TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Dobić, Sava N.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3961
AB  - pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved.
T2  - Radiation Physics and Chemistry
T1  - Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
VL  - 79
IS  - 5
SP  - 643
EP  - 649
DO  - 10.1016/j.radphyschem.2009.11.015
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Dobić, Sava N. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved.",
journal = "Radiation Physics and Chemistry",
title = "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application",
volume = "79",
number = "5",
pages = "643-649",
doi = "10.1016/j.radphyschem.2009.11.015"
}

Tomić, S. Lj., Mićić, M. M., Dobić, S. N., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry, 79(5), 643-649.
https://doi.org/10.1016/j.radphyschem.2009.11.015

Tomić SL, Mićić MM, Dobić SN, Filipović JM, Suljovrujić EH. Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry. 2010;79(5):643-649.
doi:10.1016/j.radphyschem.2009.11.015 .

Tomić, Simonida Lj., Mićić, Maja M., Dobić, Sava N., Filipović, Jovanka M., Suljovrujić, Edin H., "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application" in Radiation Physics and Chemistry, 79, no. 5 (2010):643-649,
https://doi.org/10.1016/j.radphyschem.2009.11.015 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Filipović, Jovanka M.
AU  - Suljovrujić, Edin H.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4026
AB  - In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Chemical Engineering Journal
T1  - Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels
VL  - 160
IS  - 2
SP  - 801
EP  - 809
DO  - 10.1016/j.cej.2010.03.089
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.",
year = "2010",
abstract = "In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Chemical Engineering Journal",
title = "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels",
volume = "160",
number = "2",
pages = "801-809",
doi = "10.1016/j.cej.2010.03.089"
}

Tomić, S. Lj., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal, 160(2), 801-809.
https://doi.org/10.1016/j.cej.2010.03.089

Tomić SL, Mićić MM, Filipović JM, Suljovrujić EH. Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal. 2010;160(2):801-809.
doi:10.1016/j.cej.2010.03.089 .

Tomić, Simonida Lj., Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels" in Chemical Engineering Journal, 160, no. 2 (2010):801-809,
https://doi.org/10.1016/j.cej.2010.03.089 . .

TY  - JOUR
AU  - Jovasevic, Jovana S.
AU  - Mićić, Maja M.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
AU  - Dimitrijević, Suzana I.
AU  - Tomić, Simonida Lj.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4052
AB  - New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag//P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.
T2  - Hemijska industrija
T1  - Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver
VL  - 64
IS  - 3
SP  - 209
EP  - 214
DO  - 10.2298/HEMIND091221030J
ER  - 

@article{
author = "Jovasevic, Jovana S. and Mićić, Maja M. and Suljovrujić, Edin H. and Filipović, Jovanka M. and Dimitrijević, Suzana I. and Tomić, Simonida Lj.",
year = "2010",
abstract = "New hybrid hydrogels were prepared by radical copolymerization of 2-hydroxyethyl methacrylate, itaconic acid, poly(vinylpyrrolidone) and silver salt. FTIR spectroscopy has confirmed binding of silver particles in hydrogels. Swelling studies performed in in vitro conditions showed dependence on PVP content and temperature. It can be seen that the antimicrobial activity of the Ag/P(HEMA/IA)PVP hybrid hydrogels depends on the PVP moiety and with the increase of PVP content the microbial contamination is more efficiently reduced. The best sensitivity was obtained for the polymers tested for antimicrobial activity against the yeast C. albicans, one of the most commonly encountered human pathogens, causing a wide variety of infections ranging from mucosal infections in generally healthy persons to life-threatening systemic infections in individuals with impaired immunity. A slightly less susceptible to antimicrobial effect of hydrogels was obtained for the Gram-positive bacteria S. aureus, where the reduction of cells was about 70% after two hours of exposure, for the sample with the highest PVP content. The least susceptible to the antimicrobial activity of hydrogels examined was the Gram-negative bacteria E. coli, where the percent of cell reduction was below 20%. Bearing in mind the influence of the time of exposure of microbes to the Ag//P(HEMA/IA)/PVP hybrid hydrogels, it was observed that the reduction of the number of cells depends on time, microbial culture and type of hybrid hydrogel sample. Due to their swelling and antimicrobial properties, silver/poly(2-hydroxyethyl methacrylate/itaconic acid)/poly(vinylpyrrolidone) hybrid hydrogles show potential to use in the field of biomedicine, especially for treatment of skin and burns in dermocosmetics.",
journal = "Hemijska industrija",
title = "Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver",
volume = "64",
number = "3",
pages = "209-214",
doi = "10.2298/HEMIND091221030J"
}

Jovasevic, J. S., Mićić, M. M., Suljovrujić, E. H., Filipović, J. M., Dimitrijević, S. I.,& Tomić, S. Lj.. (2010). Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver. in Hemijska industrija, 64(3), 209-214.
https://doi.org/10.2298/HEMIND091221030J

Jovasevic JS, Mićić MM, Suljovrujić EH, Filipović JM, Dimitrijević SI, Tomić SL. Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver. in Hemijska industrija. 2010;64(3):209-214.
doi:10.2298/HEMIND091221030J .

Jovasevic, Jovana S., Mićić, Maja M., Suljovrujić, Edin H., Filipović, Jovanka M., Dimitrijević, Suzana I., Tomić, Simonida Lj., "Antimicrobial Activity of Hybrid Hydrogels Based on Poly(Vinylpyrrolidone) Containing Silver" in Hemijska industrija, 64, no. 3 (2010):209-214,
https://doi.org/10.2298/HEMIND091221030J . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Mićić, Maja M.
AU  - Krezović, Bojana D.
AU  - Dobić, Sava N.
AU  - Suljovrujić, Edin H.
AU  - Filipović, Jovanka M.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3967
AB  - pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
T2  - Hemijska industrija
T1  - Smart Hydrogels Based on Itaconic Acid for Biomedical Application
VL  - 63
IS  - 6
SP  - 603
EP  - 610
DO  - 10.2298/HEMIND0906603T
ER  - 

@article{
author = "Tomić, Simonida Lj. and Mićić, Maja M. and Krezović, Bojana D. and Dobić, Sava N. and Suljovrujić, Edin H. and Filipović, Jovanka M.",
year = "2009",
abstract = "pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.",
journal = "Hemijska industrija",
title = "Smart Hydrogels Based on Itaconic Acid for Biomedical Application",
volume = "63",
number = "6",
pages = "603-610",
doi = "10.2298/HEMIND0906603T"
}

Tomić, S. Lj., Mićić, M. M., Krezović, B. D., Dobić, S. N., Suljovrujić, E. H.,& Filipović, J. M.. (2009). Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija, 63(6), 603-610.
https://doi.org/10.2298/HEMIND0906603T

Tomić SL, Mićić MM, Krezović BD, Dobić SN, Suljovrujić EH, Filipović JM. Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija. 2009;63(6):603-610.
doi:10.2298/HEMIND0906603T .

Tomić, Simonida Lj., Mićić, Maja M., Krezović, Bojana D., Dobić, Sava N., Suljovrujić, Edin H., Filipović, Jovanka M., "Smart Hydrogels Based on Itaconic Acid for Biomedical Application" in Hemijska industrija, 63, no. 6 (2009):603-610,
https://doi.org/10.2298/HEMIND0906603T . .