TY  - JOUR
AU  - Stojanović, Marko
AU  - Lalatović, Jovana
AU  - Milosavljević, Aleksandra
AU  - Savić, Nada
AU  - Simms, Charlotte
AU  - Radosavljević, Branimir
AU  - Ćetković, Mila
AU  - Kravić Stevović, Tamara
AU  - Mrda, Davor
AU  - Čolović, Mirjana B.
AU  - Parac-Vogt, Tatjana N.
AU  - Krstić, Danijela
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11091
AB  - In this study, we demonstrate for the first time, that a discrete metal-oxo cluster α-/β-K 6 P 2 W 18 O 62 (WD-POM) exhibits superior performance as a computed tomography (CT) contrast agent, in comparison to the standard contrast agent iohexol. A toxicity evaluation of WD-POM was performed according to standard toxicological protocols using Wistar albino rats. The maximum tolerable dose (MTD) of 2000 mg/kg was initially determined after oral WD-POM application. The acute intravenous toxicity of single WD-POM doses (1/3, 1/5, and 1/10 MTD), which are at least fifty times higher than the typically used dose (0.015 mmol W kg −1 ) of tungsten-based contrast agents, was evaluated for 14 days. The results of arterial blood gas analysis, CO-oximetry status, electrolyte and lactate levels for 1/10 MTD group (80% survival rate) indicated the mixed respiratory and metabolic acidosis. The highest deposition of WD-POM (0.6 ppm tungsten) was found in the kidney, followed by liver (0.15 ppm tungsten), for which the histological analysis revealed morphological irregularities, although the renal function parameters (creatinine and BUN levels) were within the physiological range. This study is the first and important step in evaluating side effects of polyoxometalate nanoclusters, which in recent years have shown a large potential as therapeutics and contrast agents.
T2  - Scientific Reports
T1  - In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography
VL  - 13
IS  - 1
SP  - 9140
DO  - 10.1038/s41598-023-36317-8
ER  - 

@article{
author = "Stojanović, Marko and Lalatović, Jovana and Milosavljević, Aleksandra and Savić, Nada and Simms, Charlotte and Radosavljević, Branimir and Ćetković, Mila and Kravić Stevović, Tamara and Mrda, Davor and Čolović, Mirjana B. and Parac-Vogt, Tatjana N. and Krstić, Danijela",
year = "2023",
abstract = "In this study, we demonstrate for the first time, that a discrete metal-oxo cluster α-/β-K 6 P 2 W 18 O 62 (WD-POM) exhibits superior performance as a computed tomography (CT) contrast agent, in comparison to the standard contrast agent iohexol. A toxicity evaluation of WD-POM was performed according to standard toxicological protocols using Wistar albino rats. The maximum tolerable dose (MTD) of 2000 mg/kg was initially determined after oral WD-POM application. The acute intravenous toxicity of single WD-POM doses (1/3, 1/5, and 1/10 MTD), which are at least fifty times higher than the typically used dose (0.015 mmol W kg −1 ) of tungsten-based contrast agents, was evaluated for 14 days. The results of arterial blood gas analysis, CO-oximetry status, electrolyte and lactate levels for 1/10 MTD group (80% survival rate) indicated the mixed respiratory and metabolic acidosis. The highest deposition of WD-POM (0.6 ppm tungsten) was found in the kidney, followed by liver (0.15 ppm tungsten), for which the histological analysis revealed morphological irregularities, although the renal function parameters (creatinine and BUN levels) were within the physiological range. This study is the first and important step in evaluating side effects of polyoxometalate nanoclusters, which in recent years have shown a large potential as therapeutics and contrast agents.",
journal = "Scientific Reports",
title = "In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography",
volume = "13",
number = "1",
pages = "9140",
doi = "10.1038/s41598-023-36317-8"
}

