TY  - JOUR
AU  - Sevaljevic, L
AU  - Dobric, S
AU  - Bogojevic, D
AU  - Petrović, M
AU  - Korićanac, Goran
AU  - Vulović, Mojca D.
AU  - Kanazir, DA
AU  - Ribarac-Stepić, Nevena B.
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2645
AB  - This work was aimed at the radioprotective efficacy of turpentine oil (TO), alpha(2)-Macroglobulin (alpha(2)-M), Amifostine (Ami) and/or dexamethasone (Dex). These agents were administrated, alone or in combination, prior to irradiation of rats with 6.7 Gy (LD50/30). The survival was recorded daily for 4 weeks after irradiation and body weight, peripheral leukocytes and thrombocytes were measured. The plasma concentration of alpha(2)-M and other acute phase proteins were determined by crossed immunoelectrophoresis. All rats receiving alpha(2)-M and Ami alone or in combination survived the radiation injury, whereas the rate of survival of TO-treated rats was 90%. Radiation and therapy-induced changes in the expression of acute phase protein genes were atypical for the acute phase reaction. Dex alone was lethal for 45% and 55% of control and irradiated rats, respectively. Pretreatment with 1mg Dex reduced radioprotective efficacy of TO and Ami to 30% and 40%, respectively. Given together TO and Ami provided 70% protection to rats receiving Dex. The TO and GYM enhanced the rate of survival from 50% to 90% and 100%, respectively. In the presence of 1 mg Dex the TO-induced radioprotectors and Ami exhibited radiosensitizing rather than radioprotecting activities.
T2  - Journal of Radiation Research
T1  - The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation
VL  - 44
IS  - 1
SP  - 59
EP  - 67
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2645
ER  - 

@article{
author = "Sevaljevic, L and Dobric, S and Bogojevic, D and Petrović, M and Korićanac, Goran and Vulović, Mojca D. and Kanazir, DA and Ribarac-Stepić, Nevena B.",
year = "2003",
abstract = "This work was aimed at the radioprotective efficacy of turpentine oil (TO), alpha(2)-Macroglobulin (alpha(2)-M), Amifostine (Ami) and/or dexamethasone (Dex). These agents were administrated, alone or in combination, prior to irradiation of rats with 6.7 Gy (LD50/30). The survival was recorded daily for 4 weeks after irradiation and body weight, peripheral leukocytes and thrombocytes were measured. The plasma concentration of alpha(2)-M and other acute phase proteins were determined by crossed immunoelectrophoresis. All rats receiving alpha(2)-M and Ami alone or in combination survived the radiation injury, whereas the rate of survival of TO-treated rats was 90%. Radiation and therapy-induced changes in the expression of acute phase protein genes were atypical for the acute phase reaction. Dex alone was lethal for 45% and 55% of control and irradiated rats, respectively. Pretreatment with 1mg Dex reduced radioprotective efficacy of TO and Ami to 30% and 40%, respectively. Given together TO and Ami provided 70% protection to rats receiving Dex. The TO and GYM enhanced the rate of survival from 50% to 90% and 100%, respectively. In the presence of 1 mg Dex the TO-induced radioprotectors and Ami exhibited radiosensitizing rather than radioprotecting activities.",
journal = "Journal of Radiation Research",
title = "The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation",
volume = "44",
number = "1",
pages = "59-67",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2645"
}

Sevaljevic, L., Dobric, S., Bogojevic, D., Petrović, M., Korićanac, G., Vulović, M. D., Kanazir, D.,& Ribarac-Stepić, N. B.. (2003). The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation. in Journal of Radiation Research, 44(1), 59-67.
https://hdl.handle.net/21.15107/rcub_vinar_2645

Sevaljevic L, Dobric S, Bogojevic D, Petrović M, Korićanac G, Vulović MD, Kanazir D, Ribarac-Stepić NB. The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation. in Journal of Radiation Research. 2003;44(1):59-67.
https://hdl.handle.net/21.15107/rcub_vinar_2645 .

Sevaljevic, L, Dobric, S, Bogojevic, D, Petrović, M, Korićanac, Goran, Vulović, Mojca D., Kanazir, DA, Ribarac-Stepić, Nevena B., "The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation" in Journal of Radiation Research, 44, no. 1 (2003):59-67,
https://hdl.handle.net/21.15107/rcub_vinar_2645 .

TY  - JOUR
AU  - Sevaljevic, L
AU  - Isenović, Esma R.
AU  - Vulović, Mojca D.
AU  - Mačvanin, Mirjana
AU  - Žakula, Zorica
AU  - Kanazir, Dušan T.
AU  - Ribarac-Stepić, Nevena B.
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2450
AB  - The responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR binding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes.
T2  - Biological Signals and Receptors
T1  - The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines
VL  - 10
IS  - 5
SP  - 299
EP  - 309
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2450
ER  - 

@article{
author = "Sevaljevic, L and Isenović, Esma R. and Vulović, Mojca D. and Mačvanin, Mirjana and Žakula, Zorica and Kanazir, Dušan T. and Ribarac-Stepić, Nevena B.",
year = "2001",
abstract = "The responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR binding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes.",
journal = "Biological Signals and Receptors",
title = "The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines",
volume = "10",
number = "5",
pages = "299-309",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2450"
}

Sevaljevic, L., Isenović, E. R., Vulović, M. D., Mačvanin, M., Žakula, Z., Kanazir, D. T.,& Ribarac-Stepić, N. B.. (2001). The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines. in Biological Signals and Receptors, 10(5), 299-309.
https://hdl.handle.net/21.15107/rcub_vinar_2450

Sevaljevic L, Isenović ER, Vulović MD, Mačvanin M, Žakula Z, Kanazir DT, Ribarac-Stepić NB. The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines. in Biological Signals and Receptors. 2001;10(5):299-309.
https://hdl.handle.net/21.15107/rcub_vinar_2450 .

