TY  - CONF
AU  - Keta, Otilija D.
AU  - Bulat, Tanja M.
AU  - Korićanac, Lela
AU  - Todorović, Dragana
AU  - Privitera, G.
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9300
AB  - In order to increase radio-sensitivity of human lung adenocarcinoma NCI-H1568
cells, targeted therapy drug, erlotinib was used. The impact of radiation and
erlotinib on cell behaviour was analyzed using three biological endpoints.
Irradiations with γ-rays resulted in reduction of cell survival, viability and
proliferation. Erlotinib significantly inhibited cell growth and proliferation
capacity. Combined treatments with radiation and erlotinib showed high level of
reduction of cell viability and proliferation. Preliminary data encourage further
investigations of mechanisms underlying the radiation responses enhanced by
erlotinib.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
T1  - Sensitivity of Lung Carcinoma Cells to γ-rays and Erlotinib
VL  - 1
SP  - 382
EP  - 384
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9300
ER  - 

@conference{
author = "Keta, Otilija D. and Bulat, Tanja M. and Korićanac, Lela and Todorović, Dragana and Privitera, G. and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2012",
abstract = "In order to increase radio-sensitivity of human lung adenocarcinoma NCI-H1568
cells, targeted therapy drug, erlotinib was used. The impact of radiation and
erlotinib on cell behaviour was analyzed using three biological endpoints.
Irradiations with γ-rays resulted in reduction of cell survival, viability and
proliferation. Erlotinib significantly inhibited cell growth and proliferation
capacity. Combined treatments with radiation and erlotinib showed high level of
reduction of cell viability and proliferation. Preliminary data encourage further
investigations of mechanisms underlying the radiation responses enhanced by
erlotinib.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry",
title = "Sensitivity of Lung Carcinoma Cells to γ-rays and Erlotinib",
volume = "1",
pages = "382-384",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9300"
}

Keta, O. D., Bulat, T. M., Korićanac, L., Todorović, D., Privitera, G., Petrović, I. M.,& Ristić-Fira, A.. (2012). Sensitivity of Lung Carcinoma Cells to γ-rays and Erlotinib. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 382-384.
https://hdl.handle.net/21.15107/rcub_vinar_9300

Keta OD, Bulat TM, Korićanac L, Todorović D, Privitera G, Petrović IM, Ristić-Fira A. Sensitivity of Lung Carcinoma Cells to γ-rays and Erlotinib. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;1:382-384.
https://hdl.handle.net/21.15107/rcub_vinar_9300 .

Keta, Otilija D., Bulat, Tanja M., Korićanac, Lela, Todorović, Dragana, Privitera, G., Petrović, Ivan M., Ristić-Fira, Aleksandra, "Sensitivity of Lung Carcinoma Cells to γ-rays and Erlotinib" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 1 (2012):382-384,
https://hdl.handle.net/21.15107/rcub_vinar_9300 .

TY  - JOUR
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Keta, Otilija D.
AU  - Privitera G.
AU  - Cirrone, G. A. P.
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10506
AB  - Deregulation of apoptosis commonly occurs in melanoma cells and could be a reason for resistance. The effectiveness of different treatments depends on their ability to activate this process. In this study the effects of combined treatments with fotemustine (FM) and proton irradiation on the regulators of apoptosis were analyzed. Sub-confluent HTB140 human melanoma cells were treated with FM (100, 250 µM) 24 h prior to irradiation (12, 16 Gy). Cells were irradiated in the middle of the therapeutic 62 MeV proton spread out Bragg peak. Flow cytometric analysis of apoptosis and the Western blot analysis of apoptotic regulators were performed 6 or 48 h after treatments. Percent of apoptotic nuclei increased after applied treatments, reaching the level of 4 to 41 %. Induction of apoptosis was associated with p53 and Bax up regulation and Bcl-2 down regulation. The obtained results imply that analyzed treatments induce apoptosis through the activation of the mitochondrial apoptotic pathway, with better pro-apoptotic effects achieved by combined treatments.
T2  - INFN-LNS Activity report 2009
T1  - Alteration of p53 and Bax/ Bcl-2 ratio by fotemustine and proton irradiation
SP  - 234
EP  - 237
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10506
ER  - 

@article{
author = "Korićanac, Lela and Žakula, Jelena and Keta, Otilija D. and Privitera G. and Cirrone, G. A. P. and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2010",
abstract = "Deregulation of apoptosis commonly occurs in melanoma cells and could be a reason for resistance. The effectiveness of different treatments depends on their ability to activate this process. In this study the effects of combined treatments with fotemustine (FM) and proton irradiation on the regulators of apoptosis were analyzed. Sub-confluent HTB140 human melanoma cells were treated with FM (100, 250 µM) 24 h prior to irradiation (12, 16 Gy). Cells were irradiated in the middle of the therapeutic 62 MeV proton spread out Bragg peak. Flow cytometric analysis of apoptosis and the Western blot analysis of apoptotic regulators were performed 6 or 48 h after treatments. Percent of apoptotic nuclei increased after applied treatments, reaching the level of 4 to 41 %. Induction of apoptosis was associated with p53 and Bax up regulation and Bcl-2 down regulation. The obtained results imply that analyzed treatments induce apoptosis through the activation of the mitochondrial apoptotic pathway, with better pro-apoptotic effects achieved by combined treatments.",
journal = "INFN-LNS Activity report 2009",
title = "Alteration of p53 and Bax/ Bcl-2 ratio by fotemustine and proton irradiation",
pages = "234-237",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10506"
}

