Nonlinear dynamics of C-terminal tails in cellular microtubules
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Аутори
Sekulić, Dalibor L.Satarić, Bogdan M.
Zdravković, Slobodan
Bugay, Aleksandr N.
Satarić, Miljko V.
Чланак у часопису (Објављена верзија)
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The mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in... microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing.
Извор:
Chaos, 2016, 26, 7Финансирање / пројекти:
- Утицај елементарних ексцитација и конформација на физичка својства нових материјала базираних на јако корелисаним нискодимензионалним системима (RS-MESTD-Basic Research (BR or ON)-171009)
- Развој метода, сензора, и система за праћење квалитета воде, ваздуха и земљишта (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43008)
- Фотоника микро и нано структурних материјала (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45010)
- Provincial Secretariat of Science and Technological Development of AP Vojvodina [114-451-2708/2016-03]
- Russian Foundation for Basic Research [16-02-00453a]
- Joint Institute for Nuclear Research, Dubna, Russian Federation
- Ministry of Science, Education and Technological Development of the Republic of Serbia
DOI: 10.1063/1.4959802
ISSN: 1054-1500; 1089-7682
PubMed: 27475079
WoS: 000382404700019
Scopus: 2-s2.0-85026628470
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Институција/група
VinčaTY - JOUR AU - Sekulić, Dalibor L. AU - Satarić, Bogdan M. AU - Zdravković, Slobodan AU - Bugay, Aleksandr N. AU - Satarić, Miljko V. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1225 AB - The mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing. T2 - Chaos T1 - Nonlinear dynamics of C-terminal tails in cellular microtubules VL - 26 IS - 7 DO - 10.1063/1.4959802 ER -
@article{ author = "Sekulić, Dalibor L. and Satarić, Bogdan M. and Zdravković, Slobodan and Bugay, Aleksandr N. and Satarić, Miljko V.", year = "2016", abstract = "The mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing.", journal = "Chaos", title = "Nonlinear dynamics of C-terminal tails in cellular microtubules", volume = "26", number = "7", doi = "10.1063/1.4959802" }
Sekulić, D. L., Satarić, B. M., Zdravković, S., Bugay, A. N.,& Satarić, M. V.. (2016). Nonlinear dynamics of C-terminal tails in cellular microtubules. in Chaos, 26(7). https://doi.org/10.1063/1.4959802
Sekulić DL, Satarić BM, Zdravković S, Bugay AN, Satarić MV. Nonlinear dynamics of C-terminal tails in cellular microtubules. in Chaos. 2016;26(7). doi:10.1063/1.4959802 .
Sekulić, Dalibor L., Satarić, Bogdan M., Zdravković, Slobodan, Bugay, Aleksandr N., Satarić, Miljko V., "Nonlinear dynamics of C-terminal tails in cellular microtubules" in Chaos, 26, no. 7 (2016), https://doi.org/10.1063/1.4959802 . .