Stojanović, M., Lalatović, J., Milosavljević, A., Savić, N., Simms, C., Radosavljević, B., Ćetković, M., Kravić Stevović, T., Mrda, D., Čolović, M. B., Parac-Vogt, T. N.,& Krstić, D.. (2023). In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography. in Scientific Reports, 13(1), 9140.
https://doi.org/10.1038/s41598-023-36317-8

Stojanović M, Lalatović J, Milosavljević A, Savić N, Simms C, Radosavljević B, Ćetković M, Kravić Stevović T, Mrda D, Čolović MB, Parac-Vogt TN, Krstić D. In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography. in Scientific Reports. 2023;13(1):9140.
doi:10.1038/s41598-023-36317-8 .

Stojanović, Marko, Lalatović, Jovana, Milosavljević, Aleksandra, Savić, Nada, Simms, Charlotte, Radosavljević, Branimir, Ćetković, Mila, Kravić Stevović, Tamara, Mrda, Davor, Čolović, Mirjana B., Parac-Vogt, Tatjana N., Krstić, Danijela, "In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography" in Scientific Reports, 13, no. 1 (2023):9140,
https://doi.org/10.1038/s41598-023-36317-8 . .

TY  - CONF
AU  - Domijan, Ana-Marija
AU  - Gajski, Goran
AU  - Gerić, M.
AU  - Savić, Nada
AU  - Parac-Vogt, Tatjana
AU  - Krstić, Danijela
AU  - Čolović, Mirjana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12926
AB  - In this study, prooxidative properties of three Wells-Dawson polyoxometalates (POMs) previously reported as promising contrast-enhancing staining agents for micro-computed tomography (microCT): parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2), were evaluated in vitro. In this aim, malondialdehyde (MDA) level, as an indicator of prooxidant action and lipid peroxidation, was determined in human plasma after 24 h treatment with the POMs in the concentration range 1-100 μM at 37 °C. The results demonstrated that the studied POMs did not induce an increase in plasma lipid peroxidation level compared to the corresponding control. Thus, it could be concluded that the investigated POM-based contrast agent candidates for microCT are not sufficiently potent prooxidants capable to cause membrane damage and consequent toxic occurrences.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
T1  - In vitro toxicity evaluation of potential contrast agents for micro-computed tomography: effect on cell membrane
VL  - 1
SP  - 283
EP  - 286
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12926
ER  - 

@conference{
author = "Domijan, Ana-Marija and Gajski, Goran and Gerić, M. and Savić, Nada and Parac-Vogt, Tatjana and Krstić, Danijela and Čolović, Mirjana",
year = "2022",
abstract = "In this study, prooxidative properties of three Wells-Dawson polyoxometalates (POMs) previously reported as promising contrast-enhancing staining agents for micro-computed tomography (microCT): parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2), were evaluated in vitro. In this aim, malondialdehyde (MDA) level, as an indicator of prooxidant action and lipid peroxidation, was determined in human plasma after 24 h treatment with the POMs in the concentration range 1-100 μM at 37 °C. The results demonstrated that the studied POMs did not induce an increase in plasma lipid peroxidation level compared to the corresponding control. Thus, it could be concluded that the investigated POM-based contrast agent candidates for microCT are not sufficiently potent prooxidants capable to cause membrane damage and consequent toxic occurrences.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings",
title = "In vitro toxicity evaluation of potential contrast agents for micro-computed tomography: effect on cell membrane",
volume = "1",
pages = "283-286",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12926"
}

Domijan, A., Gajski, G., Gerić, M., Savić, N., Parac-Vogt, T., Krstić, D.,& Čolović, M.. (2022). In vitro toxicity evaluation of potential contrast agents for micro-computed tomography: effect on cell membrane. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 283-286.
https://hdl.handle.net/21.15107/rcub_vinar_12926

Domijan A, Gajski G, Gerić M, Savić N, Parac-Vogt T, Krstić D, Čolović M. In vitro toxicity evaluation of potential contrast agents for micro-computed tomography: effect on cell membrane. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings. 2022;1:283-286.
https://hdl.handle.net/21.15107/rcub_vinar_12926 .