Korićanac, L., Žakula, J., Keta, O. D., Privitera G., Cirrone, G. A. P., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2010). Alteration of p53 and Bax/ Bcl-2 ratio by fotemustine and proton irradiation. in INFN-LNS Activity report 2009, 234-237.
https://hdl.handle.net/21.15107/rcub_vinar_10506

Korićanac L, Žakula J, Keta OD, Privitera G., Cirrone GAP, Cuttone G, Petrović IM, Ristić-Fira A. Alteration of p53 and Bax/ Bcl-2 ratio by fotemustine and proton irradiation. in INFN-LNS Activity report 2009. 2010;:234-237.
https://hdl.handle.net/21.15107/rcub_vinar_10506 .

Korićanac, Lela, Žakula, Jelena, Keta, Otilija D., Privitera G., Cirrone, G. A. P., Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Alteration of p53 and Bax/ Bcl-2 ratio by fotemustine and proton irradiation" in INFN-LNS Activity report 2009 (2010):234-237,
https://hdl.handle.net/21.15107/rcub_vinar_10506 .

TY  - JOUR
AU  - Korićanac, Lela
AU  - Petrović, Ivan M.
AU  - Privitera, G.
AU  - Cuttone, Giacomo
AU  - Ristić-Fira, Aleksandra
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6724
AB  - Chemoresistance is a major problem in the treatment of malignant melanoma. The mainstay of treatment for melanoma is the DNA-alkylating agent dacarbazine (DTIC). Fotemustine (FM), a member of the chloroethylnitrosourea group of alkylating agents, has also demonstrated significant antitumor effects in malignant melanoma. However, the intrinsic and acquired resistance of melanoma limits the clinical application of these drugs. Melanomas are also extremely radioresistant. With the objective of enhancing growth inhibition of melanoma cells, combined treatments of FM or DTIC with proton irradiation have been investigated. These effects were studied on HTB140 melanoma cell viability and proliferation. Cells exposed to treatment with FM and protons have shown inhibition of cell growth and significant reduction of proliferation capacity compared to single irradiation or drug treatment. Treatment with DTIC and protons has shown improved growth inhibition compared to appropriate single drug treatment, while the effects of single proton irradiation have been the most pronounced.
T2  - Russian Journal of Physical Chemistry A
T1  - HTB140 melanoma cells under proton irradiation and/or alkylating agents
VL  - 81
IS  - 9
SP  - 1467
EP  - 1470
DO  - 10.1134/S0036024407090233
ER  - 

@article{
author = "Korićanac, Lela and Petrović, Ivan M. and Privitera, G. and Cuttone, Giacomo and Ristić-Fira, Aleksandra",
year = "2007",
abstract = "Chemoresistance is a major problem in the treatment of malignant melanoma. The mainstay of treatment for melanoma is the DNA-alkylating agent dacarbazine (DTIC). Fotemustine (FM), a member of the chloroethylnitrosourea group of alkylating agents, has also demonstrated significant antitumor effects in malignant melanoma. However, the intrinsic and acquired resistance of melanoma limits the clinical application of these drugs. Melanomas are also extremely radioresistant. With the objective of enhancing growth inhibition of melanoma cells, combined treatments of FM or DTIC with proton irradiation have been investigated. These effects were studied on HTB140 melanoma cell viability and proliferation. Cells exposed to treatment with FM and protons have shown inhibition of cell growth and significant reduction of proliferation capacity compared to single irradiation or drug treatment. Treatment with DTIC and protons has shown improved growth inhibition compared to appropriate single drug treatment, while the effects of single proton irradiation have been the most pronounced.",
journal = "Russian Journal of Physical Chemistry A",
title = "HTB140 melanoma cells under proton irradiation and/or alkylating agents",
volume = "81",
number = "9",
pages = "1467-1470",
doi = "10.1134/S0036024407090233"
}

Korićanac, L., Petrović, I. M., Privitera, G., Cuttone, G.,& Ristić-Fira, A.. (2007). HTB140 melanoma cells under proton irradiation and/or alkylating agents. in Russian Journal of Physical Chemistry A, 81(9), 1467-1470.
https://doi.org/10.1134/S0036024407090233

Korićanac L, Petrović IM, Privitera G, Cuttone G, Ristić-Fira A. HTB140 melanoma cells under proton irradiation and/or alkylating agents. in Russian Journal of Physical Chemistry A. 2007;81(9):1467-1470.
doi:10.1134/S0036024407090233 .

Korićanac, Lela, Petrović, Ivan M., Privitera, G., Cuttone, Giacomo, Ristić-Fira, Aleksandra, "HTB140 melanoma cells under proton irradiation and/or alkylating agents" in Russian Journal of Physical Chemistry A, 81, no. 9 (2007):1467-1470,
https://doi.org/10.1134/S0036024407090233 . .