Smart Hydrogels Based on Itaconic Acid for Biomedical Application
Аутори
Tomić, Simonida Lj.Mićić, Maja M.
Krezović, Bojana D.
Dobić, Sava N.
Suljovrujić, Edin H.
Filipović, Jovanka M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus... the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
Кључне речи:
Hydrogels / Radiation / 2-Hydroxyethyl methacrylate / Itaconic acid / Mechanical properties / Smart hydrogels / Biocompatibility / Microbe penetrationИзвор:
Hemijska industrija, 2009, 63, 6, 603-610Финансирање / пројекти:
- Развој нанокомпозита на бази хидрогелова за примене у реконструктивној хирургији (RS-MESTD-MPN2006-2010-19027)
- Модификација, синтеза и анализа наноструктурних материјала јонским сноповима, гама зрачењем и вакуумским депоновањем (RS-MESTD-MPN2006-2010-141013)
- Регенерација скелетних ткива помогнута биоматеријалима као ткивним матрицама - ин виво и ин витро студија (RS-MESTD-MPN2006-2010-145072)
DOI: 10.2298/HEMIND0906603T
ISSN: 0367-598X
WoS: 000276140700002
Scopus: 2-s2.0-77952909341
Институција/група
VinčaTY - JOUR AU - Tomić, Simonida Lj. AU - Mićić, Maja M. AU - Krezović, Bojana D. AU - Dobić, Sava N. AU - Suljovrujić, Edin H. AU - Filipović, Jovanka M. PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3967 AB - pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. T2 - Hemijska industrija T1 - Smart Hydrogels Based on Itaconic Acid for Biomedical Application VL - 63 IS - 6 SP - 603 EP - 610 DO - 10.2298/HEMIND0906603T ER -
@article{ author = "Tomić, Simonida Lj. and Mićić, Maja M. and Krezović, Bojana D. and Dobić, Sava N. and Suljovrujić, Edin H. and Filipović, Jovanka M.", year = "2009", abstract = "pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.", journal = "Hemijska industrija", title = "Smart Hydrogels Based on Itaconic Acid for Biomedical Application", volume = "63", number = "6", pages = "603-610", doi = "10.2298/HEMIND0906603T" }
Tomić, S. Lj., Mićić, M. M., Krezović, B. D., Dobić, S. N., Suljovrujić, E. H.,& Filipović, J. M.. (2009). Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija, 63(6), 603-610. https://doi.org/10.2298/HEMIND0906603T
Tomić SL, Mićić MM, Krezović BD, Dobić SN, Suljovrujić EH, Filipović JM. Smart Hydrogels Based on Itaconic Acid for Biomedical Application. in Hemijska industrija. 2009;63(6):603-610. doi:10.2298/HEMIND0906603T .
Tomić, Simonida Lj., Mićić, Maja M., Krezović, Bojana D., Dobić, Sava N., Suljovrujić, Edin H., Filipović, Jovanka M., "Smart Hydrogels Based on Itaconic Acid for Biomedical Application" in Hemijska industrija, 63, no. 6 (2009):603-610, https://doi.org/10.2298/HEMIND0906603T . .