TY  - JOUR
AU  - Dinčić, Dragan
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
AU  - Vujanic, S
AU  - Gligic, B
AU  - Alavantić, Dragan
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2907
AB  - Objectives: Lipoprotein(a) (Lp(a)) concentration is determined primarily by the apolipoprotein(a) (apo(a)) gene. The pentanucleotide (TTTTA)n repeat and G/A-914 polymorphisms are in the 5 promoter region of the apo(a) gene. To elucidate whether these polymorphisms affect Lp(a) levels, a total of 211 Serbian adults were investigated. esign: One hundred and eleven patients with ischemic heart disease and 100 healthy controls were genotyped and Lp(a) levels determined. Results: Lp(a) concentrations differed according to the (TTTTA)n genotypes: among those having at least one allele 8, patients had significantly higher Lp(a) values than controls. A decreasing trend of Lp(a) values was associated with the -914A allele in controls but the opposite was true in patients. Patients with genotype TTTTA allele 8/AA-914 had significantly higher Lp(a) values than those without allele 8/AA (p LT 0.05). The GT 8 GT 8/GG genotype was not detected. Significant linkage disequilibrium between (TTTTA)n and G/A-914 polymorphism (p LT 0.001) was found. In multivariate regression analysis, the G/A-914 polymorphism significantly (p LT 0.05) affected Lp(a) levels in patients, after taking into account the (TTTTA)n polymorphism. Conclusion: These results indicate that (TTTTA)n and G/A-914 polymorphisms affect Lp(a) levels in ischemic heart disease as a consequence of the linkage disequlibnum.
T2  - Wiener Klinische Wochenschrift
T1  - Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia
VL  - 117
IS  - 11-12
SP  - 406
EP  - 411
DO  - 10.1007/s00508-005-0358-3
ER  - 

@article{
author = "Dinčić, Dragan and Živković, Maja and Stanković, Aleksandra and Đurić, Tamara and Vujanic, S and Gligic, B and Alavantić, Dragan",
year = "2005",
abstract = "Objectives: Lipoprotein(a) (Lp(a)) concentration is determined primarily by the apolipoprotein(a) (apo(a)) gene. The pentanucleotide (TTTTA)n repeat and G/A-914 polymorphisms are in the 5 promoter region of the apo(a) gene. To elucidate whether these polymorphisms affect Lp(a) levels, a total of 211 Serbian adults were investigated. esign: One hundred and eleven patients with ischemic heart disease and 100 healthy controls were genotyped and Lp(a) levels determined. Results: Lp(a) concentrations differed according to the (TTTTA)n genotypes: among those having at least one allele 8, patients had significantly higher Lp(a) values than controls. A decreasing trend of Lp(a) values was associated with the -914A allele in controls but the opposite was true in patients. Patients with genotype TTTTA allele 8/AA-914 had significantly higher Lp(a) values than those without allele 8/AA (p LT 0.05). The GT 8 GT 8/GG genotype was not detected. Significant linkage disequilibrium between (TTTTA)n and G/A-914 polymorphism (p LT 0.001) was found. In multivariate regression analysis, the G/A-914 polymorphism significantly (p LT 0.05) affected Lp(a) levels in patients, after taking into account the (TTTTA)n polymorphism. Conclusion: These results indicate that (TTTTA)n and G/A-914 polymorphisms affect Lp(a) levels in ischemic heart disease as a consequence of the linkage disequlibnum.",
journal = "Wiener Klinische Wochenschrift",
title = "Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia",
volume = "117",
number = "11-12",
pages = "406-411",
doi = "10.1007/s00508-005-0358-3"
}

Dinčić, D., Živković, M., Stanković, A., Đurić, T., Vujanic, S., Gligic, B.,& Alavantić, D.. (2005). Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia. in Wiener Klinische Wochenschrift, 117(11-12), 406-411.
https://doi.org/10.1007/s00508-005-0358-3

Dinčić D, Živković M, Stanković A, Đurić T, Vujanic S, Gligic B, Alavantić D. Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia. in Wiener Klinische Wochenschrift. 2005;117(11-12):406-411.
doi:10.1007/s00508-005-0358-3 .

Dinčić, Dragan, Živković, Maja, Stanković, Aleksandra, Đurić, Tamara, Vujanic, S, Gligic, B, Alavantić, Dragan, "Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia" in Wiener Klinische Wochenschrift, 117, no. 11-12 (2005):406-411,
https://doi.org/10.1007/s00508-005-0358-3 . .