TY  - CONF
AU  - Tijanić, A.
AU  - Ristić, T.
AU  - Habach, T.
AU  - Milenković, B.
AU  - Drakulić, Dunja R.
AU  - Pejić, Snežana
AU  - Stanković, S.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12858
AB  - BACKGROUND-AIM Invasive mechanical ventilation (IMV) is frequently needed intervention in patients with severe COVID19. There areattempts to identify biomarkers that could be helpful in determining the best moment to intubate these patients.It is known that cost-effective hematological indices, easily calculated from a routine complete blood count (CBC),are useful in determining patient's inflammatory response to COVID-19. The aim of this study was to examine thehematologic indices value in patients with and without the need for IMV and a control group.METHODS A total of 274 COVID-19 patients (178 males/96 females, median age 65), hospitalized in temporary COVID-19 hospitalin Clinic for Pulmonology Diseases, University Clinical Centre of Serbia in Belgrade between November 18, 2020 toJanuary 15, 2021, were stratified as IMV (Group 1) (n = 24) or did not require invasive mechanical ventilation (Group2) (n = 250). The control group was consisted of 274 healthy individuals. CBC was determined at hospital admissionusing Sysmex XN-1000 (Sysmex Corporation, Kobe, Japan). Few hematologic indices were calculated, the neutrophil-to-lymphocyte ratio (NLR), the derived NLR (d-NLR), the neutrophil-to-platelet ratio (NPR), the platelet-to-lymphocyteratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). RESULTS There was significant differences (p<0.001) in all hematological ratios between COVID-19 patients and the controlgroup. Patients in Group 1 had significantly higher values of NLR (7.1 (3.3-15.7) vs 4.3 (2.4-8.1), p = 0.011), dNLR (4.4(2.5-8.3) vs 2.8 (1.7-5.1), p = 0.013), NPR (0.03 (0.02-0.05) vs 0.02 (0.01-0.03), p = 0.001), compared to those in group 2.Conversely, the Group 1 had markedly decreased LMR (1.9 (1.1-3.3) vs 2.5 (1.8-3.7), p = 0.043), compared to the Group2. There was no significant difference in PLR and SII between these two groups (p >0.05). CONCLUSIONS Our study suggests that admission value of hematological indices NLR, dNLR, NPR have potential for use as auxiliaries in clinical decision-making regarding the need for IMV in COVID-19 patients.
PB  - Berlin ; Boston : Walter de Gruyter
C3  - Clinical chemistry and laboratory medicine
T1  - Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation
VL  - 61
IS  - Special Supplement
SP  - S770
EP  - S770
DO  - 10.1515/cclm-2023-7041
ER  - 

@conference{
author = "Tijanić, A. and Ristić, T. and Habach, T. and Milenković, B. and Drakulić, Dunja R. and Pejić, Snežana and Stanković, S.",
year = "2023",
abstract = "BACKGROUND-AIM Invasive mechanical ventilation (IMV) is frequently needed intervention in patients with severe COVID19. There areattempts to identify biomarkers that could be helpful in determining the best moment to intubate these patients.It is known that cost-effective hematological indices, easily calculated from a routine complete blood count (CBC),are useful in determining patient's inflammatory response to COVID-19. The aim of this study was to examine thehematologic indices value in patients with and without the need for IMV and a control group.METHODS A total of 274 COVID-19 patients (178 males/96 females, median age 65), hospitalized in temporary COVID-19 hospitalin Clinic for Pulmonology Diseases, University Clinical Centre of Serbia in Belgrade between November 18, 2020 toJanuary 15, 2021, were stratified as IMV (Group 1) (n = 24) or did not require invasive mechanical ventilation (Group2) (n = 250). The control group was consisted of 274 healthy individuals. CBC was determined at hospital admissionusing Sysmex XN-1000 (Sysmex Corporation, Kobe, Japan). Few hematologic indices were calculated, the neutrophil-to-lymphocyte ratio (NLR), the derived NLR (d-NLR), the neutrophil-to-platelet ratio (NPR), the platelet-to-lymphocyteratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). RESULTS There was significant differences (p<0.001) in all hematological ratios between COVID-19 patients and the controlgroup. Patients in Group 1 had significantly higher values of NLR (7.1 (3.3-15.7) vs 4.3 (2.4-8.1), p = 0.011), dNLR (4.4(2.5-8.3) vs 2.8 (1.7-5.1), p = 0.013), NPR (0.03 (0.02-0.05) vs 0.02 (0.01-0.03), p = 0.001), compared to those in group 2.Conversely, the Group 1 had markedly decreased LMR (1.9 (1.1-3.3) vs 2.5 (1.8-3.7), p = 0.043), compared to the Group2. There was no significant difference in PLR and SII between these two groups (p >0.05). CONCLUSIONS Our study suggests that admission value of hematological indices NLR, dNLR, NPR have potential for use as auxiliaries in clinical decision-making regarding the need for IMV in COVID-19 patients.",
publisher = "Berlin ; Boston : Walter de Gruyter",
journal = "Clinical chemistry and laboratory medicine",
title = "Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation",
volume = "61",
number = "Special Supplement",
pages = "S770-S770",
doi = "10.1515/cclm-2023-7041"
}

Tijanić, A., Ristić, T., Habach, T., Milenković, B., Drakulić, D. R., Pejić, S.,& Stanković, S.. (2023). Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation. in Clinical chemistry and laboratory medicine
Berlin ; Boston : Walter de Gruyter., 61(Special Supplement), S770-S770.
https://doi.org/10.1515/cclm-2023-7041

Tijanić A, Ristić T, Habach T, Milenković B, Drakulić DR, Pejić S, Stanković S. Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation. in Clinical chemistry and laboratory medicine. 2023;61(Special Supplement):S770-S770.
doi:10.1515/cclm-2023-7041 .

Tijanić, A., Ristić, T., Habach, T., Milenković, B., Drakulić, Dunja R., Pejić, Snežana, Stanković, S., "Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation" in Clinical chemistry and laboratory medicine, 61, no. Special Supplement (2023):S770-S770,
https://doi.org/10.1515/cclm-2023-7041 . .