TY  - JOUR
AU  - Banjac, Katarina
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Essack, Magbubah
AU  - Gluvić, Zoran
AU  - Šunderić, Miloš
AU  - Nedić, Olgica
AU  - Isenović, Esma R.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13184
AB  - Background We previously demonstrated that insulin-like growth factor-1 (IGF-1) regulates sodium/potassium adenosine triphosphatase (Na+/K+-ATPase) in vascular smooth muscle cells (VSMC) via phosphatidylinositol-3 kinase (PI3K). Taking into account that others’ work show that IGF-1 activates the PI3K/protein kinase B (Akt) signaling pathway in many different cells, we here further questioned if the Akt/mammalian target of rapamycin (mTOR)/ribosomal protein p70 S6 kinase (S6K) pathway stimulates Na+/K+-ATPase, an essential protein for maintaining normal heart function. Methods and results There were 14 adult male Wistar rats, half of whom received bolus injections of IGF-1 (50 μg/kg) for 24 h. We evaluated cardiac Na+/K+-ATPase expression, activity, and serum IGF-1 levels. Additionally, we examined the phosphorylated forms of the following proteins: insulin receptor substrate (IRS), phosphoinositide-dependent kinase-1 (PDK-1), Akt, mTOR, S6K, and α subunit of Na+/K+-ATPase. Additionally, the mRNA expression of the Na+/K+-ATPase α1 subunit was evaluated. Treatment with IGF-1 increases levels of serum IGF-1 and stimulates Na+/K+-ATPase activity, phosphorylation of α subunit of Na+/K+-ATPase on Ser23, and protein expression of α2 subunit. Furthermore, IGF-1 treatment increased phosphorylation of IRS-1 on Tyr1222, Akt on Ser473, PDK-1 on Ser241, mTOR on Ser2481 and Ser2448, and S6K on Thr421/Ser424. The concentration of IGF-1 in serum positively correlates with Na+/K+-ATPase activity and the phosphorylated form of mTOR (Ser2448), while Na+/K+-ATPase activity positively correlates with the phosphorylated form of IRS-1 (Tyr1222) and mTOR (Ser2448). Conclusion These results indicate that the Akt/mTOR/S6K signalling pathway may be involved in the IGF-1 regulating cardiac Na+/K+-ATPase expression and activity
T2  - Molecular Biology Reports
T1  - The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na+/K+-ATPase
VL  - 51
IS  - 1
DO  - 10.1007/s11033-024-09451-3
ER  - 

@article{
author = "Banjac, Katarina and Obradović, Milan and Zafirović, Sonja and Essack, Magbubah and Gluvić, Zoran and Šunderić, Miloš and Nedić, Olgica and Isenović, Esma R.",
year = "2024",
abstract = "Background We previously demonstrated that insulin-like growth factor-1 (IGF-1) regulates sodium/potassium adenosine triphosphatase (Na+/K+-ATPase) in vascular smooth muscle cells (VSMC) via phosphatidylinositol-3 kinase (PI3K). Taking into account that others’ work show that IGF-1 activates the PI3K/protein kinase B (Akt) signaling pathway in many different cells, we here further questioned if the Akt/mammalian target of rapamycin (mTOR)/ribosomal protein p70 S6 kinase (S6K) pathway stimulates Na+/K+-ATPase, an essential protein for maintaining normal heart function. Methods and results There were 14 adult male Wistar rats, half of whom received bolus injections of IGF-1 (50 μg/kg) for 24 h. We evaluated cardiac Na+/K+-ATPase expression, activity, and serum IGF-1 levels. Additionally, we examined the phosphorylated forms of the following proteins: insulin receptor substrate (IRS), phosphoinositide-dependent kinase-1 (PDK-1), Akt, mTOR, S6K, and α subunit of Na+/K+-ATPase. Additionally, the mRNA expression of the Na+/K+-ATPase α1 subunit was evaluated. Treatment with IGF-1 increases levels of serum IGF-1 and stimulates Na+/K+-ATPase activity, phosphorylation of α subunit of Na+/K+-ATPase on Ser23, and protein expression of α2 subunit. Furthermore, IGF-1 treatment increased phosphorylation of IRS-1 on Tyr1222, Akt on Ser473, PDK-1 on Ser241, mTOR on Ser2481 and Ser2448, and S6K on Thr421/Ser424. The concentration of IGF-1 in serum positively correlates with Na+/K+-ATPase activity and the phosphorylated form of mTOR (Ser2448), while Na+/K+-ATPase activity positively correlates with the phosphorylated form of IRS-1 (Tyr1222) and mTOR (Ser2448). Conclusion These results indicate that the Akt/mTOR/S6K signalling pathway may be involved in the IGF-1 regulating cardiac Na+/K+-ATPase expression and activity",
journal = "Molecular Biology Reports",
title = "The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na+/K+-ATPase",
volume = "51",
number = "1",
doi = "10.1007/s11033-024-09451-3"
}

