Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA
Аутори
Đorđević, Miloš![](/themes/MirageVinar/images/orcid.png)
Chatzipapas, Konstantinos
Hoang Tran, Ngoc
Sakata, Dousatsu
Petrović, Ivan
![](/themes/MirageVinar/images/orcid.png)
Ristić-Fira, Aleksandra
![](/themes/MirageVinar/images/orcid.png)
Zein, Sara
Brown, Jeremy M.C.
Kyriakou, Ioanna
![](/themes/MirageVinar/images/orcid.png)
Emfietzoglou, Dimitris
Guatelli, Susanna
Incerti, Sebastien
![](/themes/MirageVinar/images/orcid.png)
Конференцијски прилог (Објављена верзија)
![](/themes/MirageVinar//images/creativecommons/arr.png)
Метаподаци
Приказ свих података о документуАпстракт
The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-defined human cell geometries and it can be used to calculate the early direct and non-direct DNA damage such as single (SSB) and double strand breaks (DSB) as well as DNA fragment distribution. The application is user friendly and can be used following simple macro commands. The results of the Monte Carlo simulation are compared to experimental data of DSB yields, as well as with previously publi...shed simulation data.
Кључне речи:
Geant4-DNA / Monte Carlo simulation / cancer / protons / helium ionsИзвор:
ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings, 2023, 144-147Издавач:
- Kragujevac : Institute for Information Technologies, University of Kragujevac
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- European Space Agency for its support to Geant4-DNA through the “BioRad3” project [contract 4000132935/21/NL/CRS, 2021- 2023]
- Hubert Curien Pavle Savic (PHC) "Monte Carlo simulation of irradiation with hadron beams" [grant number 337-00-93/2023-05/18]
Напомена:
- ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics, September 28-29, 2023; Kragujevac
Колекције
Институција/група
VinčaTY - CONF AU - Đorđević, Miloš AU - Chatzipapas, Konstantinos AU - Hoang Tran, Ngoc AU - Sakata, Dousatsu AU - Petrović, Ivan AU - Ristić-Fira, Aleksandra AU - Zein, Sara AU - Brown, Jeremy M.C. AU - Kyriakou, Ioanna AU - Emfietzoglou, Dimitris AU - Guatelli, Susanna AU - Incerti, Sebastien PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12658 AB - The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-defined human cell geometries and it can be used to calculate the early direct and non-direct DNA damage such as single (SSB) and double strand breaks (DSB) as well as DNA fragment distribution. The application is user friendly and can be used following simple macro commands. The results of the Monte Carlo simulation are compared to experimental data of DSB yields, as well as with previously published simulation data. PB - Kragujevac : Institute for Information Technologies, University of Kragujevac C3 - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings T1 - Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA SP - 144 EP - 147 DO - 10.46793/ICCBI23.144D ER -
@conference{ author = "Đorđević, Miloš and Chatzipapas, Konstantinos and Hoang Tran, Ngoc and Sakata, Dousatsu and Petrović, Ivan and Ristić-Fira, Aleksandra and Zein, Sara and Brown, Jeremy M.C. and Kyriakou, Ioanna and Emfietzoglou, Dimitris and Guatelli, Susanna and Incerti, Sebastien", year = "2023", abstract = "The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-defined human cell geometries and it can be used to calculate the early direct and non-direct DNA damage such as single (SSB) and double strand breaks (DSB) as well as DNA fragment distribution. The application is user friendly and can be used following simple macro commands. The results of the Monte Carlo simulation are compared to experimental data of DSB yields, as well as with previously published simulation data.", publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac", journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings", title = "Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA", pages = "144-147", doi = "10.46793/ICCBI23.144D" }
Đorđević, M., Chatzipapas, K., Hoang Tran, N., Sakata, D., Petrović, I., Ristić-Fira, A., Zein, S., Brown, J. M.C., Kyriakou, I., Emfietzoglou, D., Guatelli, S.,& Incerti, S.. (2023). Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings Kragujevac : Institute for Information Technologies, University of Kragujevac., 144-147. https://doi.org/10.46793/ICCBI23.144D
Đorđević M, Chatzipapas K, Hoang Tran N, Sakata D, Petrović I, Ristić-Fira A, Zein S, Brown JM, Kyriakou I, Emfietzoglou D, Guatelli S, Incerti S. Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:144-147. doi:10.46793/ICCBI23.144D .
Đorđević, Miloš, Chatzipapas, Konstantinos, Hoang Tran, Ngoc, Sakata, Dousatsu, Petrović, Ivan, Ristić-Fira, Aleksandra, Zein, Sara, Brown, Jeremy M.C., Kyriakou, Ioanna, Emfietzoglou, Dimitris, Guatelli, Susanna, Incerti, Sebastien, "Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):144-147, https://doi.org/10.46793/ICCBI23.144D . .