Estradiol affects calcium transport across mitochondrial membrane in different brain regions
The in vitro effect of estradiol on flux of Ca2+ in the synaptosomal mitochondria from nucleus caudatus and hippocampus of chronically ovariectomized female rats was examined. No effect of estradiol on Ca2+, influx through ruthenium red-sensitive channels was found. Estradiol, at a concentration of 0.05-5 nmol/L for nucleus caudatus and 0.5-5 nmol/L for the hippocampus, decreased Na-dependent Ca2+ efflux about 25%.
Keywords:calcium / estradiol / mitochondria / synaptosome / brain / rat
Source:Annals of the New York Academy of Sciences, 2005, 1048, 341-343
- 22nd International Biophysics Symposium, Oct 09-14, 2004, Belgrade, Serbia