Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia
Нема приказа
Аутори
Dinčić, DraganŽivković, Maja
Stanković, Aleksandra
Đurić, Tamara
Vujanic, S
Gligic, B
Alavantić, Dragan
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Objectives: Lipoprotein(a) (Lp(a)) concentration is determined primarily by the apolipoprotein(a) (apo(a)) gene. The pentanucleotide (TTTTA)n repeat and G/A-914 polymorphisms are in the 5 promoter region of the apo(a) gene. To elucidate whether these polymorphisms affect Lp(a) levels, a total of 211 Serbian adults were investigated. esign: One hundred and eleven patients with ischemic heart disease and 100 healthy controls were genotyped and Lp(a) levels determined. Results: Lp(a) concentrations differed according to the (TTTTA)n genotypes: among those having at least one allele 8, patients had significantly higher Lp(a) values than controls. A decreasing trend of Lp(a) values was associated with the -914A allele in controls but the opposite was true in patients. Patients with genotype TTTTA allele 8/AA-914 had significantly higher Lp(a) values than those without allele 8/AA (p LT 0.05). The GT 8 GT 8/GG genotype was not detected. Significant linkage disequilibrium between (TTTTA)n and... G/A-914 polymorphism (p LT 0.001) was found. In multivariate regression analysis, the G/A-914 polymorphism significantly (p LT 0.05) affected Lp(a) levels in patients, after taking into account the (TTTTA)n polymorphism. Conclusion: These results indicate that (TTTTA)n and G/A-914 polymorphisms affect Lp(a) levels in ischemic heart disease as a consequence of the linkage disequlibnum.
Кључне речи:
Apolipoprotein(a) / G/A-914 / gene polymorphism / ischemic heart disease / lipoprotein(a) / (TTTTA)nИзвор:
Wiener Klinische Wochenschrift, 2005, 117, 11-12, 406-411
DOI: 10.1007/s00508-005-0358-3
ISSN: 0043-5325
PubMed: 16053196
WoS: 000230678000007
Scopus: 2-s2.0-23844448381
Колекције
Институција/група
VinčaTY - JOUR AU - Dinčić, Dragan AU - Živković, Maja AU - Stanković, Aleksandra AU - Đurić, Tamara AU - Vujanic, S AU - Gligic, B AU - Alavantić, Dragan PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2907 AB - Objectives: Lipoprotein(a) (Lp(a)) concentration is determined primarily by the apolipoprotein(a) (apo(a)) gene. The pentanucleotide (TTTTA)n repeat and G/A-914 polymorphisms are in the 5 promoter region of the apo(a) gene. To elucidate whether these polymorphisms affect Lp(a) levels, a total of 211 Serbian adults were investigated. esign: One hundred and eleven patients with ischemic heart disease and 100 healthy controls were genotyped and Lp(a) levels determined. Results: Lp(a) concentrations differed according to the (TTTTA)n genotypes: among those having at least one allele 8, patients had significantly higher Lp(a) values than controls. A decreasing trend of Lp(a) values was associated with the -914A allele in controls but the opposite was true in patients. Patients with genotype TTTTA allele 8/AA-914 had significantly higher Lp(a) values than those without allele 8/AA (p LT 0.05). The GT 8 GT 8/GG genotype was not detected. Significant linkage disequilibrium between (TTTTA)n and G/A-914 polymorphism (p LT 0.001) was found. In multivariate regression analysis, the G/A-914 polymorphism significantly (p LT 0.05) affected Lp(a) levels in patients, after taking into account the (TTTTA)n polymorphism. Conclusion: These results indicate that (TTTTA)n and G/A-914 polymorphisms affect Lp(a) levels in ischemic heart disease as a consequence of the linkage disequlibnum. T2 - Wiener Klinische Wochenschrift T1 - Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia VL - 117 IS - 11-12 SP - 406 EP - 411 DO - 10.1007/s00508-005-0358-3 ER -
@article{ author = "Dinčić, Dragan and Živković, Maja and Stanković, Aleksandra and Đurić, Tamara and Vujanic, S and Gligic, B and Alavantić, Dragan", year = "2005", abstract = "Objectives: Lipoprotein(a) (Lp(a)) concentration is determined primarily by the apolipoprotein(a) (apo(a)) gene. The pentanucleotide (TTTTA)n repeat and G/A-914 polymorphisms are in the 5 promoter region of the apo(a) gene. To elucidate whether these polymorphisms affect Lp(a) levels, a total of 211 Serbian adults were investigated. esign: One hundred and eleven patients with ischemic heart disease and 100 healthy controls were genotyped and Lp(a) levels determined. Results: Lp(a) concentrations differed according to the (TTTTA)n genotypes: among those having at least one allele 8, patients had significantly higher Lp(a) values than controls. A decreasing trend of Lp(a) values was associated with the -914A allele in controls but the opposite was true in patients. Patients with genotype TTTTA allele 8/AA-914 had significantly higher Lp(a) values than those without allele 8/AA (p LT 0.05). The GT 8 GT 8/GG genotype was not detected. Significant linkage disequilibrium between (TTTTA)n and G/A-914 polymorphism (p LT 0.001) was found. In multivariate regression analysis, the G/A-914 polymorphism significantly (p LT 0.05) affected Lp(a) levels in patients, after taking into account the (TTTTA)n polymorphism. Conclusion: These results indicate that (TTTTA)n and G/A-914 polymorphisms affect Lp(a) levels in ischemic heart disease as a consequence of the linkage disequlibnum.", journal = "Wiener Klinische Wochenschrift", title = "Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia", volume = "117", number = "11-12", pages = "406-411", doi = "10.1007/s00508-005-0358-3" }
Dinčić, D., Živković, M., Stanković, A., Đurić, T., Vujanic, S., Gligic, B.,& Alavantić, D.. (2005). Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia. in Wiener Klinische Wochenschrift, 117(11-12), 406-411. https://doi.org/10.1007/s00508-005-0358-3
Dinčić D, Živković M, Stanković A, Đurić T, Vujanic S, Gligic B, Alavantić D. Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia. in Wiener Klinische Wochenschrift. 2005;117(11-12):406-411. doi:10.1007/s00508-005-0358-3 .
Dinčić, Dragan, Živković, Maja, Stanković, Aleksandra, Đurić, Tamara, Vujanic, S, Gligic, B, Alavantić, Dragan, "Apolipoprotein(a) gene polymorphisms (TTTTA)(n) and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia" in Wiener Klinische Wochenschrift, 117, no. 11-12 (2005):406-411, https://doi.org/10.1007/s00508-005-0358-3 . .