Banjac, K., Obradović, M., Zafirović, S., Essack, M., Gluvić, Z., Šunderić, M., Nedić, O.,& Isenović, E. R.. (2024). The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na+/K+-ATPase. in Molecular Biology Reports, 51(1).
https://doi.org/10.1007/s11033-024-09451-3

Banjac K, Obradović M, Zafirović S, Essack M, Gluvić Z, Šunderić M, Nedić O, Isenović ER. The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na+/K+-ATPase. in Molecular Biology Reports. 2024;51(1).
doi:10.1007/s11033-024-09451-3 .

Banjac, Katarina, Obradović, Milan, Zafirović, Sonja, Essack, Magbubah, Gluvić, Zoran, Šunderić, Miloš, Nedić, Olgica, Isenović, Esma R., "The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na+/K+-ATPase" in Molecular Biology Reports, 51, no. 1 (2024),
https://doi.org/10.1007/s11033-024-09451-3 . .

TY  - JOUR
AU  - Tomasović, M.
AU  - Sinik, M.
AU  - Gluvić, Zoran
AU  - Zafirović, Sonja
AU  - Isenović, Esma
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12878
AB  - Context. Propylthiouracil (PTU) could cause lupus or vasculitis-like hypersensitivities thus interfering with some other concomitant diseases. Objective. Clinicians must be aware of the side effects of medications, particularly after their introduction and long-term use. Some clinical manifestations may be similar to well-known drug side effects or hypersensitivity. Every unusual clinical scenario related to drug use must be evaluated individually and thoroughly. Subjects and Methods. Hands and feet skin changes were observed several days after PTU administration in a male patient with severe diffuse toxic goitre. A complete blood count, biochemistry analyses, thyroid function tests and antibodies, and immunology analyses were performed. Results. As the skin changes were distributed regionally, liver function tests were normal, and there were no signs of clinical deterioration, it was decided to continue PTU treatment and monitor the patient. The initial maculopapular rash quickly turned vesicular, then scaly. After two weeks, the skin changes were wholly restored, with no scarring. Hand, Foot, and Mouth disease (HFMD) was diagnosed after a thorough epidemiological survey and clinical workout. Conclusions. Our case study demonstrates that skin changes associated with HFMD may resemble those associated with PTU-induced vasculitis.
T2  - Acta Endocrinologica (Bucharest)
T1  - Case Report of Hand and Foot Skin Changes Resembling PTU-Induced Vasculitis in a Young Male with Diffuse Toxic Goitre
VL  - 19
IS  - 3
SP  - 380
EP  - 385
DO  - 10.4183/aeb.2023.380
ER  - 

@article{
author = "Tomasović, M. and Sinik, M. and Gluvić, Zoran and Zafirović, Sonja and Isenović, Esma",
year = "2023",
abstract = "Context. Propylthiouracil (PTU) could cause lupus or vasculitis-like hypersensitivities thus interfering with some other concomitant diseases. Objective. Clinicians must be aware of the side effects of medications, particularly after their introduction and long-term use. Some clinical manifestations may be similar to well-known drug side effects or hypersensitivity. Every unusual clinical scenario related to drug use must be evaluated individually and thoroughly. Subjects and Methods. Hands and feet skin changes were observed several days after PTU administration in a male patient with severe diffuse toxic goitre. A complete blood count, biochemistry analyses, thyroid function tests and antibodies, and immunology analyses were performed. Results. As the skin changes were distributed regionally, liver function tests were normal, and there were no signs of clinical deterioration, it was decided to continue PTU treatment and monitor the patient. The initial maculopapular rash quickly turned vesicular, then scaly. After two weeks, the skin changes were wholly restored, with no scarring. Hand, Foot, and Mouth disease (HFMD) was diagnosed after a thorough epidemiological survey and clinical workout. Conclusions. Our case study demonstrates that skin changes associated with HFMD may resemble those associated with PTU-induced vasculitis.",
journal = "Acta Endocrinologica (Bucharest)",
title = "Case Report of Hand and Foot Skin Changes Resembling PTU-Induced Vasculitis in a Young Male with Diffuse Toxic Goitre",
volume = "19",
number = "3",
pages = "380-385",
doi = "10.4183/aeb.2023.380"
}

Tomasović, M., Sinik, M., Gluvić, Z., Zafirović, S.,& Isenović, E.. (2023). Case Report of Hand and Foot Skin Changes Resembling PTU-Induced Vasculitis in a Young Male with Diffuse Toxic Goitre. in Acta Endocrinologica (Bucharest), 19(3), 380-385.
https://doi.org/10.4183/aeb.2023.380

Tomasović M, Sinik M, Gluvić Z, Zafirović S, Isenović E. Case Report of Hand and Foot Skin Changes Resembling PTU-Induced Vasculitis in a Young Male with Diffuse Toxic Goitre. in Acta Endocrinologica (Bucharest). 2023;19(3):380-385.
doi:10.4183/aeb.2023.380 .

