TY  - CONF
AU  - Đorđević, Miloš
AU  - Chatzipapas, Konstantinos
AU  - Hoang Tran, Ngoc
AU  - Sakata, Dousatsu
AU  - Petrović, Ivan
AU  - Ristić-Fira, Aleksandra
AU  - Zein, Sara
AU  - Brown, Jeremy M.C.
AU  - Kyriakou, Ioanna
AU  - Emfietzoglou, Dimitris
AU  - Guatelli, Susanna
AU  - Incerti, Sebastien
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12658
AB  - The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-defined human cell geometries and it can be used to calculate the early direct and non-direct DNA damage such as single (SSB) and double strand breaks (DSB) as well as DNA fragment distribution. The application is user friendly and can be used following simple macro commands. The results of the Monte Carlo simulation are compared to experimental data of DSB yields, as well as with previously published simulation data.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA
SP  - 144
EP  - 147
DO  - 10.46793/ICCBI23.144D
ER  - 

@conference{
author = "Đorđević, Miloš and Chatzipapas, Konstantinos and Hoang Tran, Ngoc and Sakata, Dousatsu and Petrović, Ivan and Ristić-Fira, Aleksandra and Zein, Sara and Brown, Jeremy M.C. and Kyriakou, Ioanna and Emfietzoglou, Dimitris and Guatelli, Susanna and Incerti, Sebastien",
year = "2023",
abstract = "The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-defined human cell geometries and it can be used to calculate the early direct and non-direct DNA damage such as single (SSB) and double strand breaks (DSB) as well as DNA fragment distribution. The application is user friendly and can be used following simple macro commands. The results of the Monte Carlo simulation are compared to experimental data of DSB yields, as well as with previously published simulation data.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA",
pages = "144-147",
doi = "10.46793/ICCBI23.144D"
}

Đorđević, M., Chatzipapas, K., Hoang Tran, N., Sakata, D., Petrović, I., Ristić-Fira, A., Zein, S., Brown, J. M.C., Kyriakou, I., Emfietzoglou, D., Guatelli, S.,& Incerti, S.. (2023). Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 144-147.
https://doi.org/10.46793/ICCBI23.144D

Đorđević M, Chatzipapas K, Hoang Tran N, Sakata D, Petrović I, Ristić-Fira A, Zein S, Brown JM, Kyriakou I, Emfietzoglou D, Guatelli S, Incerti S. Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:144-147.
doi:10.46793/ICCBI23.144D .

Đorđević, Miloš, Chatzipapas, Konstantinos, Hoang Tran, Ngoc, Sakata, Dousatsu, Petrović, Ivan, Ristić-Fira, Aleksandra, Zein, Sara, Brown, Jeremy M.C., Kyriakou, Ioanna, Emfietzoglou, Dimitris, Guatelli, Susanna, Incerti, Sebastien, "Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):144-147,
https://doi.org/10.46793/ICCBI23.144D . .