Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation
Само за регистроване кориснике
2023
Аутори
Tijanić, A.Ristić, T.
Habach, T.
Milenković, B.
Drakulić, Dunja R.
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Pejić, Snežana
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Stanković, S.
Конференцијски прилог (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
BACKGROUND-AIM Invasive mechanical ventilation (IMV) is frequently needed intervention in patients with severe COVID19. There areattempts to identify biomarkers that could be helpful in determining the best moment to intubate these patients.It is known that cost-effective hematological indices, easily calculated from a routine complete blood count (CBC),are useful in determining patient's inflammatory response to COVID-19. The aim of this study was to examine thehematologic indices value in patients with and without the need for IMV and a control group.METHODS A total of 274 COVID-19 patients (178 males/96 females, median age 65), hospitalized in temporary COVID-19 hospitalin Clinic for Pulmonology Diseases, University Clinical Centre of Serbia in Belgrade between November 18, 2020 toJanuary 15, 2021, were stratified as IMV (Group 1) (n = 24) or did not require invasive mechanical ventilation (Group2) (n = 250). The control group was consisted of 274 healthy individuals. CBC was determ...ined at hospital admissionusing Sysmex XN-1000 (Sysmex Corporation, Kobe, Japan). Few hematologic indices were calculated, the neutrophil-to-lymphocyte ratio (NLR), the derived NLR (d-NLR), the neutrophil-to-platelet ratio (NPR), the platelet-to-lymphocyteratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). RESULTS There was significant differences (p<0.001) in all hematological ratios between COVID-19 patients and the controlgroup. Patients in Group 1 had significantly higher values of NLR (7.1 (3.3-15.7) vs 4.3 (2.4-8.1), p = 0.011), dNLR (4.4(2.5-8.3) vs 2.8 (1.7-5.1), p = 0.013), NPR (0.03 (0.02-0.05) vs 0.02 (0.01-0.03), p = 0.001), compared to those in group 2.Conversely, the Group 1 had markedly decreased LMR (1.9 (1.1-3.3) vs 2.5 (1.8-3.7), p = 0.043), compared to the Group2. There was no significant difference in PLR and SII between these two groups (p >0.05). CONCLUSIONS Our study suggests that admission value of hematological indices NLR, dNLR, NPR have potential for use as auxiliaries in clinical decision-making regarding the need for IMV in COVID-19 patients.
Извор:
Clinical chemistry and laboratory medicine, 2023, 61, Special Supplement, S770-S770Издавач:
- Berlin ; Boston : Walter de Gruyter
Напомена:
- 25th International congress of Clinical Chemistry and Laboratory Medicine, Poster Abstracts - WorldLab.EuroMedLab Roma 2023 – Rome, Italy, May 21-25, 2023
Колекције
Институција/група
VinčaTY - CONF AU - Tijanić, A. AU - Ristić, T. AU - Habach, T. AU - Milenković, B. AU - Drakulić, Dunja R. AU - Pejić, Snežana AU - Stanković, S. PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12858 AB - BACKGROUND-AIM Invasive mechanical ventilation (IMV) is frequently needed intervention in patients with severe COVID19. There areattempts to identify biomarkers that could be helpful in determining the best moment to intubate these patients.It is known that cost-effective hematological indices, easily calculated from a routine complete blood count (CBC),are useful in determining patient's inflammatory response to COVID-19. The aim of this study was to examine thehematologic indices value in patients with and without the need for IMV and a control group.METHODS A total of 274 COVID-19 patients (178 males/96 females, median age 65), hospitalized in temporary COVID-19 hospitalin Clinic for Pulmonology Diseases, University Clinical Centre of Serbia in Belgrade between November 18, 2020 toJanuary 15, 2021, were stratified as IMV (Group 1) (n = 24) or did not require invasive mechanical ventilation (Group2) (n = 250). The control group was consisted of 274 healthy individuals. CBC was determined at hospital admissionusing Sysmex XN-1000 (Sysmex Corporation, Kobe, Japan). Few hematologic indices were calculated, the neutrophil-to-lymphocyte ratio (NLR), the derived NLR (d-NLR), the neutrophil-to-platelet ratio (NPR), the platelet-to-lymphocyteratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). RESULTS There was significant differences (p<0.001) in