Tomasović, M., Sinik, M., Gluvić, Zoran, Zafirović, Sonja, Isenović, Esma, "Case Report of Hand and Foot Skin Changes Resembling PTU-Induced Vasculitis in a Young Male with Diffuse Toxic Goitre" in Acta Endocrinologica (Bucharest), 19, no. 3 (2023):380-385,
https://doi.org/10.4183/aeb.2023.380 . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Tomašević, Ratko
AU  - Bojović, Ksenija
AU  - Obradović, Milan
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12026
AB  - Non-alcoholic fatty liver disease (NAFLD) is among the most frequently encountered chronic liver diseases in everyday clinical practice. It is considered the hepatic manifestation of metabolic syndrome. Today, liver biopsy is still the gold standard for NAFLD confirmation and assessing NAFLD's possible progression to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Because of the high prevalence of NAFLD and potential associated risks of invasive diagnostic procedures, it is of great interest to recruit the patients for liver biopsy. However, as the presence of liver fibrosis determines the further clinical course, liver biopsy is expectedly reserved for those with increased fibrosis risk. The quality of liver biopsy recruitment and patient monitoring could be significantly improved by using non-invasive tools to assess liver fibrosis presence and interactive collaboration between general practitioners, gastroenterologists, and endocrinologists. As a result, the quality of liver biopsy recruitment and patients monitoring could be significantly improved. Here, we proposed clinical practice guidelines that could be implemented for everyday clinical practice in NAFLD patients.
T2  - Emergency and Critical Care Medicine
T1  - Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines
VL  - 2
IS  - 1
SP  - 12
EP  - 22
DO  - 10.1097/EC9.0000000000000016
ER  - 

@article{
author = "Gluvić, Zoran and Tomašević, Ratko and Bojović, Ksenija and Obradović, Milan and Isenović, Esma R.",
year = "2022",
abstract = "Non-alcoholic fatty liver disease (NAFLD) is among the most frequently encountered chronic liver diseases in everyday clinical practice. It is considered the hepatic manifestation of metabolic syndrome. Today, liver biopsy is still the gold standard for NAFLD confirmation and assessing NAFLD's possible progression to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Because of the high prevalence of NAFLD and potential associated risks of invasive diagnostic procedures, it is of great interest to recruit the patients for liver biopsy. However, as the presence of liver fibrosis determines the further clinical course, liver biopsy is expectedly reserved for those with increased fibrosis risk. The quality of liver biopsy recruitment and patient monitoring could be significantly improved by using non-invasive tools to assess liver fibrosis presence and interactive collaboration between general practitioners, gastroenterologists, and endocrinologists. As a result, the quality of liver biopsy recruitment and patients monitoring could be significantly improved. Here, we proposed clinical practice guidelines that could be implemented for everyday clinical practice in NAFLD patients.",
journal = "Emergency and Critical Care Medicine",
title = "Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines",
volume = "2",
number = "1",
pages = "12-22",
doi = "10.1097/EC9.0000000000000016"
}

Gluvić, Z., Tomašević, R., Bojović, K., Obradović, M.,& Isenović, E. R.. (2022). Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines. in Emergency and Critical Care Medicine, 2(1), 12-22.
https://doi.org/10.1097/EC9.0000000000000016

Gluvić Z, Tomašević R, Bojović K, Obradović M, Isenović ER. Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines. in Emergency and Critical Care Medicine. 2022;2(1):12-22.
doi:10.1097/EC9.0000000000000016 .

Gluvić, Zoran, Tomašević, Ratko, Bojović, Ksenija, Obradović, Milan, Isenović, Esma R., "Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines" in Emergency and Critical Care Medicine, 2, no. 1 (2022):12-22,
https://doi.org/10.1097/EC9.0000000000000016 . .

