International Symposium on Analytical and Environmental Problems (2021):203-207,
https://hdl.handle.net/21.15107/rcub_vinar_11423 .

TY  - JOUR
AU  - Tadić, Julijana D.
AU  - Mihajlović, Marina
AU  - Jovanović, Mica
AU  - Mijin, Dušan Ž.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10891
AB  - In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.
T2  - Journal of the Serbian Chemical Society
T1  - Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones
VL  - 84
IS  - 6
SP  - 531
EP  - 538
DO  - 10.2298/JSC180703092T
ER  - 

@article{
author = "Tadić, Julijana D. and Mihajlović, Marina and Jovanović, Mica and Mijin, Dušan Ž.",
year = "2019",
abstract = "In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2-pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, H-1-NMR and UV-Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production.",
journal = "Journal of the Serbian Chemical Society",
title = "Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones",
volume = "84",
number = "6",
pages = "531-538",
doi = "10.2298/JSC180703092T"
}

Tadić, J. D., Mihajlović, M., Jovanović, M.,& Mijin, D. Ž.. (2019). Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones. in Journal of the Serbian Chemical Society, 84(6), 531-538.
https://doi.org/10.2298/JSC180703092T

Tadić JD, Mihajlović M, Jovanović M, Mijin DŽ. Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones. in Journal of the Serbian Chemical Society. 2019;84(6):531-538.
doi:10.2298/JSC180703092T .

Tadić, Julijana D., Mihajlović, Marina, Jovanović, Mica, Mijin, Dušan Ž., "Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones" in Journal of the Serbian Chemical Society, 84, no. 6 (2019):531-538,
https://doi.org/10.2298/JSC180703092T . .

TY  - JOUR
AU  - Bundaleski, Nenad
AU  - Radisavljević, Ivana
AU  - Ivanović, Nenad
AU  - Rakočević, Zlatko Lj.
AU  - Medić-Ilić, Mirjana
AU  - Tadić, Julijana D.
AU  - Teodoro, Orlando M. N. D.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0039602818307611
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7977
AB  - Local structural and electronic properties around Fe in multi-component Cd0.99Fe0.01Te0.97S0.03 system were studied by means of X-ray absorption fine structure (XAFS). Composition of non-polar (110) surfaces of Cd0.97Fe0.03Te and Cd0.99Fe0.01Te0.97S0.03 systems and mechanism of their oxidation in ambient conditions were studied by Atomic Force Microscopy (AFM) and X-ray Photoelectron Spectroscopy (XPS). It has been found that Fe preferentially substitutes Cd, but due to much smaller covalent radius and preferences for paring with S, it causes local distortion of the host CdTe lattice. The distortion is confined to the Fe-immediate surrounding and the second and third coordination shell atoms are (inside experimental uncertainties) placed at distances expected in CdTe. Although local structure around Fe is well defined in the bulk of both samples, their near-surface region is completely depleted from Fe, and in case of Cd0.99Fe0.01Te0.97S0.03 somewhat enriched in S. Special attention is, therefore, paid to characterization of the near-surface region and evaluation of its composition and structure. To that end we have introduced a general standard-free algorithm for XPS data analysis of the two-layer surface structure (bulk, oxide layer, and the impurity layer). Results of the in-depth composition analysis revealed that despite different bulk composition and impurity layer thickness, underneath the topmost impurity layer lays approximately one monolayer of CdTeO3 which passivates the surface. © 2018 Elsevier B.V.
T2  - Surface Science
T1  - Local, electronic and surface structure of multi-component Fe-doped CdTe(S) systems
VL  - 681
SP  - 76
EP  - 86
DO  - 10.1016/j.susc.2018.11.007
ER  - 

@article{
author = "Bundaleski, Nenad and Radisavljević, Ivana and Ivanović, Nenad and Rakočević, Zlatko Lj. and Medić-Ilić, Mirjana and Tadić, Julijana D. and Teodoro, Orlando M. N. D.",
year = "2019",
abstract = "Local structural and electronic properties around Fe in multi-component Cd0.99Fe0.01Te0.97S0.03 system were studied by means of X-ray absorption fine structure (XAFS). Composition of non-polar (110) surfaces of Cd0.97Fe0.03Te and Cd0.99Fe0.01Te0.97S0.03 systems and mechanism of their oxidation in ambient conditions were studied by Atomic Force Microscopy (AFM) and X-ray Photoelectron Spectroscopy (XPS). It has been found that Fe preferentially substitutes Cd, but due to much smaller covalent radius and preferences for paring with S, it causes local distortion of the host CdTe lattice. The distortion is confined to the Fe-immediate surrounding and the second and third coordination shell atoms are (inside experimental uncertainties) placed at distances expected in CdTe. Although local structure around Fe is well defined in the bulk of both samples, their near-surface region is completely depleted from Fe, and in case of Cd0.99Fe0.01Te0.97S0.03 somewhat enriched in S. Special attention is, therefore, paid to characterization of the near-surface region and evaluation of its composition and structure. To that end we have introduced a general standard-free algorithm for XPS data analysis of the two-layer surface structure (bulk, oxide layer, and the impurity layer). Results of the in-depth composition analysis revealed that despite different bulk composition and impurity layer thickness, underneath the topmost impurity layer lays approximately one monolayer of CdTeO3 which passivates the surface. © 2018 Elsevier B.V.",
journal = "Surface Science",
title = "Local, electronic and surface structure of multi-component Fe-doped CdTe(S) systems",
volume = "681",
pages = "76-86",
doi = "10.1016/j.susc.2018.11.007"
}

Bundaleski, N., Radisavljević, I., Ivanović, N., Rakočević, Z. Lj., Medić-Ilić, M., Tadić, J. D.,& Teodoro, O. M. N. D.. (2019). Local, electronic and surface structure of multi-component Fe-doped CdTe(S) systems. in Surface Science, 681, 76-86.
https://doi.org/10.1016/j.susc.2018.11.007

Bundaleski N, Radisavljević I, Ivanović N, Rakočević ZL, Medić-Ilić M, Tadić JD, Teodoro OMND. Local, electronic and surface structure of multi-component Fe-doped CdTe(S) systems. in Surface Science. 2019;681:76-86.
doi:10.1016/j.susc.2018.11.007 .

Bundaleski, Nenad, Radisavljević, Ivana, Ivanović, Nenad, Rakočević, Zlatko Lj., Medić-Ilić, Mirjana, Tadić, Julijana D., Teodoro, Orlando M. N. D., "Local, electronic and surface structure of multi-component Fe-doped CdTe(S) systems" in Surface Science, 681 (2019):76-86,
https://doi.org/10.1016/j.susc.2018.11.007 . .