TY  - JOUR
AU  - Tuszynski, Jack A.
AU  - Satarić, Miljko V.
AU  - Sekulić, Dalibor L.
AU  - Satarić, Bogdan M.
AU  - Zdravković, Slobodan
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8397
AB  - Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.
T2  - Biosystems
T1  - Nonlinear calcium ion waves along actin filaments control active hair–bundle motility
VL  - 173
SP  - 181
EP  - 190
DO  - 10.1016/j.biosystems.2018.08.006
ER  - 

@article{
author = "Tuszynski, Jack A. and Satarić, Miljko V. and Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan",
year = "2018",
abstract = "Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.",
journal = "Biosystems",
title = "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility",
volume = "173",
pages = "181-190",
doi = "10.1016/j.biosystems.2018.08.006"
}

Tuszynski, J. A., Satarić, M. V., Sekulić, D. L., Satarić, B. M.,& Zdravković, S.. (2018). Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems, 173, 181-190.
https://doi.org/10.1016/j.biosystems.2018.08.006

Tuszynski JA, Satarić MV, Sekulić DL, Satarić BM, Zdravković S. Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems. 2018;173:181-190.
doi:10.1016/j.biosystems.2018.08.006 .

Tuszynski, Jack A., Satarić, Miljko V., Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility" in Biosystems, 173 (2018):181-190,
https://doi.org/10.1016/j.biosystems.2018.08.006 . .

TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Sekulić, Dalibor L.
AU  - Zdravković, Slobodan
AU  - Ralević, Nebojša M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1560
AB  - It appears that so called post translational modifications of tubulin heterodimers are mostly focussed at positions of amino acid sequences of carboxy terminal tails. These changes have very profound effects on microtubule functions especially in connection with cellular traffic in terms of motor proteins. In this study, we elaborated the biophysical model aimed to explain the strategy governing these subtle interplays between structural and functional properties of microtubules. We relied onto Langevin equations including fluctuation dissipation processes. In that context we found out that small interaction between a charged motor neck domain and oppositely charged carboxy terminal tail of the a tubulin plays the decisive role in tuning kinesin-1 motor processivity along microtubules.
T2  - Journal of Theoretical Biology
T1  - A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule
VL  - 420
SP  - 152
EP  - 157
DO  - 10.1016/j.jtbi.2017.03.012
ER  - 

@article{
author = "Satarić, Miljko V. and Sekulić, Dalibor L. and Zdravković, Slobodan and Ralević, Nebojša M.",
year = "2017",
abstract = "It appears that so called post translational modifications of tubulin heterodimers are mostly focussed at positions of amino acid sequences of carboxy terminal tails. These changes have very profound effects on microtubule functions especially in connection with cellular traffic in terms of motor proteins. In this study, we elaborated the biophysical model aimed to explain the strategy governing these subtle interplays between structural and functional properties of microtubules. We relied onto Langevin equations including fluctuation dissipation processes. In that context we found out that small interaction between a charged motor neck domain and oppositely charged carboxy terminal tail of the a tubulin plays the decisive role in tuning kinesin-1 motor processivity along microtubules.",
journal = "Journal of Theoretical Biology",
title = "A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule",
volume = "420",
pages = "152-157",
doi = "10.1016/j.jtbi.2017.03.012"
}

Satarić, M. V., Sekulić, D. L., Zdravković, S.,& Ralević, N. M.. (2017). A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule. in Journal of Theoretical Biology, 420, 152-157.
https://doi.org/10.1016/j.jtbi.2017.03.012

Satarić MV, Sekulić DL, Zdravković S, Ralević NM. A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule. in Journal of Theoretical Biology. 2017;420:152-157.
doi:10.1016/j.jtbi.2017.03.012 .

Satarić, Miljko V., Sekulić, Dalibor L., Zdravković, Slobodan, Ralević, Nebojša M., "A biophysical model of how alpha-tubulin carboxy-terminal tails tune kinesin-1 processivity along microtubule" in Journal of Theoretical Biology, 420 (2017):152-157,
https://doi.org/10.1016/j.jtbi.2017.03.012 . .