TY  - CONF
AU  - Tomasović, Martina
AU  - Sinik, Marija
AU  - Joksimović, Bojan
AU  - Lacković, Milena
AU  - Samardžić, Vladimir
AU  - Vujović, Marina
AU  - Gluvić, Zoran
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12029
AB  - Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became vesicular shortly after and then scaly. After two weeks, skin changes were entirely restored with no scaring. Taking into account thorough epidemiological survey, clinical course, and performed diagnostics, presented skin changes were diagnosed as Hand, Foot, and Mouth disease (HFMD). Clinicians must be aware of the side effects of used drugs, especially after their introduction. Some clinical presentations could only resemble expected or well-known side-effects, intolerance, or hypersensitivity to the used drug. Every clinical presentation associated with any drug introduction must be thoroughly evaluated. The presented case revealed that skin changes of HFMD mimicked PTU-induced vasculitis.
C3  - Endocrine Abstracts
T1  - Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report
DO  - 10.1530/endoabs.81.EP1030
ER  - 

@conference{
author = "Tomasović, Martina and Sinik, Marija and Joksimović, Bojan and Lacković, Milena and Samardžić, Vladimir and Vujović, Marina and Gluvić, Zoran and Obradović, Milan and Zafirović, Sonja and Isenović, Esma R.",
year = "2022",
abstract = "Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became vesicular shortly after and then scaly. After two weeks, skin changes were entirely restored with no scaring. Taking into account thorough epidemiological survey, clinical course, and performed diagnostics, presented skin changes were diagnosed as Hand, Foot, and Mouth disease (HFMD). Clinicians must be aware of the side effects of used drugs, especially after their introduction. Some clinical presentations could only resemble expected or well-known side-effects, intolerance, or hypersensitivity to the used drug. Every clinical presentation associated with any drug introduction must be thoroughly evaluated. The presented case revealed that skin changes of HFMD mimicked PTU-induced vasculitis.",
journal = "Endocrine Abstracts",
title = "Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report",
doi = "10.1530/endoabs.81.EP1030"
}

Tomasović, M., Sinik, M., Joksimović, B., Lacković, M., Samardžić, V., Vujović, M., Gluvić, Z., Obradović, M., Zafirović, S.,& Isenović, E. R.. (2022). Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report. in Endocrine Abstracts.
https://doi.org/10.1530/endoabs.81.EP1030

Tomasović M, Sinik M, Joksimović B, Lacković M, Samardžić V, Vujović M, Gluvić Z, Obradović M, Zafirović S, Isenović ER. Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report. in Endocrine Abstracts. 2022;.
doi:10.1530/endoabs.81.EP1030 .

Tomasović, Martina, Sinik, Marija, Joksimović, Bojan, Lacković, Milena, Samardžić, Vladimir, Vujović, Marina, Gluvić, Zoran, Obradović, Milan, Zafirović, Sonja, Isenović, Esma R., "Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report" in Endocrine Abstracts (2022),
https://doi.org/10.1530/endoabs.81.EP1030 . .

TY  - CONF
AU  - Tomasović, M.
AU  - Šinik, M.
AU  - Joksimović, Bojan
AU  - Lačković, M.
AU  - Samardžić, Vladimir
AU  - Gluvić, Zoran
AU  - Vujović, M.
AU  - Zafirović, Sonja
AU  - Mačvanin, Mirjana
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12034
AB  - Uvod i cilj. Hipotiroza je često endokrinološko oboljenje, sa širokim spektrom kliničke prezentacije: od asimptomatske do multiorganske, koja prognostički može biti ozbiljna. Atipične prezentacije hipotiroze retko mogu biti i inicijalne, poput perikardnog izliva (PI). Prikazujemo bolesnika sa novodijagnostikovanom primarnom hipotirozom, prezentovanom simptomima i znacima srčane insuficijencije, sa ehokardiografski detektovanim PI. Metode. Bolesnik je obrađen klinički, elektrokardiografski, laboratorijski i ultrasonografski (štitasta žlezda i srce). Rezultati. Muškarac star 47 godina se javlja u hitnu internističku ambulantu zbog otoka nogu, lica i zamaranja, trajanja oko godinu dana. Anamnestički bez poznatih komorbiditeta. Objektivno se kod hipometaboličnog bolesnika sa JVP 1+, bez prisustva Bekove trijade, detektuju pretibijalni edemi, bez drugog patološkog nalaza po sistemima. TA 110/70 mmHg, P 56/min. EKG: sinusni ritam, frekvence oko 55/min, niže voltaže, bez ST i T promena. U laboratorijskim analizama beleže se blaga normocitna anemija, HLP 2b i povišene vrednosti CK i transaminaza. TFT ukazuju na autoimunsku primarnu hipotirozu (TSH 35, FT4 <1.93, Anti TPO 234). Ehokardiografski nalaz ukazuje na cirkularni PI, bez znakova preteće tamponade, dok ultrazvuk štitaste žlezde odgovara hroničnom tiroiditisu. Vrednosti tumorskih i sistemskih autoimunskih markera su bez odstupanja. Započinje se postepenom supstitucijom levotiroksinom. Kontrolna ehokardiografska studija (pet nedelja nakon inicijalne) ukazuje na smanjenje PI, dok se laboratorijski registruje pad nivoa TSH (6.35). Zaključak. PI je retka inicijalna prezentacija hipotiroze, koja ako se prepozna blagovremeno, sprečava razvoj ozbiljnog kardiovaskularnog morbiditeta. Potrebno je, posebno kod mlađih bolesnika, razmotriti postojanje pridruženih uzroka PI (SBVT, maligne i infektivne bolesti), koji se klinički mogu prezentovati mitigirano.
C3  - KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka
T1  - Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja
SP  - 134
EP  - 134
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12034
ER  - 