all hematological ratios between COVID-19 patients and the controlgroup. Patients in Group 1 had significantly higher values of NLR (7.1 (3.3-15.7) vs 4.3 (2.4-8.1), p = 0.011), dNLR (4.4(2.5-8.3) vs 2.8 (1.7-5.1), p = 0.013), NPR (0.03 (0.02-0.05) vs 0.02 (0.01-0.03), p = 0.001), compared to those in group 2.Conversely, the Group 1 had markedly decreased LMR (1.9 (1.1-3.3) vs 2.5 (1.8-3.7), p = 0.043), compared to the Group2. There was no significant difference in PLR and SII between these two groups (p >0.05). CONCLUSIONS Our study suggests that admission value of hematological indices NLR, dNLR, NPR have potential for use as auxiliaries in clinical decision-making regarding the need for IMV in COVID-19 patients. PB - Berlin ; Boston : Walter de Gruyter C3 - Clinical chemistry and laboratory medicine T1 - Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation VL - 61 IS - Special Supplement SP - S770 EP - S770 DO - 10.1515/cclm-2023-7041 ER -
@conference{ author = "Tijanić, A. and Ristić, T. and Habach, T. and Milenković, B. and Drakulić, Dunja R. and Pejić, Snežana and Stanković, S.", year = "2023", abstract = "BACKGROUND-AIM Invasive mechanical ventilation (IMV) is frequently needed intervention in patients with severe COVID19. There areattempts to identify biomarkers that could be helpful in determining the best moment to intubate these patients.It is known that cost-effective hematological indices, easily calculated from a routine complete blood count (CBC),are useful in determining patient's inflammatory response to COVID-19. The aim of this study was to examine thehematologic indices value in patients with and without the need for IMV and a control group.METHODS A total of 274 COVID-19 patients (178 males/96 females, median age 65), hospitalized in temporary COVID-19 hospitalin Clinic for Pulmonology Diseases, University Clinical Centre of Serbia in Belgrade between November 18, 2020 toJanuary 15, 2021, were stratified as IMV (Group 1) (n = 24) or did not require invasive mechanical ventilation (Group2) (n = 250). The control group was consisted of 274 healthy individuals. CBC was determined at hospital admissionusing Sysmex XN-1000 (Sysmex Corporation, Kobe, Japan). Few hematologic indices were calculated, the neutrophil-to-lymphocyte ratio (NLR), the derived NLR (d-NLR), the neutrophil-to-platelet ratio (NPR), the platelet-to-lymphocyteratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). RESULTS There was significant differences (p<0.001) in all hematological ratios between COVID-19 patients and the controlgroup. Patients in Group 1 had significantly higher values of NLR (7.1 (3.3-15.7) vs 4.3 (2.4-8.1), p = 0.011), dNLR (4.4(2.5-8.3) vs 2.8 (1.7-5.1), p = 0.013), NPR (0.03 (0.02-0.05) vs 0.02 (0.01-0.03), p = 0.001), compared to those in group 2.Conversely, the Group 1 had markedly decreased LMR (1.9 (1.1-3.3) vs 2.5 (1.8-3.7), p = 0.043), compared to the Group2. There was no significant difference in PLR and SII between these two groups (p >0.05). CONCLUSIONS Our study suggests that admission value of hematological indices NLR, dNLR, NPR have potential for use as auxiliaries in clinical decision-making regarding the need for IMV in COVID-19 patients.", publisher = "Berlin ; Boston : Walter de Gruyter", journal = "Clinical chemistry and laboratory medicine", title = "Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation", volume = "61", number = "Special Supplement", pages = "S770-S770", doi = "10.1515/cclm-2023-7041" }
Tijanić, A., Ristić, T., Habach, T., Milenković, B., Drakulić, D. R., Pejić, S.,& Stanković, S.. (2023). Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation. in Clinical chemistry and laboratory medicine Berlin ; Boston : Walter de Gruyter., 61(Special Supplement), S770-S770. https://doi.org/10.1515/cclm-2023-7041
Tijanić A, Ristić T, Habach T, Milenković B, Drakulić DR, Pejić S, Stanković S. Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation. in Clinical chemistry and laboratory medicine. 2023;61(Special Supplement):S770-S770. doi:10.1515/cclm-2023-7041 .
Tijanić, A., Ristić, T., Habach, T., Milenković, B., Drakulić, Dunja R., Pejić, Snežana, Stanković, S., "Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation" in Clinical chemistry and laboratory medicine, 61, no. Special Supplement (2023):S770-S770, https://doi.org/10.1515/cclm-2023-7041 . .