TY  - JOUR
AU  - Brborić, Jasmina
AU  - Jovanović, Moma S.
AU  - Popovic, G
AU  - Kapetanovic, V
AU  - Vladimirov, Sote
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2981
AB  - The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).
T2  - Journal of the Serbian Chemical Society
T1  - Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
VL  - 71
IS  - 1
SP  - 55
EP  - 65
DO  - 10.2298/JSC0601055B
ER  - 

@article{
author = "Brborić, Jasmina and Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Vladimirov, Sote",
year = "2006",
abstract = "The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK(2) = 2.52 +/- 0.02; pK(3) = 5.86 +/- 0.06 and pK(4) = 10.9 +/- 0.1. The determinations were performed at 25 degrees C and an ionic strength of 0.1 mol/dm(3) (NaCl). The acidity constants (pK(1) = 1.3 +/- 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 degrees C and an ionic strength 1 mol/dm(3) (HCl, NaCl). DIIODIDA was labeled with teclinctiurn-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity ( GT 98%).",
journal = "Journal of the Serbian Chemical Society",
title = "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m",
volume = "71",
number = "1",
pages = "55-65",
doi = "10.2298/JSC0601055B"
}

Brborić, J., Jovanović, M. S., Popovic, G., Kapetanovic, V.,& Vladimirov, S.. (2006). Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society, 71(1), 55-65.
https://doi.org/10.2298/JSC0601055B

Brborić J, Jovanović MS, Popovic G, Kapetanovic V, Vladimirov S. Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society. 2006;71(1):55-65.
doi:10.2298/JSC0601055B .

Brborić, Jasmina, Jovanović, Moma S., Popovic, G, Kapetanovic, V, Vladimirov, Sote, "Acid-base equilibria of 2,4-diiodo-6-methylphenylearbamoylmethyl iminodiacetic acid and its labeling with technetium-99m" in Journal of the Serbian Chemical Society, 71, no. 1 (2006):55-65,
https://doi.org/10.2298/JSC0601055B . .

TY  - JOUR
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Jovanović, Moma S.
AU  - Dogović, N
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2794
AB  - The synthesis and characterization of N-[2-[[4-iodo-2,6-bis(1-methylethyl)phenyl]amino]-2-oxoethyl]-N-(carboxymethyl)glycine and N-[2-[(4-iodo-2,6-diethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine is presented, as well as a modified and improved synthesis of N-[2-[(2,4-diiodo-6-methylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine. These compounds are new agents for hepatobiliary imaging.
T2  - Monatshefte Fur Chemie
T1  - The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents
VL  - 135
IS  - 8
SP  - 1009
EP  - 1014
DO  - 10.1007/s00706-004-0174-x
ER  - 

@article{
author = "Brborić, Jasmina and Vladimirov, Sote and Jovanović, Moma S. and Dogović, N",
year = "2004",
abstract = "The synthesis and characterization of N-[2-[[4-iodo-2,6-bis(1-methylethyl)phenyl]amino]-2-oxoethyl]-N-(carboxymethyl)glycine and N-[2-[(4-iodo-2,6-diethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine is presented, as well as a modified and improved synthesis of N-[2-[(2,4-diiodo-6-methylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine. These compounds are new agents for hepatobiliary imaging.",
journal = "Monatshefte Fur Chemie",
title = "The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents",
volume = "135",
number = "8",
pages = "1009-1014",
doi = "10.1007/s00706-004-0174-x"
}

Brborić, J., Vladimirov, S., Jovanović, M. S.,& Dogović, N.. (2004). The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents. in Monatshefte Fur Chemie, 135(8), 1009-1014.
https://doi.org/10.1007/s00706-004-0174-x

Brborić J, Vladimirov S, Jovanović MS, Dogović N. The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents. in Monatshefte Fur Chemie. 2004;135(8):1009-1014.
doi:10.1007/s00706-004-0174-x .

