Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals
Нема приказа
Аутори
Nikolić, Nadežda S.Vranješ-Đurić, Sanja
Janković, Drina
Dokic, Divna
Mirković, Marija D.
Bibić, Nataša M.
Trajković, Vladimir S.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The present study describes for the first time a procedure for the radiolabeling of fullerene (C-60) nanocrystals (nanoC(60)) with Na I-125, as well as the biodistribution of radiolabeled nanoC(60) (I-125-nanoC(60)). The solvent exchange method with tetrahydrofuran was used to make colloidal water suspensions of radiolabeled nanoC(60) particles. The radiolabeling procedure with the addition of Na I-125 to tetrahydrofuran during dissolution of C-60 gave a higher radiochemical yield of radiolabeled nanoC(60) particles in comparison to the second option, in which Na I-125 was added after C-60 was dissolved. Using photon correlation spectroscopy and transmission electron microscopy, I-125-nanoC(60) particles were found to have a crystalline structure and a mean diameter of 200-250 nm. The I-125-nanoC(60) had a particularly high affinity for human serum albumin, displaying 95% binding efficiency after 1 h. Biodistribution studies of I-125-nanoC(60) in rats indicated significant differences ...in tissue accumulation of I-125-nanoC(60) and the radioactive tracer Na I-125. The higher accumulation of radiolabeled nanoC(60) was observed in liver and spleen, while accumulation in thyroid, stomach, lungs and intestines was significantly lower in comparison to Na I-125. In addition to being useful for testing the biological distribution of nanoC(60), the described radiolabeling procedure might have possible applications in cancer radiotherapy.
Извор:
Nanotechnology, 2009, 20, 38Финансирање / пројекти:
- Ministry of Science and Technology of the Republic of Serbia [145073, 169009]
DOI: 10.1088/0957-4484/20/38/385102
ISSN: 0957-4484
PubMed: 19713574
WoS: 000269356900002
Scopus: 2-s2.0-70349084624
Колекције
Институција/група
VinčaTY - JOUR AU - Nikolić, Nadežda S. AU - Vranješ-Đurić, Sanja AU - Janković, Drina AU - Dokic, Divna AU - Mirković, Marija D. AU - Bibić, Nataša M. AU - Trajković, Vladimir S. PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3777 AB - The present study describes for the first time a procedure for the radiolabeling of fullerene (C-60) nanocrystals (nanoC(60)) with Na I-125, as well as the biodistribution of radiolabeled nanoC(60) (I-125-nanoC(60)). The solvent exchange method with tetrahydrofuran was used to make colloidal water suspensions of radiolabeled nanoC(60) particles. The radiolabeling procedure with the addition of Na I-125 to tetrahydrofuran during dissolution of C-60 gave a higher radiochemical yield of radiolabeled nanoC(60) particles in comparison to the second option, in which Na I-125 was added after C-60 was dissolved. Using photon correlation spectroscopy and transmission electron microscopy, I-125-nanoC(60) particles were found to have a crystalline structure and a mean diameter of 200-250 nm. The I-125-nanoC(60) had a particularly high affinity for human serum albumin, displaying 95% binding efficiency after 1 h. Biodistribution studies of I-125-nanoC(60) in rats indicated significant differences in tissue accumulation of I-125-nanoC(60) and the radioactive tracer Na I-125. The higher accumulation of radiolabeled nanoC(60) was observed in liver and spleen, while accumulation in thyroid, stomach, lungs and intestines was significantly lower in comparison to Na I-125. In addition to being useful for testing the biological distribution of nanoC(60), the described radiolabeling procedure might have possible applications in cancer radiotherapy. T2 - Nanotechnology T1 - Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals VL - 20 IS - 38 DO - 10.1088/0957-4484/20/38/385102 ER -
@article{ author = "Nikolić, Nadežda S. and Vranješ-Đurić, Sanja and Janković, Drina and Dokic, Divna and Mirković, Marija D. and Bibić, Nataša M. and Trajković, Vladimir S.", year = "2009", abstract = "The present study describes for the first time a procedure for the radiolabeling of fullerene (C-60) nanocrystals (nanoC(60)) with Na I-125, as well as the biodistribution of radiolabeled nanoC(60) (I-125-nanoC(60)). The solvent exchange method with tetrahydrofuran was used to make colloidal water suspensions of radiolabeled nanoC(60) particles. The radiolabeling procedure with the addition of Na I-125 to tetrahydrofuran during dissolution of C-60 gave a higher radiochemical yield of radiolabeled nanoC(60) particles in comparison to the second option, in which Na I-125 was added after C-60 was dissolved. Using photon correlation spectroscopy and transmission electron microscopy, I-125-nanoC(60) particles were found to have a crystalline structure and a mean diameter of 200-250 nm. The I-125-nanoC(60) had a particularly high affinity for human serum albumin, displaying 95% binding efficiency after 1 h. Biodistribution studies of I-125-nanoC(60) in rats indicated significant differences in tissue accumulation of I-125-nanoC(60) and the radioactive tracer Na I-125. The higher accumulation of radiolabeled nanoC(60) was observed in liver and spleen, while accumulation in thyroid, stomach, lungs and intestines was significantly lower in comparison to Na I-125. In addition to being useful for testing the biological distribution of nanoC(60), the described radiolabeling procedure might have possible applications in cancer radiotherapy.", journal = "Nanotechnology", title = "Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals", volume = "20", number = "38", doi = "10.1088/0957-4484/20/38/385102" }
Nikolić, N. S., Vranješ-Đurić, S., Janković, D., Dokic, D., Mirković, M. D., Bibić, N. M.,& Trajković, V. S.. (2009). Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals. in Nanotechnology, 20(38). https://doi.org/10.1088/0957-4484/20/38/385102
Nikolić NS, Vranješ-Đurić S, Janković D, Dokic D, Mirković MD, Bibić NM, Trajković VS. Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals. in Nanotechnology. 2009;20(38). doi:10.1088/0957-4484/20/38/385102 .
Nikolić, Nadežda S., Vranješ-Đurić, Sanja, Janković, Drina, Dokic, Divna, Mirković, Marija D., Bibić, Nataša M., Trajković, Vladimir S., "Preparation and biodistribution of radiolabeled fullerene C-60 nanocrystals" in Nanotechnology, 20, no. 38 (2009), https://doi.org/10.1088/0957-4484/20/38/385102 . .