TY  - JOUR
AU  - Ghalib, Raza Murad
AU  - Hashim, Rokiah
AU  - Sulaiman, Othman
AU  - Jawad, Ali
AU  - Mehdi, Sayed Hasan
AU  - Bogdanović, Goran A.
AU  - Trifunović, Srećko R.
AU  - Kawamura, Fumio
AU  - Ahamed, B. M. Khadeer
AU  - Majid, Amin Malik Shah Abdul
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1431
AB  - Background: Heterocyclic molecules have been synthesized by a green and facile strategy. These mole-cules contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single crystal X-ray analysis. These compounds have anticancer activity. Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1: 1 were heated on water bath for 15 minutes. The reaction mixtures were dried on rotary evaporator and crystallized with chloro-form- n-hexane (1: 1 v/v) to give the colorless crystals of 1 And 2 respectively. Compounds 3 and 4 were synthe-sized by adding o-phenylenediamine to the completed reaction mixtures of 1 and 2 and each was further heated on water bath for 5 minutes. The dried reaction mixtures were chromatographed over a silica gel column and crystalized as 3 and 4. Results: This strategy resulted novel class of anticancer benzazocines (3 and 4). Conclusion: This method features mild reaction conditions and simple operation. The synthesis completes in two steps; from ninhydrin to 1 and 2 and from 1 and 2 to 3 and 4. The same basic skeleton of 3 and 4 and the same synthesis procedure clearly shows the general applicability of this reaction that is also proved enough by single crystal X-ray analysis and the strategy can be applicable for a wide range of other substrates. The obtained compounds are potential anticancer agents.
T2  - Current Organic Synthesis
T1  - Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity
VL  - 14
IS  - 1
SP  - 127
EP  - 136
DO  - 10.2174/1570179413666151218201848
ER  - 

@article{
author = "Ghalib, Raza Murad and Hashim, Rokiah and Sulaiman, Othman and Jawad, Ali and Mehdi, Sayed Hasan and Bogdanović, Goran A. and Trifunović, Srećko R. and Kawamura, Fumio and Ahamed, B. M. Khadeer and Majid, Amin Malik Shah Abdul",
year = "2017",
abstract = "Background: Heterocyclic molecules have been synthesized by a green and facile strategy. These mole-cules contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single crystal X-ray analysis. These compounds have anticancer activity. Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1: 1 were heated on water bath for 15 minutes. The reaction mixtures were dried on rotary evaporator and crystallized with chloro-form- n-hexane (1: 1 v/v) to give the colorless crystals of 1 And 2 respectively. Compounds 3 and 4 were synthe-sized by adding o-phenylenediamine to the completed reaction mixtures of 1 and 2 and each was further heated on water bath for 5 minutes. The dried reaction mixtures were chromatographed over a silica gel column and crystalized as 3 and 4. Results: This strategy resulted novel class of anticancer benzazocines (3 and 4). Conclusion: This method features mild reaction conditions and simple operation. The synthesis completes in two steps; from ninhydrin to 1 and 2 and from 1 and 2 to 3 and 4. The same basic skeleton of 3 and 4 and the same synthesis procedure clearly shows the general applicability of this reaction that is also proved enough by single crystal X-ray analysis and the strategy can be applicable for a wide range of other substrates. The obtained compounds are potential anticancer agents.",
journal = "Current Organic Synthesis",
title = "Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity",
volume = "14",
number = "1",
pages = "127-136",
doi = "10.2174/1570179413666151218201848"
}

Ghalib, R. M., Hashim, R., Sulaiman, O., Jawad, A., Mehdi, S. H., Bogdanović, G. A., Trifunović, S. R., Kawamura, F., Ahamed, B. M. K.,& Majid, A. M. S. A.. (2017). Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity. in Current Organic Synthesis, 14(1), 127-136.
https://doi.org/10.2174/1570179413666151218201848

Ghalib RM, Hashim R, Sulaiman O, Jawad A, Mehdi SH, Bogdanović GA, Trifunović SR, Kawamura F, Ahamed BMK, Majid AMSA. Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity. in Current Organic Synthesis. 2017;14(1):127-136.
doi:10.2174/1570179413666151218201848 .

Ghalib, Raza Murad, Hashim, Rokiah, Sulaiman, Othman, Jawad, Ali, Mehdi, Sayed Hasan, Bogdanović, Goran A., Trifunović, Srećko R., Kawamura, Fumio, Ahamed, B. M. Khadeer, Majid, Amin Malik Shah Abdul, "Green Synthesis of Novel Class of Benzazocine Derivatives, their Crystal Structures and Anticancer Activity" in Current Organic Synthesis, 14, no. 1 (2017):127-136,
https://doi.org/10.2174/1570179413666151218201848 . .