TY  - JOUR
AU  - Nikolić, Nadežda S.
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Dokic, Divna
AU  - Mirković, Marija D.
AU  - Bibić, Nataša M.
AU  - Trajković, Vladimir S.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3777
AB  - The present study describes for the first time a procedure for the radiolabeling of fullerene (C-60) nanocrystals (nanoC(60)) with Na I-125, as well as the biodistribution of radiolabeled nanoC(60) (I-125-nanoC(60)). The solvent exchange method with tetrahydrofuran was used to make colloidal water suspensions of radiolabeled nanoC(60) particles. The radiolabeling procedure with the addition of Na I-125 to tetrahydrofuran during dissolution of C-60 gave a higher radiochemical yield of radiolabeled nanoC(60) particles in comparison to the second option, in which Na I-125 was added after C-60 was dissolved. Using photon correlation spectroscopy and transmission electron microscopy, I-125-nanoC(60) particles were found to have a crystalline structure and a mean diameter of 200-250 nm. The I-125-nanoC(60) had a particularly high affinity for human serum albumin, displaying 95% binding efficiency after 1 h. Biodistribution studies of I-125-nanoC(60) in rats indicated significant differences in tissue accumulation of I-125-nanoC(60) and the radioactive tracer Na I-125. The higher accumulation of radiolabeled nanoC(60) was observed in liver and spleen, while accumulation in thyroid, stomach, lungs and intestines was significantly lower in comparison to Na I-125. In addition to being useful for testing the biological distribution of nanoC(60), the described radiolabeling procedure might have possible applications in cancer radiotherapy.
T2  - Nanotechnology
T1  - Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals
VL  - 20
IS  - 38
DO  - 10.1088/0957-4484/20/38/385102
ER  - 

@article{
author = "Nikolić, Nadežda S. and Vranješ-Đurić, Sanja and Janković, Drina and Dokic, Divna and Mirković, Marija D. and Bibić, Nataša M. and Trajković, Vladimir S.",
year = "2009",
abstract = "The present study describes for the first time a procedure for the radiolabeling of fullerene (C-60) nanocrystals (nanoC(60)) with Na I-125, as well as the biodistribution of radiolabeled nanoC(60) (I-125-nanoC(60)). The solvent exchange method with tetrahydrofuran was used to make colloidal water suspensions of radiolabeled nanoC(60) particles. The radiolabeling procedure with the addition of Na I-125 to tetrahydrofuran during dissolution of C-60 gave a higher radiochemical yield of radiolabeled nanoC(60) particles in comparison to the second option, in which Na I-125 was added after C-60 was dissolved. Using photon correlation spectroscopy and transmission electron microscopy, I-125-nanoC(60) particles were found to have a crystalline structure and a mean diameter of 200-250 nm. The I-125-nanoC(60) had a particularly high affinity for human serum albumin, displaying 95% binding efficiency after 1 h. Biodistribution studies of I-125-nanoC(60) in rats indicated significant differences in tissue accumulation of I-125-nanoC(60) and the radioactive tracer Na I-125. The higher accumulation of radiolabeled nanoC(60) was observed in liver and spleen, while accumulation in thyroid, stomach, lungs and intestines was significantly lower in comparison to Na I-125. In addition to being useful for testing the biological distribution of nanoC(60), the described radiolabeling procedure might have possible applications in cancer radiotherapy.",
journal = "Nanotechnology",
title = "Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals",
volume = "20",
number = "38",
doi = "10.1088/0957-4484/20/38/385102"
}

Nikolić, N. S., Vranješ-Đurić, S., Janković, D., Dokic, D., Mirković, M. D., Bibić, N. M.,& Trajković, V. S.. (2009). Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals. in Nanotechnology, 20(38).
https://doi.org/10.1088/0957-4484/20/38/385102

Nikolić NS, Vranješ-Đurić S, Janković D, Dokic D, Mirković MD, Bibić NM, Trajković VS. Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals. in Nanotechnology. 2009;20(38).
doi:10.1088/0957-4484/20/38/385102 .

Nikolić, Nadežda S., Vranješ-Đurić, Sanja, Janković, Drina, Dokic, Divna, Mirković, Marija D., Bibić, Nataša M., Trajković, Vladimir S., "Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals" in Nanotechnology, 20, no. 38 (2009),
https://doi.org/10.1088/0957-4484/20/38/385102 . .