@conference{
author = "Domijan, Ana-Marija and Gajski, Goran and Gerić, M. and Savić, Nada and Parac-Vogt, Tatjana and Krstić, Danijela and Čolović, Mirjana",
year = "2022",
abstract = "In this study, prooxidative properties of three Wells-Dawson polyoxometalates (POMs) previously reported as promising contrast-enhancing staining agents for micro-computed tomography (microCT): parent Wells-Dawson POM α2-K6P2W18O62.14H2O (parent WD), monolacunary Wells-Dawson POM α2-K10P2W17O61.20H2O (lacunary WD), and 1:2 hafnium(IV)-substituted Wells-Dawson POM K16[Hf(α2-P2W17O61)2]·19H2O (Hf-WD 1:2), were evaluated in vitro. In this aim, malondialdehyde (MDA) level, as an indicator of prooxidant action and lipid peroxidation, was determined in human plasma after 24 h treatment with the POMs in the concentration range 1-100 μM at 37 °C. The results demonstrated that the studied POMs did not induce an increase in plasma lipid peroxidation level compared to the corresponding control. Thus, it could be concluded that the investigated POM-based contrast agent candidates for microCT are not sufficiently potent prooxidants capable to cause membrane damage and consequent toxic occurrences.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Proceedings",
title = "In vitro toxicity evaluation of potential contrast agents for micro-computed tomography: effect on cell membrane",
volume = "1",
pages = "283-286",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12926"
}