TY  - JOUR
AU  - Marinković, Valentina D.
AU  - Milojković, Smiljana S.
AU  - Nedeljković, Jovan
AU  - Čomor, Jožef J.
AU  - Agbaba, Danica
AU  - Živanov-Stakić, Dobrila
PY  - 1997
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2099
AB  - A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations
VL  - 16
IS  - 3
SP  - 425
EP  - 429
DO  - 10.1016/S0731-7085(97)00079-4
ER  - 

@article{
author = "Marinković, Valentina D. and Milojković, Smiljana S. and Nedeljković, Jovan and Čomor, Jožef J. and Agbaba, Danica and Živanov-Stakić, Dobrila",
year = "1997",
abstract = "A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (ISSMN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 mu g in dosage formulations for ISSMN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of ISSMN. (C) 1997 Elsevier Science B.V.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations",
volume = "16",
number = "3",
pages = "425-429",
doi = "10.1016/S0731-7085(97)00079-4"
}

Marinković, V. D., Milojković, S. S., Nedeljković, J., Čomor, J. J., Agbaba, D.,& Živanov-Stakić, D.. (1997). Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations. in Journal of Pharmaceutical and Biomedical Analysis, 16(3), 425-429.
https://doi.org/10.1016/S0731-7085(97)00079-4

Marinković VD, Milojković SS, Nedeljković J, Čomor JJ, Agbaba D, Živanov-Stakić D. Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations. in Journal of Pharmaceutical and Biomedical Analysis. 1997;16(3):425-429.
doi:10.1016/S0731-7085(97)00079-4 .

Marinković, Valentina D., Milojković, Smiljana S., Nedeljković, Jovan, Čomor, Jožef J., Agbaba, Danica, Živanov-Stakić, Dobrila, "Gas chromatography mass spectrometry determination of isosorbide 5-mononitrate and related impurities in raw materials and dosage formulations" in Journal of Pharmaceutical and Biomedical Analysis, 16, no. 3 (1997):425-429,
https://doi.org/10.1016/S0731-7085(97)00079-4 . .