The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correla...tion with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.
Izvor:
Scientific Reports, 2021, 11, 1, 13995-
Finansiranje / projekti:
Ministry of Education, Science and Technological Development, Republic of Serbia
TY - JOUR
AU - Drljača, Tamara
AU - Zukić, Branka
AU - Kovačević, Vladimir
AU - Gemović, Branislava S.
AU - Karan-Đurašević, Teodora
AU - Perović, Vladimir R.
AU - Lazarević, Mladen
AU - Pavlović, Sonja
AU - Veljković, Nevena V.
PY - 2021
UR - https://vinar.vin.bg.ac.rs/handle/123456789/10769
AB - The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.
T2 - Scientific Reports
T1 - The first insight into the genetic structure of the population of modern Serbia
VL - 11
IS - 1
SP - 13995
DO - 10.1038/s41598-021-93129-4
ER -
@article{
author = "Drljača, Tamara and Zukić, Branka and Kovačević, Vladimir and Gemović, Branislava S. and Karan-Đurašević, Teodora and Perović, Vladimir R. and Lazarević, Mladen and Pavlović, Sonja and Veljković, Nevena V.",
year = "2021",
abstract = "The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.",
journal = "Scientific Reports",
title = "The first insight into the genetic structure of the population of modern Serbia",
volume = "11",
number = "1",
pages = "13995",
doi = "10.1038/s41598-021-93129-4"
}
Drljača, T., Zukić, B., Kovačević, V., Gemović, B. S., Karan-Đurašević, T., Perović, V. R., Lazarević, M., Pavlović, S.,& Veljković, N. V.. (2021). The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports, 11(1), 13995.
https://doi.org/10.1038/s41598-021-93129-4
Drljača T, Zukić B, Kovačević V, Gemović BS, Karan-Đurašević T, Perović VR, Lazarević M, Pavlović S, Veljković NV. The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports. 2021;11(1):13995.
doi:10.1038/s41598-021-93129-4 .
Drljača, Tamara, Zukić, Branka, Kovačević, Vladimir, Gemović, Branislava S., Karan-Đurašević, Teodora, Perović, Vladimir R., Lazarević, Mladen, Pavlović, Sonja, Veljković, Nevena V., "The first insight into the genetic structure of the population of modern Serbia" in Scientific Reports, 11, no. 1 (2021):13995,
https://doi.org/10.1038/s41598-021-93129-4 . .
