Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement
Апстракт
Extracellular purine nucleotides, such as adenosine 5′-triphosphate (ATP), are important modulators of hippocampal function and plasticity. In the extracellular space, ATP is inherently short-lived molecule, which undergoes rapid enzymatic degradation to adenosine by ectonucleotidases. Given that ectonucleotidases have distinct and overlapping distribution in the hippocampus, and as ovarian hormones participate in a formation, maturation, and a refinement of synaptic contacts, both during development and in adulthood, the present chapter summarizes known data about spatial distribution of selected ecto-enzymes and estradiol-induced effects on ectonucleotidases in the rat hippocampus.
Кључне речи:
Adenosine / Ecto-5′nucleotidase / Ectonucleotidases / Estradiol / Hippocampus / NTPDase / Purinergic signaling / Synaptic modulationИзвор:
Vitamins and Hormones, 2021, 118, 199-221Финансирање / пројекти:
- Ministry of Education, Science and Technological Development, Republic of Serbia
DOI: 10.1016/bs.vh.2021.11.005
ISBN: 978-032399221-3
ISSN: 0083-6729
PubMed: 35180927
Scopus: 2-s2.0-85121273432
Институција/група
VinčaTY - CHAP AU - Grković, Ivana AU - Mitrović, Nataša Lj. AU - Dragić, Milorad PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10095 AB - Extracellular purine nucleotides, such as adenosine 5′-triphosphate (ATP), are important modulators of hippocampal function and plasticity. In the extracellular space, ATP is inherently short-lived molecule, which undergoes rapid enzymatic degradation to adenosine by ectonucleotidases. Given that ectonucleotidases have distinct and overlapping distribution in the hippocampus, and as ovarian hormones participate in a formation, maturation, and a refinement of synaptic contacts, both during development and in adulthood, the present chapter summarizes known data about spatial distribution of selected ecto-enzymes and estradiol-induced effects on ectonucleotidases in the rat hippocampus. T2 - Vitamins and Hormones T1 - Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement VL - 118 SP - 199 EP - 221 DO - 10.1016/bs.vh.2021.11.005 ER -
@inbook{ author = "Grković, Ivana and Mitrović, Nataša Lj. and Dragić, Milorad", year = "2021", abstract = "Extracellular purine nucleotides, such as adenosine 5′-triphosphate (ATP), are important modulators of hippocampal function and plasticity. In the extracellular space, ATP is inherently short-lived molecule, which undergoes rapid enzymatic degradation to adenosine by ectonucleotidases. Given that ectonucleotidases have distinct and overlapping distribution in the hippocampus, and as ovarian hormones participate in a formation, maturation, and a refinement of synaptic contacts, both during development and in adulthood, the present chapter summarizes known data about spatial distribution of selected ecto-enzymes and estradiol-induced effects on ectonucleotidases in the rat hippocampus.", journal = "Vitamins and Hormones", booktitle = "Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement", volume = "118", pages = "199-221", doi = "10.1016/bs.vh.2021.11.005" }
Grković, I., Mitrović, N. Lj.,& Dragić, M.. (2021). Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement. in Vitamins and Hormones, 118, 199-221. https://doi.org/10.1016/bs.vh.2021.11.005
Grković I, Mitrović NL, Dragić M. Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement. in Vitamins and Hormones. 2021;118:199-221. doi:10.1016/bs.vh.2021.11.005 .
Grković, Ivana, Mitrović, Nataša Lj., Dragić, Milorad, "Ectonucleotidases in the hippocampus: Spatial distribution and expression after ovariectomy and estradiol replacement" in Vitamins and Hormones, 118 (2021):199-221, https://doi.org/10.1016/bs.vh.2021.11.005 . .