TY  - JOUR
AU  - Drljača, Tamara
AU  - Zukić, Branka
AU  - Kovačević, Vladimir
AU  - Gemović, Branislava S.
AU  - Karan-Đurašević, Teodora
AU  - Perović, Vladimir R.
AU  - Lazarević, Mladen
AU  - Pavlović, Sonja
AU  - Veljković, Nevena V.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10769
AB  - The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.
T2  - Scientific Reports
T1  - The first insight into the genetic structure of the population of modern Serbia
VL  - 11
IS  - 1
SP  - 13995
DO  - 10.1038/s41598-021-93129-4
ER  - 

@article{
author = "Drljača, Tamara and Zukić, Branka and Kovačević, Vladimir and Gemović, Branislava S. and Karan-Đurašević, Teodora and Perović, Vladimir R. and Lazarević, Mladen and Pavlović, Sonja and Veljković, Nevena V.",
year = "2021",
abstract = "The complete understanding of the genomic contribution to complex traits, diseases, and response to treatments, as well as genomic medicine application to the well-being of all humans will be achieved through the global variome that encompasses fine-scale genetic diversity. Despite significant efforts in recent years, uneven representation still characterizes genomic resources and among the underrepresented European populations are the Western Balkans including the Serbian population. Our research addresses this gap and presents the first ever targeted sequencing dataset of variants in clinically relevant genes. By measuring population differentiation and applying the Principal Component and Admixture analysis we demonstrated that the Serbian population differs little from other European populations, yet we identified several novel and more frequent variants that appear as its unique genetic determinants. We explored thoroughly the functional impact of frequent variants and its correlation with the health burden of the population of Serbia based on a sample of 144 individuals. Our variants catalogue improves the understanding of genetics of modern Serbia, contributes to research on ancestry, and aids in improvements of well-being and health equity. In addition, this resource may also be applicable in neighboring regions and valuable in worldwide functional analyses of genetic variants in individuals of European descent.",
journal = "Scientific Reports",
title = "The first insight into the genetic structure of the population of modern Serbia",
volume = "11",
number = "1",
pages = "13995",
doi = "10.1038/s41598-021-93129-4"
}

Drljača, T., Zukić, B., Kovačević, V., Gemović, B. S., Karan-Đurašević, T., Perović, V. R., Lazarević, M., Pavlović, S.,& Veljković, N. V.. (2021). The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports, 11(1), 13995.
https://doi.org/10.1038/s41598-021-93129-4

Drljača T, Zukić B, Kovačević V, Gemović BS, Karan-Đurašević T, Perović VR, Lazarević M, Pavlović S, Veljković NV. The first insight into the genetic structure of the population of modern Serbia. in Scientific Reports. 2021;11(1):13995.
doi:10.1038/s41598-021-93129-4 .

Drljača, Tamara, Zukić, Branka, Kovačević, Vladimir, Gemović, Branislava S., Karan-Đurašević, Teodora, Perović, Vladimir R., Lazarević, Mladen, Pavlović, Sonja, Veljković, Nevena V., "The first insight into the genetic structure of the population of modern Serbia" in Scientific Reports, 11, no. 1 (2021):13995,
https://doi.org/10.1038/s41598-021-93129-4 . .

TY  - CHAP
AU  - Grković, Ivana
AU  - Mitrović, Nataša Lj.
AU  - Dragić, Milorad
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10095
AB  - Extracellular purine nucleotides, such as adenosine 5′-triphosphate (ATP), are important modulators of hippocampal function and plasticity. In the extracellular space, ATP is inherently short-lived molecule, which undergoes rapid enzymatic degradation to adenosine by ectonucleotidases. Given that ectonucleotidases have distinct and overlapping distribution in the hippocampus, and as ovarian hormones participate in a formation, maturation, and a refinement of synaptic contacts, both during development and in adulthood, the present chapter summarizes known data about spatial distribution of selected ecto-enzymes and estradiol-induced effects on ectonucleotidases in the rat hippocampus.
T2  - Vitamins and Hormones
T1  - Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement
VL  - 118
SP  - 199
EP  - 221
DO  - 10.1016/bs.vh.2021.11.005
ER  - 

@inbook{
author = "Grković, Ivana and Mitrović, Nataša Lj. and Dragić, Milorad",
year = "2021",
abstract = "Extracellular purine nucleotides, such as adenosine 5′-triphosphate (ATP), are important modulators of hippocampal function and plasticity. In the extracellular space, ATP is inherently short-lived molecule, which undergoes rapid enzymatic degradation to adenosine by ectonucleotidases. Given that ectonucleotidases have distinct and overlapping distribution in the hippocampus, and as ovarian hormones participate in a formation, maturation, and a refinement of synaptic contacts, both during development and in adulthood, the present chapter summarizes known data about spatial distribution of selected ecto-enzymes and estradiol-induced effects on ectonucleotidases in the rat hippocampus.",
journal = "Vitamins and Hormones",
booktitle = "Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement",
volume = "118",
pages = "199-221",
doi = "10.1016/bs.vh.2021.11.005"
}

Grković, I., Mitrović, N. Lj.,& Dragić, M.. (2021). Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement. in Vitamins and Hormones, 118, 199-221.
https://doi.org/10.1016/bs.vh.2021.11.005

Grković I, Mitrović NL, Dragić M. Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement. in Vitamins and Hormones. 2021;118:199-221.
doi:10.1016/bs.vh.2021.11.005 .