Domijan, Ana-Marija, Gajski, Goran, Gerić, M., Savić, Nada, Parac-Vogt, Tatjana, Krstić, Danijela, Čolović, Mirjana, "In vitro toxicity evaluation of potential contrast agents for micro-computed tomography: effect on cell membrane" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings, 1 (2022):283-286,
https://hdl.handle.net/21.15107/rcub_vinar_12926 .

TY  - CONF
AU  - Čolović, Mirjana
AU  - Gajski, Goran
AU  - Gerić, M.
AU  - Savić, Nada
AU  - Krstić, Danijela
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12924
AB  - Cytotoxicity assessment in vitro of three Wells-Dawson polyoxometalates (POMs) as contrast-enhancing staining agent (CESA) candidates: parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2), was carried out on healthy non-target human blood cells. Whole blood samples were treated with these POMs (1-100 μM) for 4 and 24 h at 37 °C. The results showed a time-dependent decrease of the peripheral blood mononuclear cell (PBMC) viability for all investigated polyoxotungstates. The 4 h treatment induced a significant cytotoxic effect only for the higher concentrations of Hf-WD 1:2, whereas 24 h exposure resulted in a concentration-dependent alteration of the cell viability. The most potent cytotoxic activity was obtained for Hf-WD 1:2 inducing a decrease of the cell viability from 25 to 45% compared to the corresponding control. The weakest effect was observed for parent WD, which resulted in no statistically significant difference in PBMC viability in respect to the control at the concentration of 1 μM. Finally, parent WD, lacunary WD, and Hf-WD 1:2 could not be considered safe from a cytotoxic point of view, thus further more extensive toxicity studies are needed.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
T1  - Cytotoxicity evaluation of promising staining agents for contrast-enhanced microfocus computed tomography
VL  - 1
SP  - 275
EP  - 278
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12924
ER  - 

@conference{
author = "Čolović, Mirjana and Gajski, Goran and Gerić, M. and Savić, Nada and Krstić, Danijela",
year = "2022",
abstract = "Cytotoxicity assessment in vitro of three Wells-Dawson polyoxometalates (POMs) as contrast-enhancing staining agent (CESA) candidates: parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2), was carried out on healthy non-target human blood cells. Whole blood samples were treated with these POMs (1-100 μM) for 4 and 24 h at 37 °C. The results showed a time-dependent decrease of the peripheral blood mononuclear cell (PBMC) viability for all investigated polyoxotungstates. The 4 h treatment induced a significant cytotoxic effect only for the higher concentrations of Hf-WD 1:2, whereas 24 h exposure resulted in a concentration-dependent alteration of the cell viability. The most potent cytotoxic activity was obtained for Hf-WD 1:2 inducing a decrease of the cell viability from 25 to 45% compared to the corresponding control. The weakest effect was observed for parent WD, which resulted in no statistically significant difference in PBMC viability in respect to the control at the concentration of 1 μM. Finally, parent WD, lacunary WD, and Hf-WD 1:2 could not be considered safe from a cytotoxic point of view, thus further more extensive toxicity studies are needed.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings",
title = "Cytotoxicity evaluation of promising staining agents for contrast-enhanced microfocus computed tomography",
volume = "1",
pages = "275-278",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12924"
}

Čolović, M., Gajski, G., Gerić, M., Savić, N.,& Krstić, D.. (2022). Cytotoxicity evaluation of promising staining agents for contrast-enhanced microfocus computed tomography. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 275-278.
https://hdl.handle.net/21.15107/rcub_vinar_12924

Čolović M, Gajski G, Gerić M, Savić N, Krstić D. Cytotoxicity evaluation of promising staining agents for contrast-enhanced microfocus computed tomography. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings. 2022;1:275-278.
https://hdl.handle.net/21.15107/rcub_vinar_12924 .

