Effect of crosslinker amount on hybrid hydrogels swelling and drug release
Апстракт
Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – ...was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.
Кључне речи:
poly(methacrylic acid) / casein / crosslinking / hydrogels swelling / drug releaseИзвор:
ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings, 2021, 125-128Издавач:
- Kragujevac : University of Kragujevac, Institute for Information Technologies
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Колекције
Институција/група
VinčaTY - CONF AU - Marković, Maja D. AU - Panić, Vesna V. AU - Tadić, Julijana D. AU - Pjanović, Rada V. PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10884 AB - Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances. PB - Kragujevac : University of Kragujevac, Institute for Information Technologies C3 - ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings T1 - Effect of crosslinker amount on hybrid hydrogels swelling and drug release SP - 125 EP - 128 DO - 10.46793/ICCBI21.125M ER -
@conference{ author = "Marković, Maja D. and Panić, Vesna V. and Tadić, Julijana D. and Pjanović, Rada V.", year = "2021", abstract = "Targeted drug delivery is powerful tool which researchers use to achieve safer and more efficienttherapy of many diseases, including various types of cancer. Many chemotherapeutics are poorly watersoluble, so their encapsulation and targeted delivery remain quite challenge. Hydrogels based onpoly(methacrylic acid) (PMAA) are widely investigated for targeted drug delivery due to their pHsensitivity, non-toxicity and biocompatibility. Still, due to the PMAA highly hydrophilic nature, PMAAcan only be used for encapsulation and targeted delivery of water-soluble drugs. Our previous researchwas directed towards overcoming this limitation: PMAA was modified with amphiphilic protein –casein and poorly-water soluble model drug – caffeine – was encapsulated (PMAC). Present study isfocused on investigation how variation of amount of one of the most important hydrogels networkparameter such as crosslinker affect PMAC swelling properties and caffeine release. The group ofhybrid hydrogels – PMAC – was synthesized with various amount of crosslinker: 0.4mol%, 0.8mol%,1.6mol% and 3.2mol% with respect to methacrylic acid. Swelling behavior of hybrid hydrogels andcaffeine release was investigated in two environments which simulated human stomach and intestines.Obtained results showed that targeted delivery of poorly water-soluble model drug was achieved andthat its release can be prolonged up to 24h. Also, kinetic of poorly water-soluble drug release can beeasily modified only by changing crosslinker amount. PMAC hybrid hydrogels have huge potential fortargeted delivery of poorly water-soluble active substances.", publisher = "Kragujevac : University of Kragujevac, Institute for Information Technologies", journal = "ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings", title = "Effect of crosslinker amount on hybrid hydrogels swelling and drug release", pages = "125-128", doi = "10.46793/ICCBI21.125M" }
Marković, M. D., Panić, V. V., Tadić, J. D.,& Pjanović, R. V.. (2021). Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings Kragujevac : University of Kragujevac, Institute for Information Technologies., 125-128. https://doi.org/10.46793/ICCBI21.125M
Marković MD, Panić VV, Tadić JD, Pjanović RV. Effect of crosslinker amount on hybrid hydrogels swelling and drug release. in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings. 2021;:125-128. doi:10.46793/ICCBI21.125M .
Marković, Maja D., Panić, Vesna V., Tadić, Julijana D., Pjanović, Rada V., "Effect of crosslinker amount on hybrid hydrogels swelling and drug release" in ICCBIKG 2021 : 1st International Conference on Chemo and BioInformatics : Book of Proceedings (2021):125-128, https://doi.org/10.46793/ICCBI21.125M . .