TY  - JOUR
AU  - Sekulić, Dalibor L.
AU  - Satarić, Bogdan M.
AU  - Zdravković, Slobodan
AU  - Bugay, Aleksandr N.
AU  - Satarić, Miljko V.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1225
AB  - The mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing.
T2  - Chaos
T1  - Nonlinear dynamics of C-terminal tails in cellular microtubules
VL  - 26
IS  - 7
DO  - 10.1063/1.4959802
ER  - 

@article{
author = "Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan and Bugay, Aleksandr N. and Satarić, Miljko V.",
year = "2016",
abstract = "The mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing.",
journal = "Chaos",
title = "Nonlinear dynamics of C-terminal tails in cellular microtubules",
volume = "26",
number = "7",
doi = "10.1063/1.4959802"
}

Sekulić, D. L., Satarić, B. M., Zdravković, S., Bugay, A. N.,& Satarić, M. V.. (2016). Nonlinear dynamics of C-terminal tails in cellular microtubules. in Chaos, 26(7).
https://doi.org/10.1063/1.4959802

Sekulić DL, Satarić BM, Zdravković S, Bugay AN, Satarić MV. Nonlinear dynamics of C-terminal tails in cellular microtubules. in Chaos. 2016;26(7).
doi:10.1063/1.4959802 .

Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, Bugay, Aleksandr N., Satarić, Miljko V., "Nonlinear dynamics of C-terminal tails in cellular microtubules" in Chaos, 26, no. 7 (2016),
https://doi.org/10.1063/1.4959802 . .