Nonlinear calcium ion waves along actin filaments control active hair–bundle motility
Нема приказа
Аутори
Tuszynski, Jack A.Satarić, Miljko V.
Sekulić, Dalibor L.
Satarić, Bogdan M.
Zdravković, Slobodan
Чланак у часопису (Објављена верзија)
,
© 2018 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт
Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.
Кључне речи:
Actin filament / Calcium ion dynamics / Myosin motor / Hair cells / Nonlinear modelИзвор:
Biosystems, 2018, 173, 181-190Финансирање / пројекти:
- Provincial Secretariat for Higher Education and Scientific Research of AP Vojvodina [114-451-2708/2016-03]
- Утицај елементарних ексцитација и конформација на физичка својства нових материјала базираних на јако корелисаним нискодимензионалним системима (RS-MESTD-Basic Research (BR or ON)-171009)
- Развој метода, сензора, и система за праћење квалитета воде, ваздуха и земљишта (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43008)
- Фотоника микро и нано структурних материјала (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
- Serbian Academy of Sciences and Arts
- Natural Sciences and Engineering Research Council of Canada
DOI: 10.1016/j.biosystems.2018.08.006
ISSN: 0303-2647; 1872-8324
PubMed: 30179640
WoS: 000454965200019
Scopus: 2-s2.0-85053211779
Колекције
Институција/група
VinčaTY - JOUR AU - Tuszynski, Jack A. AU - Satarić, Miljko V. AU - Sekulić, Dalibor L. AU - Satarić, Bogdan M. AU - Zdravković, Slobodan PY - 2018 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8397 AB - Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V. T2 - Biosystems T1 - Nonlinear calcium ion waves along actin filaments control active hair–bundle motility VL - 173 SP - 181 EP - 190 DO - 10.1016/j.biosystems.2018.08.006 ER -
@article{ author = "Tuszynski, Jack A. and Satarić, Miljko V. and Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan", year = "2018", abstract = "Calcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.", journal = "Biosystems", title = "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility", volume = "173", pages = "181-190", doi = "10.1016/j.biosystems.2018.08.006" }
Tuszynski, J. A., Satarić, M. V., Sekulić, D. L., Satarić, B. M.,& Zdravković, S.. (2018). Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems, 173, 181-190. https://doi.org/10.1016/j.biosystems.2018.08.006
Tuszynski JA, Satarić MV, Sekulić DL, Satarić BM, Zdravković S. Nonlinear calcium ion waves along actin filaments control active hair–bundle motility. in Biosystems. 2018;173:181-190. doi:10.1016/j.biosystems.2018.08.006 .
Tuszynski, Jack A., Satarić, Miljko V., Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, "Nonlinear calcium ion waves along actin filaments control active hair–bundle motility" in Biosystems, 173 (2018):181-190, https://doi.org/10.1016/j.biosystems.2018.08.006 . .