Brborić, Jasmina, Vladimirov, Sote, Jovanović, Moma S., Dogović, N, "The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents" in Monatshefte Fur Chemie, 135, no. 8 (2004):1009-1014,
https://doi.org/10.1007/s00706-004-0174-x . .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Popovic, G
AU  - Kapetanovic, V
AU  - Orlić, Milan P.
AU  - Vladimirov, Sote
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2811
AB  - In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
VL  - 35
IS  - 5
SP  - 1257
EP  - 1261
DO  - 10.1016/j.jpba.2004.03.009
ER  - 

@article{
author = "Jovanović, Moma S. and Popovic, G and Kapetanovic, V and Orlić, Milan P. and Vladimirov, Sote",
year = "2004",
abstract = "In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. (C) 2004 Elsevier B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid",
volume = "35",
number = "5",
pages = "1257-1261",
doi = "10.1016/j.jpba.2004.03.009"
}

Jovanović, M. S., Popovic, G., Kapetanovic, V., Orlić, M. P.,& Vladimirov, S.. (2004). Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis, 35(5), 1257-1261.
https://doi.org/10.1016/j.jpba.2004.03.009

Jovanović MS, Popovic G, Kapetanovic V, Orlić MP, Vladimirov S. Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis. 2004;35(5):1257-1261.
doi:10.1016/j.jpba.2004.03.009 .

Jovanović, Moma S., Popovic, G, Kapetanovic, V, Orlić, Milan P., Vladimirov, Sote, "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid" in Journal of Pharmaceutical and Biomedical Analysis, 35, no. 5 (2004):1257-1261,
https://doi.org/10.1016/j.jpba.2004.03.009 . .

TY  - JOUR
AU  - Nikolić, Nadežda S.
AU  - Veselinović, Dragan S.
AU  - Vladimirov, Sote
AU  - Karljiković-Rajić, Katarina
AU  - Lingeman, H
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2714
AB  - Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis, for reduction of intermediary reactant diiminebisoxime (DI) (4,8-diaza-3,6,6,9-tetramethylundecane-3,8-diene-2,10-dione bisoxime) concerned two reductants (NaBH4 and KBH4), two solvents (ethanol and 2-propanol), and three mole ratios of reactant/reductants (1:1, 1:1.5, and 1:2). The simultaneous analysis of diastereo-enantiomeric HM-PAO content, as well as the content of starting DI, in different reduction mixtures were pet-formed using chiral ligand-exchange chromatography (CLEC). The separation of the samples of investigated reduction mixtures, obtained in the second step of HM-PAO synthesis, has been accomplished by using an achiral sorbent (RP- 18) and a chiral mobile phase (CMP) containing copper(II) complex with N,N-ditnethyl-L-phenylalanine (L-DM-PhA) as initial complex for CLEC. With 12 different reduction conditions, the obtained ratios of diastereoisomers d,l-HM-PAO: mesa-HM-PAO varied from 69.2:30.8 to 15.9:84.1, in comparison to the reduction in routine synthesis of HM-PAO which gives an equal mixture of diastereoisomers. The ternary mixed complexes formation recorded spectrophotometrically on addition of HM-PAO or DI to the mobile phase with binary complex Cu(L-DM-PhA)(2), due to the evidence of bathochromic shift of 46 nm for lambda(max) with significant difference in absorptivity contributes to separation mechanism. (C) 2003 Elsevier B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity
VL  - 34
IS  - 2
SP  - 285
EP  - 293
DO  - 10.1016/S0731-7085(03)00551-X
ER  - 

