TY  - JOUR
AU  - Marinković, Valentina D.
AU  - Agbaba, Danica
AU  - Karjikovic-Rajic, K
AU  - Vladimirov, Sote
AU  - Nedeljković, Jovan
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6377
AB  - The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Photochemical degradation of solid-state nisoldipine monitored by HPLC
VL  - 32
IS  - 4-5
SP  - 929
EP  - 935
DO  - 10.1016/S0731-7085(03)00194-8
ER  - 

@article{
author = "Marinković, Valentina D. and Agbaba, Danica and Karjikovic-Rajic, K and Vladimirov, Sote and Nedeljković, Jovan",
year = "2003",
abstract = "The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Photochemical degradation of solid-state nisoldipine monitored by HPLC",
volume = "32",
number = "4-5",
pages = "929-935",
doi = "10.1016/S0731-7085(03)00194-8"
}

Marinković, V. D., Agbaba, D., Karjikovic-Rajic, K., Vladimirov, S.,& Nedeljković, J.. (2003). Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 929-935.
https://doi.org/10.1016/S0731-7085(03)00194-8

Marinković VD, Agbaba D, Karjikovic-Rajic K, Vladimirov S, Nedeljković J. Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):929-935.
doi:10.1016/S0731-7085(03)00194-8 .

Marinković, Valentina D., Agbaba, Danica, Karjikovic-Rajic, K, Vladimirov, Sote, Nedeljković, Jovan, "Photochemical degradation of solid-state nisoldipine monitored by HPLC" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):929-935,
https://doi.org/10.1016/S0731-7085(03)00194-8 . .

TY  - JOUR
AU  - Marinković, Valentina D.
AU  - Milojković, Smiljana S.
AU  - Nedeljković, Jovan
AU  - Čomor, Jožef J.
AU  - Agbaba, Danica
AU  - Živanov-Stakić, Dobrila
PY  - 1997
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2099
AB  - A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations
VL  - 16
IS  - 3
SP  - 425
EP  - 429
DO  - 10.1016/S0731-7085(97)00079-4
ER  - 

@article{
author = "Marinković, Valentina D. and Milojković, Smiljana S. and Nedeljković, Jovan and Čomor, Jožef J. and Agbaba, Danica and Živanov-Stakić, Dobrila",
year = "1997",
abstract = "A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations",
volume = "16",
number = "3",
pages = "425-429",
doi = "10.1016/S0731-7085(97)00079-4"
}

Marinković, V. D., Milojković, S. S., Nedeljković, J., Čomor, J. J., Agbaba, D.,& Živanov-Stakić, D.. (1997). Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations. in Journal of Pharmaceutical and Biomedical Analysis, 16(3), 425-429.
https://doi.org/10.1016/S0731-7085(97)00079-4

Marinković VD, Milojković SS, Nedeljković J, Čomor JJ, Agbaba D, Živanov-Stakić D. Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations. in Journal of Pharmaceutical and Biomedical Analysis. 1997;16(3):425-429.
doi:10.1016/S0731-7085(97)00079-4 .

Marinković, Valentina D., Milojković, Smiljana S., Nedeljković, Jovan, Čomor, Jožef J., Agbaba, Danica, Živanov-Stakić, Dobrila, "Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations" in Journal of Pharmaceutical and Biomedical Analysis, 16, no. 3 (1997):425-429,
https://doi.org/10.1016/S0731-7085(97)00079-4 . .

TY  - JOUR
AU  - Marinković, Valentina D.
AU  - Gudžić, Branislav T.
AU  - Milojković, Smiljana S.
AU  - Nedeljković, Jovan
AU  - Čomor, Jožef J.
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2020
AB  - The stability of isosorbide 5-mononitrate (5-ISMN) was investigated at 40 degrees C under dry and wet air (75% relative humidity). The degradation products were identified and quantified by means of capillary GC-MS preceded by drying and silylation of the samples. The only degradation products identified were the two diastereoisomers of isosorbide. From the initial slope of degradation curves the maximal degradation rates were estimated to be 0.17 and 2.44% year(-1) under dry and wet conditions, respectively.
T2  - Journal of Chromatography A
T1  - Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability
VL  - 746
IS  - 2
SP  - 286
EP  - 288
DO  - 10.1016/0021-9673(96)00296-8
ER  - 

@article{
author = "Marinković, Valentina D. and Gudžić, Branislav T. and Milojković, Smiljana S. and Nedeljković, Jovan and Čomor, Jožef J.",
year = "1996",
abstract = "The stability of isosorbide 5-mononitrate (5-ISMN) was investigated at 40 degrees C under dry and wet air (75% relative humidity). The degradation products were identified and quantified by means of capillary GC-MS preceded by drying and silylation of the samples. The only degradation products identified were the two diastereoisomers of isosorbide. From the initial slope of degradation curves the maximal degradation rates were estimated to be 0.17 and 2.44% year(-1) under dry and wet conditions, respectively.",
journal = "Journal of Chromatography A",
title = "Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability",
volume = "746",
number = "2",
pages = "286-288",
doi = "10.1016/0021-9673(96)00296-8"
}

Marinković, V. D., Gudžić, B. T., Milojković, S. S., Nedeljković, J.,& Čomor, J. J.. (1996). Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability. in Journal of Chromatography A, 746(2), 286-288.
https://doi.org/10.1016/0021-9673(96)00296-8

Marinković VD, Gudžić BT, Milojković SS, Nedeljković J, Čomor JJ. Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability. in Journal of Chromatography A. 1996;746(2):286-288.
doi:10.1016/0021-9673(96)00296-8 .

Marinković, Valentina D., Gudžić, Branislav T., Milojković, Smiljana S., Nedeljković, Jovan, Čomor, Jožef J., "Gas chromatography mass spectrometry study of isosorbide 5-mononitrate stability" in Journal of Chromatography A, 746, no. 2 (1996):286-288,
https://doi.org/10.1016/0021-9673(96)00296-8 . .