@conference{
author = "Tomasović, M. and Šinik, M. and Joksimović, Bojan and Lačković, M. and Samardžić, Vladimir and Gluvić, Zoran and Vujović, M. and Zafirović, Sonja and Mačvanin, Mirjana and Isenović, Esma R.",
year = "2022",
abstract = "Uvod i cilj. Hipotiroza je često endokrinološko oboljenje, sa širokim spektrom kliničke prezentacije: od asimptomatske do multiorganske, koja prognostički može biti ozbiljna. Atipične prezentacije hipotiroze retko mogu biti i inicijalne, poput perikardnog izliva (PI). Prikazujemo bolesnika sa novodijagnostikovanom primarnom hipotirozom, prezentovanom simptomima i znacima srčane insuficijencije, sa ehokardiografski detektovanim PI. Metode. Bolesnik je obrađen klinički, elektrokardiografski, laboratorijski i ultrasonografski (štitasta žlezda i srce). Rezultati. Muškarac star 47 godina se javlja u hitnu internističku ambulantu zbog otoka nogu, lica i zamaranja, trajanja oko godinu dana. Anamnestički bez poznatih komorbiditeta. Objektivno se kod hipometaboličnog bolesnika sa JVP 1+, bez prisustva Bekove trijade, detektuju pretibijalni edemi, bez drugog patološkog nalaza po sistemima. TA 110/70 mmHg, P 56/min. EKG: sinusni ritam, frekvence oko 55/min, niže voltaže, bez ST i T promena. U laboratorijskim analizama beleže se blaga normocitna anemija, HLP 2b i povišene vrednosti CK i transaminaza. TFT ukazuju na autoimunsku primarnu hipotirozu (TSH 35, FT4 <1.93, Anti TPO 234). Ehokardiografski nalaz ukazuje na cirkularni PI, bez znakova preteće tamponade, dok ultrazvuk štitaste žlezde odgovara hroničnom tiroiditisu. Vrednosti tumorskih i sistemskih autoimunskih markera su bez odstupanja. Započinje se postepenom supstitucijom levotiroksinom. Kontrolna ehokardiografska studija (pet nedelja nakon inicijalne) ukazuje na smanjenje PI, dok se laboratorijski registruje pad nivoa TSH (6.35). Zaključak. PI je retka inicijalna prezentacija hipotiroze, koja ako se prepozna blagovremeno, sprečava razvoj ozbiljnog kardiovaskularnog morbiditeta. Potrebno je, posebno kod mlađih bolesnika, razmotriti postojanje pridruženih uzroka PI (SBVT, maligne i infektivne bolesti), koji se klinički mogu prezentovati mitigirano.",
journal = "KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka",
title = "Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja",
pages = "134-134",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12034"
}

Tomasović, M., Šinik, M., Joksimović, B., Lačković, M., Samardžić, V., Gluvić, Z., Vujović, M., Zafirović, S., Mačvanin, M.,& Isenović, E. R.. (2022). Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja. in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka, 134-134.
https://hdl.handle.net/21.15107/rcub_vinar_12034

Tomasović M, Šinik M, Joksimović B, Lačković M, Samardžić V, Gluvić Z, Vujović M, Zafirović S, Mačvanin M, Isenović ER. Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja. in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka. 2022;:134-134.
https://hdl.handle.net/21.15107/rcub_vinar_12034 .

Tomasović, M., Šinik, M., Joksimović, Bojan, Lačković, M., Samardžić, Vladimir, Gluvić, Zoran, Vujović, M., Zafirović, Sonja, Mačvanin, Mirjana, Isenović, Esma R., "Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja" in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka (2022):134-134,
https://hdl.handle.net/21.15107/rcub_vinar_12034 .