@article{
author = "Nikolić, Nadežda S. and Veselinović, Dragan S. and Vladimirov, Sote and Karljiković-Rajić, Katarina and Lingeman, H",
year = "2004",
abstract = "Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis, for reduction of intermediary reactant diiminebisoxime (DI) (4,8-diaza-3,6,6,9-tetramethylundecane-3,8-diene-2,10-dione bisoxime) concerned two reductants (NaBH4 and KBH4), two solvents (ethanol and 2-propanol), and three mole ratios of reactant/reductants (1:1, 1:1.5, and 1:2). The simultaneous analysis of diastereo-enantiomeric HM-PAO content, as well as the content of starting DI, in different reduction mixtures were pet-formed using chiral ligand-exchange chromatography (CLEC). The separation of the samples of investigated reduction mixtures, obtained in the second step of HM-PAO synthesis, has been accomplished by using an achiral sorbent (RP- 18) and a chiral mobile phase (CMP) containing copper(II) complex with N,N-ditnethyl-L-phenylalanine (L-DM-PhA) as initial complex for CLEC. With 12 different reduction conditions, the obtained ratios of diastereoisomers d,l-HM-PAO: mesa-HM-PAO varied from 69.2:30.8 to 15.9:84.1, in comparison to the reduction in routine synthesis of HM-PAO which gives an equal mixture of diastereoisomers. The ternary mixed complexes formation recorded spectrophotometrically on addition of HM-PAO or DI to the mobile phase with binary complex Cu(L-DM-PhA)(2), due to the evidence of bathochromic shift of 46 nm for lambda(max) with significant difference in absorptivity contributes to separation mechanism. (C) 2003 Elsevier B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity",
volume = "34",
number = "2",
pages = "285-293",
doi = "10.1016/S0731-7085(03)00551-X"
}

Nikolić, N. S., Veselinović, D. S., Vladimirov, S., Karljiković-Rajić, K.,& Lingeman, H.. (2004). Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity. in Journal of Pharmaceutical and Biomedical Analysis, 34(2), 285-293.
https://doi.org/10.1016/S0731-7085(03)00551-X

Nikolić NS, Veselinović DS, Vladimirov S, Karljiković-Rajić K, Lingeman H. Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity. in Journal of Pharmaceutical and Biomedical Analysis. 2004;34(2):285-293.
doi:10.1016/S0731-7085(03)00551-X .

Nikolić, Nadežda S., Veselinović, Dragan S., Vladimirov, Sote, Karljiković-Rajić, Katarina, Lingeman, H, "Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity" in Journal of Pharmaceutical and Biomedical Analysis, 34, no. 2 (2004):285-293,
https://doi.org/10.1016/S0731-7085(03)00551-X . .

TY  - JOUR
AU  - Marinković, Valentina D.
AU  - Agbaba, Danica
AU  - Karjikovic-Rajic, K
AU  - Vladimirov, Sote
AU  - Nedeljković, Jovan
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6377
AB  - The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Photochemical degradation of solid-state nisoldipine monitored by HPLC
VL  - 32
IS  - 4-5
SP  - 929
EP  - 935
DO  - 10.1016/S0731-7085(03)00194-8
ER  - 

@article{
author = "Marinković, Valentina D. and Agbaba, Danica and Karjikovic-Rajic, K and Vladimirov, Sote and Nedeljković, Jovan",
year = "2003",
abstract = "The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules). (C) 2003 Elsevier Science B.V. All rights reserved.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Photochemical degradation of solid-state nisoldipine monitored by HPLC",
volume = "32",
number = "4-5",
pages = "929-935",
doi = "10.1016/S0731-7085(03)00194-8"
}

Marinković, V. D., Agbaba, D., Karjikovic-Rajic, K., Vladimirov, S.,& Nedeljković, J.. (2003). Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 929-935.
https://doi.org/10.1016/S0731-7085(03)00194-8

Marinković VD, Agbaba D, Karjikovic-Rajic K, Vladimirov S, Nedeljković J. Photochemical degradation of solid-state nisoldipine monitored by HPLC. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(4-5):929-935.
doi:10.1016/S0731-7085(03)00194-8 .

