dc.creator | Kuljanin, Jadranka Ž. | |
dc.creator | Janković, Ivana A. | |
dc.creator | Nedeljković, Jovan | |
dc.creator | Prstojevic, D | |
dc.creator | Marinkovic, V | |
dc.date.accessioned | 2018-03-01T19:06:55Z | |
dc.date.available | 2018-03-01T19:06:55Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2527 | |
dc.description.abstract | The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log K(ave) = 4.50 (SD = 0.15), indicating that the Fe(III)-alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1-162.5 mug ml(-1), the detection limit being 2 mug ml(-1). The method was validated for the direct determination of alendronate in tablet dosage formulations. (C) 2002 Elsevier Science B.V. All rights reserved. | en |
dc.rights | restrictedAccess | en |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | en |
dc.subject | complex formation | en |
dc.subject | alendronate | en |
dc.subject | iron(III) chloride | en |
dc.subject | spectrophotometry | en |
dc.title | Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions | en |
dc.type | article | en |
dcterms.abstract | Куљанин, Ј; Јанковиц, И; Прстојевиц, Д; Маринковиц, В; Недељковић Јован; | |
dc.citation.volume | 28 | |
dc.citation.issue | 6 | |
dc.citation.spage | 1215 | |
dc.citation.epage | 1220 | |
dc.identifier.wos | 000176238300019 | |
dc.identifier.doi | 10.1016/S0731-7085(02)00021-3 | |
dc.citation.other | Article Number: PII S0731-7085(02)00021-3 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 12049986 | |
dc.identifier.scopus | 2-s2.0-0037097705 | |