Sevaljevic, L, Isenović, Esma R., Vulović, Mojca D., Mačvanin, Mirjana, Žakula, Zorica, Kanazir, Dušan T., Ribarac-Stepić, Nevena B., "The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines" in Biological Signals and Receptors, 10, no. 5 (2001):299-309,
https://hdl.handle.net/21.15107/rcub_vinar_2450 .

TY  - JOUR
AU  - Sevaljevic, L
AU  - Mačvanin, Mirjana
AU  - Žakula, Zorica
AU  - Kanazir, Dušan T.
AU  - Ribarac-Stepić, Nevena B.
PY  - 1998
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2189
AB  - Hormonal requirements for full hepatic expression of alpha(2)-macroglobulin (alpha(2)M), alpha(1)-acid glycoprotein (AGP), haptoglobin (Hp) and gamma-fibrinogen (Fb) were assessed at the level of mRNA. Prior to exposure to turpentine-induced inflammation, rats were either depleted of glucocorticoids by adrenalectomy or supplemented with an excess of dexamethasone. Adrenalectomy alone did not affect the basal level of acute phase protein (APP) expression except for alpha(2)M mRNA, the level of which was enhanced. In contrast, dexamethasone treatment alone promoted full induction of alpha(2)M, significant, but not maximal increase of AGP and Hp mRNAs and suppression of Fb. In adrenalectomized rats, acute phase (AP)-cytokines, released in response to inflammation, promoted full expression of Fb and Hp and increased the level of AGP mRNA whereas alpha(2)M mRNA remained at the basal level. Inflammation in dexamethasone pretreated rats elicited changes which, in comparison to mRNA values for dexamethasone unpretreated inflamed rats, were seen as overexpression of alpha(2)M, full expression of AGP and incomplete expression of Hp, whereas Fb mRNA remained at the basal level. These data suggest that glucocorticoids are the principal inducers of a(2)M and AP-cytokines of Fb. For full induction of AGP, additive actions of glucocorticoids and AP-cytokines are required whereas expression of Hp is predominantly controlled by AP-cytokines. (C) 1998 Elsevier Science Ltd. All rights reserved.
T2  - Journal of Steroid Biochemistry and Molecular Biology
T1  - Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver
VL  - 66
IS  - 5-6
SP  - 347
EP  - 353
DO  - 10.1016/S0960-0760(98)00060-0
ER  - 

@article{
author = "Sevaljevic, L and Mačvanin, Mirjana and Žakula, Zorica and Kanazir, Dušan T. and Ribarac-Stepić, Nevena B.",
year = "1998",
abstract = "Hormonal requirements for full hepatic expression of alpha(2)-macroglobulin (alpha(2)M), alpha(1)-acid glycoprotein (AGP), haptoglobin (Hp) and gamma-fibrinogen (Fb) were assessed at the level of mRNA. Prior to exposure to turpentine-induced inflammation, rats were either depleted of glucocorticoids by adrenalectomy or supplemented with an excess of dexamethasone. Adrenalectomy alone did not affect the basal level of acute phase protein (APP) expression except for alpha(2)M mRNA, the level of which was enhanced. In contrast, dexamethasone treatment alone promoted full induction of alpha(2)M, significant, but not maximal increase of AGP and Hp mRNAs and suppression of Fb. In adrenalectomized rats, acute phase (AP)-cytokines, released in response to inflammation, promoted full expression of Fb and Hp and increased the level of AGP mRNA whereas alpha(2)M mRNA remained at the basal level. Inflammation in dexamethasone pretreated rats elicited changes which, in comparison to mRNA values for dexamethasone unpretreated inflamed rats, were seen as overexpression of alpha(2)M, full expression of AGP and incomplete expression of Hp, whereas Fb mRNA remained at the basal level. These data suggest that glucocorticoids are the principal inducers of a(2)M and AP-cytokines of Fb. For full induction of AGP, additive actions of glucocorticoids and AP-cytokines are required whereas expression of Hp is predominantly controlled by AP-cytokines. (C) 1998 Elsevier Science Ltd. All rights reserved.",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
title = "Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver",
volume = "66",
number = "5-6",
pages = "347-353",
doi = "10.1016/S0960-0760(98)00060-0"
}

Sevaljevic, L., Mačvanin, M., Žakula, Z., Kanazir, D. T.,& Ribarac-Stepić, N. B.. (1998). Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. in Journal of Steroid Biochemistry and Molecular Biology, 66(5-6), 347-353.
https://doi.org/10.1016/S0960-0760(98)00060-0

Sevaljevic L, Mačvanin M, Žakula Z, Kanazir DT, Ribarac-Stepić NB. Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. in Journal of Steroid Biochemistry and Molecular Biology. 1998;66(5-6):347-353.
doi:10.1016/S0960-0760(98)00060-0 .

Sevaljevic, L, Mačvanin, Mirjana, Žakula, Zorica, Kanazir, Dušan T., Ribarac-Stepić, Nevena B., "Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver" in Journal of Steroid Biochemistry and Molecular Biology, 66, no. 5-6 (1998):347-353,
https://doi.org/10.1016/S0960-0760(98)00060-0 . .