Marinković, Valentina D., Agbaba, Danica, Karjikovic-Rajic, K, Vladimirov, Sote, Nedeljković, Jovan, "Photochemical degradation of solid-state nisoldipine monitored by HPLC" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 4-5 (2003):929-935,
https://doi.org/10.1016/S0731-7085(03)00194-8 . .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Suturkova, L
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2380
AB  - The partition coefficient (log P) for n-octanol/water system was calculated applying PACO program for various theoretically possible mono and dihalogenated IDA derivatives. Some of the synthesized ligands (SOLCOIODIDA, IODIDA and DIIODIDA) were labeled with the technetium-99m. The biodistribution and influence of bilirubin on their biokinetics were investigated in rats. The correlation between partition coefficients of ligands increase (log P) and better hepatobiliary properties of Tc-99m-IDA derivatives was determined. The values of log P increase from 1.16 for SOLCOIODIDA, 3.11 for IODIDA to 3.47 for DIIODIDA. In correlation with these results, biliary excretion decreased for 59% for Tc-99m-SOLCOIODIDA and 11% for Tc-99m-IODIDA and Tc-99m-DIIODIDA under hyperbilirubinemia (3.5 min after injection) and 45%, 11% and 0.38% respectively (15 min after injection). The highest biliary excretion had Tc-99m-DIIODIDA (55.4% for 3.5 min). Considering the correlation between hepatobiliary properties and log P, the evaluation of biological properties for various trifluoromethyl mono and dihalogenated IDA derivatives was performed on the basis of the calculated log P in order to synthetize a new radiopharmaceutical for hepatobiliary scintigraphy.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives
VL  - 245
IS  - 3
SP  - 555
EP  - 560
DO  - 10.1023/A:1006709310527
ER  - 

@article{
author = "Jovanović, Moma S. and Brborić, Jasmina and Vladimirov, Sote and Suturkova, L",
year = "2000",
abstract = "The partition coefficient (log P) for n-octanol/water system was calculated applying PACO program for various theoretically possible mono and dihalogenated IDA derivatives. Some of the synthesized ligands (SOLCOIODIDA, IODIDA and DIIODIDA) were labeled with the technetium-99m. The biodistribution and influence of bilirubin on their biokinetics were investigated in rats. The correlation between partition coefficients of ligands increase (log P) and better hepatobiliary properties of Tc-99m-IDA derivatives was determined. The values of log P increase from 1.16 for SOLCOIODIDA, 3.11 for IODIDA to 3.47 for DIIODIDA. In correlation with these results, biliary excretion decreased for 59% for Tc-99m-SOLCOIODIDA and 11% for Tc-99m-IODIDA and Tc-99m-DIIODIDA under hyperbilirubinemia (3.5 min after injection) and 45%, 11% and 0.38% respectively (15 min after injection). The highest biliary excretion had Tc-99m-DIIODIDA (55.4% for 3.5 min). Considering the correlation between hepatobiliary properties and log P, the evaluation of biological properties for various trifluoromethyl mono and dihalogenated IDA derivatives was performed on the basis of the calculated log P in order to synthetize a new radiopharmaceutical for hepatobiliary scintigraphy.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives",
volume = "245",
number = "3",
pages = "555-560",
doi = "10.1023/A:1006709310527"
}

Jovanović, M. S., Brborić, J., Vladimirov, S.,& Suturkova, L.. (2000). Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry, 245(3), 555-560.
https://doi.org/10.1023/A:1006709310527

Jovanović MS, Brborić J, Vladimirov S, Suturkova L. Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry. 2000;245(3):555-560.
doi:10.1023/A:1006709310527 .

Jovanović, Moma S., Brborić, Jasmina, Vladimirov, Sote, Suturkova, L, "Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives" in Journal of Radioanalytical and Nuclear Chemistry, 245, no. 3 (2000):555-560,
https://doi.org/10.1023/A:1006709310527 . .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Zmbova, B
AU  - Vuksanovic, LJ
AU  - Zivanov-Stakic, D
AU  - Obradović, V
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2246
AB  - A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
VL  - 240
IS  - 1
SP  - 321
EP  - 324
DO  - 10.1007/BF02349171
ER  - 

@article{
author = "Jovanović, Moma S. and Brborić, Jasmina and Vladimirov, Sote and Zmbova, B and Vuksanovic, LJ and Zivanov-Stakic, D and Obradović, V",
year = "1999",
abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging",
volume = "240",
number = "1",
pages = "321-324",
doi = "10.1007/BF02349171"
}

Jovanović, M. S., Brborić, J., Vladimirov, S., Zmbova, B., Vuksanovic, L., Zivanov-Stakic, D.,& Obradović, V.. (1999). New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry, 240(1), 321-324.
https://doi.org/10.1007/BF02349171

Jovanović MS, Brborić J, Vladimirov S, Zmbova B, Vuksanovic L, Zivanov-Stakic D, Obradović V. New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry. 1999;240(1):321-324.
doi:10.1007/BF02349171 .

