Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount
Конференцијски прилог (Објављена верзија)
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Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzeh...ow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.
Извор:
The 27 th International Symposium on Analytical and Environmental Problems, 2021, 203-207Издавач:
- University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Колекције
Институција/група
VinčaTY - CONF AU - Marković, Maja D. AU - Tadić, Julijana AU - Pjanović, Rada V. PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11423 AB - Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy. PB - University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary C3 - The 27 th International Symposium on Analytical and Environmental Problems T1 - Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount SP - 203 EP - 207 UR - https://hdl.handle.net/21.15107/rcub_vinar_11423 ER -
@conference{ author = "Marković, Maja D. and Tadić, Julijana and Pjanović, Rada V.", year = "2021", abstract = "Nowadays, humanity are faced with many challenges which affect health of people all aroundthe globe (such as climate change, new diseases and/or already present ones for which cure hasnot been found yet – cancer). The efforts of researchers on the field of drug delivery systemsbring everyday novel tools for safer and more effective therapy. pH sensitive hydrogels basedon poly(methacrylic acid) are recognized as materials with huge potential for controlled releaseof drugs. The encapsulation and controlled release of many chemotherapeutics is quitechallenge due to their poorly water-solubility. In our previous research we overcome thisproblem by modifying hydrophilic pol(methacrylic acid) with amphiphilic casein and showedthat prepared material have potential for encapsulation and controlled release of poorly watersoluble model drug – caffeine (PMAC carriers). In present study we deepened further ourresearch and employed various models: Ritger-Peppas, Higuchi and Kopcha model to analyzehow the change of crosslinker amount affect the mechanism of release kinetics of caffeine inmedium with pH of 6.8 (which simulated the environment in human intestines). Obtainedresults showed that only by changing one parameter such as crosslinker amount it is possible tofine tune the type of drug release mechanism, due to which the PMAC carriers would be ableto respond to the specific demands of therapy.", publisher = "University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary", journal = "The 27 th International Symposium on Analytical and Environmental Problems", title = "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount", pages = "203-207", url = "https://hdl.handle.net/21.15107/rcub_vinar_11423" }
Marković, M. D., Tadić, J.,& Pjanović, R. V.. (2021). Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems University of Szeged, H-6720 Szeged, Dugonics tér 13, Hungary., 203-207. https://hdl.handle.net/21.15107/rcub_vinar_11423
Marković MD, Tadić J, Pjanović RV. Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount. in The 27 th International Symposium on Analytical and Environmental Problems. 2021;:203-207. https://hdl.handle.net/21.15107/rcub_vinar_11423 .
Marković, Maja D., Tadić, Julijana, Pjanović, Rada V., "Analysis of kinetics of poorly water-soluble drug release from hydrogels based on poly(methacrylic acid) and casein with different crosslinker amount" in The 27 th International Symposium on Analytical and Environmental Problems (2021):203-207, https://hdl.handle.net/21.15107/rcub_vinar_11423 .