Čolović, Mirjana, Gajski, Goran, Gerić, M., Savić, Nada, Krstić, Danijela, "Cytotoxicity evaluation of promising staining agents for contrast-enhanced microfocus computed tomography" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings, 1 (2022):275-278,
https://hdl.handle.net/21.15107/rcub_vinar_12924 .

TY  - CONF
AU  - Čolović, Mirjana
AU  - Domijan, Ana-Marija
AU  - Gajski, Goran
AU  - Gerić, M.
AU  - Parac-Vogt, Tatjana
AU  - Krstić, Danijela
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12925
AB  - The aim of this study to assess in vitro prooxidative properties of three polyoxometalate (POM)-based species that were found as potential contrast-enhancing staining agents for micro-computed tomography (microCT) to visualize kidney and bone tissues: parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2). Thus, reduced glutathione (GSH) concentration, as a major antioxidant to prevent reactive oxygen species (ROS) attack and an indicator of oxidative stress, was followed in human plasma after 24 h exposure to the POMs within the concentration range 1-100 μM at 37 °C. The promising contrast agents exhibited various prooxidative properties. Parent WD did not significantly influence GSH level, thus prooxidative properties could not be associated with this POM species. On the contrary, Hf-WD 1:2 exposure resulted in a significant decrease in GSH concentration in human plasma compared to untreated control. Accordingly, Hf-WD 1:2 might be regarded as a prooxidant agent that could cause oxidative stress and consequent toxic occurrences. Nevertheless, additional studies on other relevant oxidative stress parameters are needed to confirm this assumption.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
T1  - Prooxidative properties of contrast agent candidates for micro-computed tomography
VL  - 1
SP  - 279
EP  - 282
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12925
ER  - 

@conference{
author = "Čolović, Mirjana and Domijan, Ana-Marija and Gajski, Goran and Gerić, M. and Parac-Vogt, Tatjana and Krstić, Danijela",
year = "2022",
abstract = "The aim of this study to assess in vitro prooxidative properties of three polyoxometalate (POM)-based species that were found as potential contrast-enhancing staining agents for micro-computed tomography (microCT) to visualize kidney and bone tissues: parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2). Thus, reduced glutathione (GSH) concentration, as a major antioxidant to prevent reactive oxygen species (ROS) attack and an indicator of oxidative stress, was followed in human plasma after 24 h exposure to the POMs within the concentration range 1-100 μM at 37 °C. The promising contrast agents exhibited various prooxidative properties. Parent WD did not significantly influence GSH level, thus prooxidative properties could not be associated with this POM species. On the contrary, Hf-WD 1:2 exposure resulted in a significant decrease in GSH concentration in human plasma compared to untreated control. Accordingly, Hf-WD 1:2 might be regarded as a prooxidant agent that could cause oxidative stress and consequent toxic occurrences. Nevertheless, additional studies on other relevant oxidative stress parameters are needed to confirm this assumption.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings",
title = "Prooxidative properties of contrast agent candidates for micro-computed tomography",
volume = "1",
pages = "279-282",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12925"
}

Čolović, M., Domijan, A., Gajski, G., Gerić, M., Parac-Vogt, T.,& Krstić, D.. (2022). Prooxidative properties of contrast agent candidates for micro-computed tomography. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 279-282.
https://hdl.handle.net/21.15107/rcub_vinar_12925

Čolović M, Domijan A, Gajski G, Gerić M, Parac-Vogt T, Krstić D. Prooxidative properties of contrast agent candidates for micro-computed tomography. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings. 2022;1:279-282.
https://hdl.handle.net/21.15107/rcub_vinar_12925 .

