dc.creator | Stanković, Miroslava | |
dc.creator | Horvat, Anica | |
dc.date.accessioned | 2018-03-01T20:30:40Z | |
dc.date.available | 2018-03-01T20:30:40Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0354-4664 | |
dc.identifier.issn | 1821-4339 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3505 | |
dc.description.abstract | This study addresses the in vitro protective effects of proanthocyanidins and quercetin on the frequency of micronuclei with reference to the antioxidant status of cultured human lymphocytes also subjected to 2 Gy of gamma-radiation. Treatment of lymphocytes with proanthocyanidins induced a significant decrease in the frequency of micronuclei and reduction of malonyldialdehyde production, as well as increased catalase and glutathione S-transferase activity Quercetin induces a higher incidence of micronuclei and production of malonyldialdehyde. The seven-fold increase of micronuclei frequency induced by a therapeutic dose of gamma-radiation was decreased in the presence of proanthocyanidins. These results demonstrate that proanthocyanidins may be important in the prevention of ROS-induced oxidative lymphocyte damage by decreasing DNA damage, lowering membrane lipid peroxidation, and increasing the activity AOP enzymes, as well as by reducing the level of gamma-radiation-induced DNA damage. Our results support the potential benefits of proanthocyanidins as efficient antioxidants and radioprotectors. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143044/RS// | |
dc.rights | openAccess | en |
dc.source | Archives of Biological Sciences | en |
dc.subject | micronucleus test | en |
dc.subject | flavonoids | en |
dc.subject | malonyldialdehyde | en |
dc.subject | catalase | en |
dc.subject | glutathione S-transferase | en |
dc.subject | gamma-radiation | en |
dc.subject | human lymphocytes | en |
dc.title | Properties of grape seed Proanthocyanidins and quercetin in human lymphocytes | en |
dc.type | article | en |
dcterms.abstract | Хорват, Aница; Станковиц, Мирослава; | |
dc.citation.volume | 60 | |
dc.citation.issue | 3 | |
dc.citation.spage | 367 | |
dc.citation.epage | 377 | |
dc.identifier.wos | 000258524700005 | |
dc.identifier.doi | 10.2298/ABS0803367S | |
dc.identifier.scopus | 2-s2.0-53549096234 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/12475/3501.pdf | |