Grković, Ivana, Mitrović, Nataša Lj., Dragić, Milorad, "Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement" in Vitamins and Hormones, 118 (2021):199-221,
https://doi.org/10.1016/bs.vh.2021.11.005 . .

TY  - JOUR
AU  - Brkić, Željka
AU  - Živanović, Ana
AU  - Adžić, Miroslav
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9739
AB  - Mitochondria play a significant role in pathogenesis of clinical depression and their function can be impaired by inflammation and alterations in hypothalamic–pituitary–adrenal axis. Sexual context is also a relevant factor in the incidence of mood disorders, and could have a strong influence during an immune challenge. Therefore, in this study we investigated whether the effects of seven-day lipopolysaccharide (LPS) treatment on glucocorticoid receptor (GR) could be associated with apoptosis and alterations in energy metabolism in hippocampus of female and male Wistar rats with depressive-like behavior. To that end, we measured the mitochondrial levels of GR and its phosphoisoforms pGR232 and pGR246 in hippocampus of female and male rats, as well as the mRNA levels of two GR-regulated mitochondrial genes, cyclooxygenase -1 and -3 (COX-1 and -3). We also measured alterations in the extrinsic and intrinsic apoptotic pathways in mitochondria and cytosol of hippocampus of these animals, and the levels of cleaved cytosolic poly [ADP-ribose] polymerase-1 (PARP-1) protein. We discovered that even though LPS treatment induced behavioral alterations and affected corticosterone levels and apoptosis in a similar manner in both sexes, it affected mitochondrial GR differently in males and females. Namely, the treatment decreased levels of mitochondrial GR and pGR232/pGR246 ratio only in females, and these alterations were followed by decreased mRNA levels of COX-1 and COX-3 only in this sex. The alterations in COX-1 and COX-3 mRNA levels could indicate impaired oxidative metabolism and diminished mitochondrial function in hippocampus of this sex. © 2020 IBRO
T2  - Neuroscience
T1  - Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression
VL  - 451
SP  - 174
EP  - 183
DO  - 10.1016/j.neuroscience.2020.09.059
ER  - 

@article{
author = "Brkić, Željka and Živanović, Ana and Adžić, Miroslav",
year = "2020",
abstract = "Mitochondria play a significant role in pathogenesis of clinical depression and their function can be impaired by inflammation and alterations in hypothalamic–pituitary–adrenal axis. Sexual context is also a relevant factor in the incidence of mood disorders, and could have a strong influence during an immune challenge. Therefore, in this study we investigated whether the effects of seven-day lipopolysaccharide (LPS) treatment on glucocorticoid receptor (GR) could be associated with apoptosis and alterations in energy metabolism in hippocampus of female and male Wistar rats with depressive-like behavior. To that end, we measured the mitochondrial levels of GR and its phosphoisoforms pGR232 and pGR246 in hippocampus of female and male rats, as well as the mRNA levels of two GR-regulated mitochondrial genes, cyclooxygenase -1 and -3 (COX-1 and -3). We also measured alterations in the extrinsic and intrinsic apoptotic pathways in mitochondria and cytosol of hippocampus of these animals, and the levels of cleaved cytosolic poly [ADP-ribose] polymerase-1 (PARP-1) protein. We discovered that even though LPS treatment induced behavioral alterations and affected corticosterone levels and apoptosis in a similar manner in both sexes, it affected mitochondrial GR differently in males and females. Namely, the treatment decreased levels of mitochondrial GR and pGR232/pGR246 ratio only in females, and these alterations were followed by decreased mRNA levels of COX-1 and COX-3 only in this sex. The alterations in COX-1 and COX-3 mRNA levels could indicate impaired oxidative metabolism and diminished mitochondrial function in hippocampus of this sex. © 2020 IBRO",
journal = "Neuroscience",
title = "Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression",
volume = "451",
pages = "174-183",
doi = "10.1016/j.neuroscience.2020.09.059"
}

Brkić, Ž., Živanović, A.,& Adžić, M.. (2020). Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression. in Neuroscience, 451, 174-183.
https://doi.org/10.1016/j.neuroscience.2020.09.059

Brkić Ž, Živanović A, Adžić M. Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression. in Neuroscience. 2020;451:174-183.
doi:10.1016/j.neuroscience.2020.09.059 .

Brkić, Željka, Živanović, Ana, Adžić, Miroslav, "Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression" in Neuroscience, 451 (2020):174-183,
https://doi.org/10.1016/j.neuroscience.2020.09.059 . .