TY  - CONF
AU  - Gluvić, Zoran
AU  - Lačković, Milena
AU  - Samardžić, Vladimir
AU  - Tomašević, Ratko
AU  - Pavlović, Aleksandar
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Mladenović, Violeta
AU  - Radenković, Saša
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12035
C3  - 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata
T1  - Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12035
ER  - 

@conference{
author = "Gluvić, Zoran and Lačković, Milena and Samardžić, Vladimir and Tomašević, Ratko and Pavlović, Aleksandar and Obradović, Milan and Zafirović, Sonja and Mladenović, Violeta and Radenković, Saša and Isenović, Esma R.",
year = "2022",
journal = "4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata",
title = "Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12035"
}

Gluvić, Z., Lačković, M., Samardžić, V., Tomašević, R., Pavlović, A., Obradović, M., Zafirović, S., Mladenović, V., Radenković, S.,& Isenović, E. R.. (2022). Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse. in 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata.
https://hdl.handle.net/21.15107/rcub_vinar_12035

Gluvić Z, Lačković M, Samardžić V, Tomašević R, Pavlović A, Obradović M, Zafirović S, Mladenović V, Radenković S, Isenović ER. Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse. in 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata. 2022;.
https://hdl.handle.net/21.15107/rcub_vinar_12035 .

Gluvić, Zoran, Lačković, Milena, Samardžić, Vladimir, Tomašević, Ratko, Pavlović, Aleksandar, Obradović, Milan, Zafirović, Sonja, Mladenović, Violeta, Radenković, Saša, Isenović, Esma R., "Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse" in 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata (2022),
https://hdl.handle.net/21.15107/rcub_vinar_12035 .

TY  - CONF
AU  - Mitrović, Bojan
AU  - Samardžić, Vladimir
AU  - Gluvić, Zoran
AU  - Tomasević, Ratko
AU  - Obradović, Milan
AU  - Sudar-Milovanović, Emina
AU  - Isenović, Esma R.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12030
AB  - Introduction  Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.  Material and methods  A case-control study involved 30 non-obese subjects (BMI 18.5–30 kg/m2), who suffered from T2DM for less than 5 years. Such subjects are regularly under treatment by metformin (M) and sulphonylurea (SU) derivates. Liver steatosis severity is determined by ultrasonography and presented as grades 1, 2, and 3 (initial, moderate, and advanced liver steatosis), respectively, according to Singh et al. criteria (Singh et al. Indian J Endocr Metab 2013;17: 990–5).  Results  In the observed population, 14 (47%), 11 (36%), and 5 (17%) subjects are determined to grade 1, 2, and 3 liver steatosis severity groups, respectively. The mean values of iron homeostasis markers have not differed from normal values. Liver steatosis severity grades positively correlated with serum ferritin levels, and this correlation is not revealed in the cases with serum iron and transferrin levels.  Conclusion  The low grade of liver steatosis has predominated in non-obese T2DM subjects under treatment with M and SU, irrespective of glycemic control quality. An increase in liver steatosis severity follows the ascending trend of ferritin levels. Further studies are needed to elucidate the impact of the quality of T2DM control on liver steatosis severity and iron metabolism markers.
C3  - Endocrine Abstracts
T1  - Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD
DO  - 10.1530/endoabs.73.AEP294
ER  - 

@conference{
author = "Mitrović, Bojan and Samardžić, Vladimir and Gluvić, Zoran and Tomasević, Ratko and Obradović, Milan and Sudar-Milovanović, Emina and Isenović, Esma R.",
year = "2021",
abstract = "Introduction  Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.  Material and methods  A case-control study involved 30 non-obese subjects (BMI 18.5–30 kg/m2), who suffered from T2DM for less than 5 years. Such subjects are regularly under treatment by metformin (M) and sulphonylurea (SU) derivates. Liver steatosis severity is determined by ultrasonography and presented as grades 1, 2, and 3 (initial, moderate, and advanced liver steatosis), respectively, according to Singh et al. criteria (Singh et al. Indian J Endocr Metab 2013;17: 990–5).  Results  In the observed population, 14 (47%), 11 (36%), and 5 (17%) subjects are determined to grade 1, 2, and 3 liver steatosis severity groups, respectively. The mean values of iron homeostasis markers have not differed from normal values. Liver steatosis severity grades positively correlated with serum ferritin levels, and this correlation is not revealed in the cases with serum iron and transferrin levels.  Conclusion  The low grade of liver steatosis has predominated in non-obese T2DM subjects under treatment with M and SU, irrespective of glycemic control quality. An increase in liver steatosis severity follows the ascending trend of ferritin levels. Further studies are needed to elucidate the impact of the quality of T2DM control on liver steatosis severity and iron metabolism markers.",
journal = "Endocrine Abstracts",
title = "Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD",
doi = "10.1530/endoabs.73.AEP294"
}

Mitrović, B., Samardžić, V., Gluvić, Z., Tomasević, R., Obradović, M., Sudar-Milovanović, E.,& Isenović, E. R.. (2021). Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD. in Endocrine Abstracts.
https://doi.org/10.1530/endoabs.73.AEP294

Mitrović B, Samardžić V, Gluvić Z, Tomasević R, Obradović M, Sudar-Milovanović E, Isenović ER. Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD. in Endocrine Abstracts. 2021;.
doi:10.1530/endoabs.73.AEP294 .