Čolović, Mirjana, Domijan, Ana-Marija, Gajski, Goran, Gerić, M., Parac-Vogt, Tatjana, Krstić, Danijela, "Prooxidative properties of contrast agent candidates for micro-computed tomography" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings, 1 (2022):279-282,
https://hdl.handle.net/21.15107/rcub_vinar_12925 .

TY  - CONF
AU  - Čolović, Mirjana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12921
AB  - Cytotoxicity and prooxidative properties evaluation of three Wells-Dawson polyoxotungstates that were published as potential contrast-enhancing staining agent (CESA) candidates for micro-computed tomography (microCT): parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2), was carried out in vitro. Oxidative stress indicators, reduced glutathione (GSH) and malondialdehyde (MDA) levels were determined in human blood plasma after 4 and 24 h treatment with the selected polyoxotungstates, within the concentration range 1-100 μM at 37 °C, and polyoxotungstate-induced cytotoxicity was assessed by monitoring cell viability in peripheral blood mononuclear cells (PBMCs). The results demonstrated that each of the studied promising CESAs resulted in a decrease of human PBMC viability in concentration- and time-dependent manner, and Hf-WD 1:2 exhibited the strongest cytotoxic properties inducing up to 50% decrease of the cell viability related to corresponding control. However, only Hf-WD 1:2 might be considered a potential prooxidant that resulted in a significant decrease of human plasma GSH level, whereas none of the investigated polyoxotungstates did not cause membrane lipid damage. Conclusively, parent WD, lacunary WD, and Hf-WD 1:2 could not be considered safe primarily from a cytotoxic point of view, thus more extensive in vitro and in vivo studies are needed for the toxicological profile assessment of the studied promising CESA candidates for the soft tissue visualization using microCT.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
T1  - Toxicity evaluation of promising contrast-enhancing staining agents
VL  - 2
SP  - 573
EP  - 576
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12921
ER  - 

@conference{
author = "Čolović, Mirjana",
year = "2022",
abstract = "Cytotoxicity and prooxidative properties evaluation of three Wells-Dawson polyoxotungstates that were published as potential contrast-enhancing staining agent (CESA) candidates for micro-computed tomography (microCT): parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2), was carried out in vitro. Oxidative stress indicators, reduced glutathione (GSH) and malondialdehyde (MDA) levels were determined in human blood plasma after 4 and 24 h treatment with the selected polyoxotungstates, within the concentration range 1-100 μM at 37 °C, and polyoxotungstate-induced cytotoxicity was assessed by monitoring cell viability in peripheral blood mononuclear cells (PBMCs). The results demonstrated that each of the studied promising CESAs resulted in a decrease of human PBMC viability in concentration- and time-dependent manner, and Hf-WD 1:2 exhibited the strongest cytotoxic properties inducing up to 50% decrease of the cell viability related to corresponding control. However, only Hf-WD 1:2 might be considered a potential prooxidant that resulted in a significant decrease of human plasma GSH level, whereas none of the investigated polyoxotungstates did not cause membrane lipid damage. Conclusively, parent WD, lacunary WD, and Hf-WD 1:2 could not be considered safe primarily from a cytotoxic point of view, thus more extensive in vitro and in vivo studies are needed for the toxicological profile assessment of the studied promising CESA candidates for the soft tissue visualization using microCT.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings",
title = "Toxicity evaluation of promising contrast-enhancing staining agents",
volume = "2",
pages = "573-576",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12921"
}

Čolović, M.. (2022). Toxicity evaluation of promising contrast-enhancing staining agents. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 2, 573-576.
https://hdl.handle.net/21.15107/rcub_vinar_12921

Čolović M. Toxicity evaluation of promising contrast-enhancing staining agents. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings. 2022;2:573-576.
https://hdl.handle.net/21.15107/rcub_vinar_12921 .

Čolović, Mirjana, "Toxicity evaluation of promising contrast-enhancing staining agents" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings, 2 (2022):573-576,
https://hdl.handle.net/21.15107/rcub_vinar_12921 .