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Estradiol affects calcium transport across mitochondrial membrane in different brain regions
(Annals of the New York Academy of Sciences, 2005)
The in vitro effect of estradiol on flux of Ca2+ in the synaptosomal mitochondria from nucleus caudatus and hippocampus of chronically ovariectomized female rats was examined. No effect of estradiol on Ca2+, influx through ...
A theoretical study-of hypothalamo-pituitary adrenocortical axis dynamics
(Annals of the New York Academy of Sciences, 2005)
Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another ...
CuZn superoxide dismutase in the hippocampus and brain cortex of rats exposed to various stress conditions
(Annals of the New York Academy of Sciences, 2005)
The CuZn superoxide dismutase (CuZnSOD) protein expression in hippocampus and brain cortex of Wistar male rats exposed to acute, chronic, or combined stress was followed by Western immunoblotting. The CuZnSOD was significantly ...
Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays
(Annals of the New York Academy of Sciences, 2005)
Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area-dependent manner. In ...
Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure
(Annals of the New York Academy of Sciences, 2005)
Chronic exposure to stress alters the prooxidant-antioxidant balance, which might lead to the development of various human pathological states. In order to explain the role of antioxidant response in stress-induced injury, ...
Different effects of novel stressors on sympathoadrenal system activation in rats exposed to long-term immobilization
(Annals of the New York Academy of Sciences, 2004)
Activation of the sympathoadrenal system, evaluated by plasma levels of epinephrine (E) and norepinephrine (NE) after exposure of rats to various stressors, is well documented. However, response of rats exposed long-term ...
The effect of repeated physical exercise on hippocampus and brain cortex in stressed rats
(Annals of the New York Academy of Sciences, 2007)
Sensitivity of target cells to glucocorticoids is regulated by the expression of intracellular glucocorticoid receptor (GR), which mediates the effects of glucocorticoids. The level of GR and of its nuclear transporter ...
Response of a human melanoma cell line to low and high ionizing radiation
(Annals of the New York Academy of Sciences, 2007)
Effects of single irradiation with gamma rays and protons on human HTB140 melanoma cell growth were compared. Exponentially growing cells were irradiated close to the Bragg peak maximum of the unmodulated 62 MeV protons, ...
Viability of a human melanoma cell after single and combined treatment with fotemustine, dacarbazine, and proton irradiation
(Annals of the New York Academy of Sciences, 2007)
Viability of human HTB140 melanoma cells after being exposed to fotemustine (FM) and dacarbazine (DTIC) as well as to proton irradiation was studied. Effects of 100 and 250 mu M drugs were assessed after incubation of 6, ...
Inhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3 5,-monophosphate and tiazofurin
(Annals of the New York Academy of Sciences, 2004)
Novel antineoplastic agents, 8-chloroadenosine 3,5-monophosphate (8-Cl-cAMP) and tiazofurin (TR), have been shown to be effective against different malignant cells. Through specific mechanisms of action they modulate the ...