Mitrović, Bojan, Samardžić, Vladimir, Gluvić, Zoran, Tomasević, Ratko, Obradović, Milan, Sudar-Milovanović, Emina, Isenović, Esma R., "Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD" in Endocrine Abstracts (2021),
https://doi.org/10.1530/endoabs.73.AEP294 . .

TY  - CHAP
AU  - Obradović, Milan
AU  - Radovanović, Jelena
AU  - Banjac, Katarina
AU  - Gluvić, Zoran
AU  - Zarić, Božidarka
AU  - Isenović, Esma R.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12031
AB  - This ten-chapter volume presents some recent advancements in health and disease. Chapter One explains the increased mortality rate owing to atherothrombosis and cardiovascular diseases. Chapter Two reviews the evidence for all current management strategies for recurrent hypoglycaemia in diabetes. Chapter Three provides information on the relationship between obesity and circulating levels of C-reactive protein. Chapter Four describes high-sensitivity C-reactive protein as a biomarker of diabetes and hypertension. Chapter Five studies the combination of two self-associating biopolymers such as high-molar-mass hyaluronan and chitosan for treatment of skin wounds. Chapter Six outlines an integrated approach to address the issues of high levels of stress and burnout in the workplace. Chapter Seven examines pericoronary adipose tissue as a possible storage and supply site for lipoproteins and apolipoproteins in the human coronary artery. Chapter Eight deals with corneal collagen cross-linking protocols for the management of keratoconus. Chapter Nine discusses free radicals, their formation and catabolism, and their beneficial and adverse effects on cellular activities. Finally, Chapter Ten details various diagnostic tests for vasculitis
PB  - Nova Science Publishers
T2  - Advances in Health and Disease
T1  - The Link between CRP and Obesity: Evidence from Human and Animal Studies
VL  - 50
SP  - 51
EP  - 73
DO  - 10.52305/INDG5982
ER  - 

@inbook{
author = "Obradović, Milan and Radovanović, Jelena and Banjac, Katarina and Gluvić, Zoran and Zarić, Božidarka and Isenović, Esma R.",
year = "2020",
abstract = "This ten-chapter volume presents some recent advancements in health and disease. Chapter One explains the increased mortality rate owing to atherothrombosis and cardiovascular diseases. Chapter Two reviews the evidence for all current management strategies for recurrent hypoglycaemia in diabetes. Chapter Three provides information on the relationship between obesity and circulating levels of C-reactive protein. Chapter Four describes high-sensitivity C-reactive protein as a biomarker of diabetes and hypertension. Chapter Five studies the combination of two self-associating biopolymers such as high-molar-mass hyaluronan and chitosan for treatment of skin wounds. Chapter Six outlines an integrated approach to address the issues of high levels of stress and burnout in the workplace. Chapter Seven examines pericoronary adipose tissue as a possible storage and supply site for lipoproteins and apolipoproteins in the human coronary artery. Chapter Eight deals with corneal collagen cross-linking protocols for the management of keratoconus. Chapter Nine discusses free radicals, their formation and catabolism, and their beneficial and adverse effects on cellular activities. Finally, Chapter Ten details various diagnostic tests for vasculitis",
publisher = "Nova Science Publishers",
journal = "Advances in Health and Disease",
booktitle = "The Link between CRP and Obesity: Evidence from Human and Animal Studies",
volume = "50",
pages = "51-73",
doi = "10.52305/INDG5982"
}

Obradović, M., Radovanović, J., Banjac, K., Gluvić, Z., Zarić, B.,& Isenović, E. R.. (2020). The Link between CRP and Obesity: Evidence from Human and Animal Studies. in Advances in Health and Disease
Nova Science Publishers., 50, 51-73.
https://doi.org/10.52305/INDG5982

Obradović M, Radovanović J, Banjac K, Gluvić Z, Zarić B, Isenović ER. The Link between CRP and Obesity: Evidence from Human and Animal Studies. in Advances in Health and Disease. 2020;50:51-73.
doi:10.52305/INDG5982 .