Jovanović, Moma S., Brborić, Jasmina, Vladimirov, Sote, Zmbova, B, Vuksanovic, LJ, Zivanov-Stakic, D, Obradović, V, "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging" in Journal of Radioanalytical and Nuclear Chemistry, 240, no. 1 (1999):321-324,
https://doi.org/10.1007/BF02349171 . .

TY  - JOUR
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
AU  - Agbaba, Danica
AU  - Jovanovic, M
AU  - Živanov-Stakić, Dobrila
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7217
AB  - The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6)-3.19 x 10(-5) mol l(-1) (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 mu g ml(-1) (molar absorptivity found was 1.97 x 10(4) l mol(-1) cm(-1)). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10).
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine
VL  - 14
IS  - 8-10
SP  - 947
EP  - 950
DO  - 10.1016/0731-7085(95)01681-3
ER  - 

@article{
author = "Vladimirov, Sote and Čudina, Olivera and Agbaba, Danica and Jovanovic, M and Živanov-Stakić, Dobrila",
year = "1996",
abstract = "The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6)-3.19 x 10(-5) mol l(-1) (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 mu g ml(-1) (molar absorptivity found was 1.97 x 10(4) l mol(-1) cm(-1)). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10).",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine",
volume = "14",
number = "8-10",
pages = "947-950",
doi = "10.1016/0731-7085(95)01681-3"
}

Vladimirov, S., Čudina, O., Agbaba, D., Jovanovic, M.,& Živanov-Stakić, D.. (1996). Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine. in Journal of Pharmaceutical and Biomedical Analysis, 14(8-10), 947-950.
https://doi.org/10.1016/0731-7085(95)01681-3

Vladimirov S, Čudina O, Agbaba D, Jovanovic M, Živanov-Stakić D. Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine. in Journal of Pharmaceutical and Biomedical Analysis. 1996;14(8-10):947-950.
doi:10.1016/0731-7085(95)01681-3 .

Vladimirov, Sote, Čudina, Olivera, Agbaba, Danica, Jovanovic, M, Živanov-Stakić, Dobrila, "Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine" in Journal of Pharmaceutical and Biomedical Analysis, 14, no. 8-10 (1996):947-950,
https://doi.org/10.1016/0731-7085(95)01681-3 . .

TY  - JOUR
AU  - Jovanović, Moma S.
AU  - Vuksanovic, L
AU  - Brborić, Jasmina
AU  - Vladimirov, Sote
AU  - Živanov-Stakić, Dobrila
PY  - 1996
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2027
T2  - Jugoslovenska Medicinska Biohemija
T1  - Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA
VL  - 15
IS  - 4
SP  - 266
EP  - 266
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2027
ER  - 

@article{
author = "Jovanović, Moma S. and Vuksanovic, L and Brborić, Jasmina and Vladimirov, Sote and Živanov-Stakić, Dobrila",
year = "1996",
journal = "Jugoslovenska Medicinska Biohemija",
title = "Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA",
volume = "15",
number = "4",
pages = "266-266",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2027"
}

Jovanović, M. S., Vuksanovic, L., Brborić, J., Vladimirov, S.,& Živanov-Stakić, D.. (1996). Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA. in Jugoslovenska Medicinska Biohemija, 15(4), 266-266.
https://hdl.handle.net/21.15107/rcub_vinar_2027

Jovanović MS, Vuksanovic L, Brborić J, Vladimirov S, Živanov-Stakić D. Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA. in Jugoslovenska Medicinska Biohemija. 1996;15(4):266-266.
https://hdl.handle.net/21.15107/rcub_vinar_2027 .

Jovanović, Moma S., Vuksanovic, L, Brborić, Jasmina, Vladimirov, Sote, Živanov-Stakić, Dobrila, "Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA" in Jugoslovenska Medicinska Biohemija, 15, no. 4 (1996):266-266,
https://hdl.handle.net/21.15107/rcub_vinar_2027 .