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Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats
dc.creator | Gavrilović, Ljubica | |
dc.creator | Spasojević, Nataša | |
dc.creator | Dronjak, Slađana | |
dc.date.accessioned | 2018-03-01T20:09:05Z | |
dc.date.available | 2018-03-01T20:09:05Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1566-0702 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3252 | |
dc.description.abstract | In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Psychosocial stress produced a significant increase of both TH mRNA and DBH mRNA levels in stellate ganglia. Additional immobilization of long-term psychosocially stressed rats expressed no effect on gene expression of these enzymes. The results presented here suggest that psychosocial stress-induced increase in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia may be connected to the increased risk of cardiovascular disease. (C) 2009 Elsevier B.V. All rights reserved. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143044/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Autonomic Neuroscience: Basic and Clinical | en |
dc.subject | Stellate ganglia | en |
dc.subject | Psychosocial stress | en |
dc.subject | Norepinephrine | en |
dc.subject | Gene expression | en |
dc.title | Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats | en |
dc.type | article | en |
dcterms.abstract | Гавриловић Љубица; Спасојевић Наташа; Дроњак Слађана; | |
dc.citation.volume | 150 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 144 | |
dc.citation.epage | 146 | |
dc.identifier.wos | 000270472800022 | |
dc.identifier.doi | 10.1016/j.autneu.2009.05.242 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 19482560 | |
dc.identifier.scopus | 2-s2.0-69449097215 |
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