Obradović, Milan, Radovanović, Jelena, Banjac, Katarina, Gluvić, Zoran, Zarić, Božidarka, Isenović, Esma R., "The Link between CRP and Obesity: Evidence from Human and Animal Studies" in Advances in Health and Disease, 50 (2020):51-73,
https://doi.org/10.52305/INDG5982 . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Samardžić, Vladimir
AU  - Zarić, Božidarka
AU  - Đurković, Veslinka
AU  - Mladenović, Violeta
AU  - Stojanović, Marko
AU  - Isenović, Esma R.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12032
AB  - Congenital adrenal hyperplasia (CAH) is a rare genetic disorder which is caused by autosomal recessive mutations in genes, encoding enzymes involved in the process of glyco- and/ or the mineralocorticoid synthesis. It is most common 21-hydroxylase deficiency. Renal disease in patients with CAH is not common but is usually associated with hypertension. Here we present the case of hypotensive terminal chronic renal diseases, which required the support of hemodialysis in patients with noncompliance CAH intermediation with a loss of salt. Also, we analyzed the influence of hemodialysis treatment on biochemical indicators of quality of CAH treatment.
AB  - Kongenitalna adrenalna hiperplazija (KAH) je redak genetski poremećaj, koji je uzrokovan autozomno recesivnom mutacijom gena, koji enkodiraju enzime uključene u procesu glikoi/ili mineralokortikoidne sinteze. Najčešće se javlja deficit 21-hidroksilaze. Bubrežna bolest kod obolelih od KAH nije česta, a obično se povezuje sa hipertenzijom. Prikazuje se slučaj hipotenzivne terminalne hronične bubrežne bolesti, koja je zahtevala hemodijaliznu potporu kod nekomplijantnog bolesnika sa KAH sa gubitkom soli. Takođe, prikazan je uticaj hemodijaliznog tretmana na biohemijske pokazatelje kvaliteta tretmana KAH.
T2  - Medical investigation
T1  - Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia
T1  - Terminalna hronična bolest bubrega sa arterijskom hipotenzijom kod obolelog od klasične kongenitalne adrenalne hiperplazije
VL  - 51
IS  - 3
SP  - 29
EP  - 33
DO  - 10.5937/MedIst1703029G
ER  - 

@article{
author = "Gluvić, Zoran and Samardžić, Vladimir and Zarić, Božidarka and Đurković, Veslinka and Mladenović, Violeta and Stojanović, Marko and Isenović, Esma R.",
year = "2017",
abstract = "Congenital adrenal hyperplasia (CAH) is a rare genetic disorder which is caused by autosomal recessive mutations in genes, encoding enzymes involved in the process of glyco- and/ or the mineralocorticoid synthesis. It is most common 21-hydroxylase deficiency. Renal disease in patients with CAH is not common but is usually associated with hypertension. Here we present the case of hypotensive terminal chronic renal diseases, which required the support of hemodialysis in patients with noncompliance CAH intermediation with a loss of salt. Also, we analyzed the influence of hemodialysis treatment on biochemical indicators of quality of CAH treatment., Kongenitalna adrenalna hiperplazija (KAH) je redak genetski poremećaj, koji je uzrokovan autozomno recesivnom mutacijom gena, koji enkodiraju enzime uključene u procesu glikoi/ili mineralokortikoidne sinteze. Najčešće se javlja deficit 21-hidroksilaze. Bubrežna bolest kod obolelih od KAH nije česta, a obično se povezuje sa hipertenzijom. Prikazuje se slučaj hipotenzivne terminalne hronične bubrežne bolesti, koja je zahtevala hemodijaliznu potporu kod nekomplijantnog bolesnika sa KAH sa gubitkom soli. Takođe, prikazan je uticaj hemodijaliznog tretmana na biohemijske pokazatelje kvaliteta tretmana KAH.",
journal = "Medical investigation",
title = "Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia, Terminalna hronična bolest bubrega sa arterijskom hipotenzijom kod obolelog od klasične kongenitalne adrenalne hiperplazije",
volume = "51",
number = "3",
pages = "29-33",
doi = "10.5937/MedIst1703029G"
}

Gluvić, Z., Samardžić, V., Zarić, B., Đurković, V., Mladenović, V., Stojanović, M.,& Isenović, E. R.. (2017). Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia. in Medical investigation, 51(3), 29-33.
https://doi.org/10.5937/MedIst1703029G

Gluvić Z, Samardžić V, Zarić B, Đurković V, Mladenović V, Stojanović M, Isenović ER. Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia. in Medical investigation. 2017;51(3):29-33.
doi:10.5937/MedIst1703029G .

Gluvić, Zoran, Samardžić, Vladimir, Zarić, Božidarka, Đurković, Veslinka, Mladenović, Violeta, Stojanović, Marko, Isenović, Esma R., "Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia" in Medical investigation, 51, no. 3 (2017):29-33,
https://doi.org/10.5937/MedIst1703029G . .